A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3

Autor: Atri Ta, Rafael Ricci-Azevedo, Swathy O. Vasudevan, Skylar S. Wright, Puja Kumari, Morena S. Havira, Meera Surendran Nair, Vijay A. Rathinam, Sivapriya Kailasan Vanaja

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Abstract Type I interferons (IFNs) are consequential cytokines in antibacterial defense. Whether and how bacterial pathogens inhibit innate immune receptor-driven type I IFN expression remains mostly unknown. By screening a library of enterohemorrhag

Externí odkaz: https://doaj.org/article/9c025fac55404ea49734af73fd2b44f6

Impact of Nutrient Intake on Hydration Biomarkers Following Exercise and Rehydration Using a Clustering-Based Approach

Autor: Colleen X. Muñoz, Evan C. Johnson, Laura J. Kunces, Amy L. McKenzie, Michael Wininger, Cory L. Butts, Aaron Caldwell, Adam Seal, Brendon P. McDermott, Jakob Vingren, Abigail T. Colburn, Skylar S. Wright, Virgilio Lopez III, Lawrence E. Armstrong, Elaine C. Lee

Publikováno v: Nutrients, Vol 12, Iss 5, p 1276 (2020)

We investigated the impact of nutrient intake on hydration biomarkers in cyclists before and after a 161 km ride, including one hour after a 650 mL water bolus consumed post-ride. To control for multicollinearity, we chose a clustering-based, machine

Externí odkaz: https://doaj.org/article/6ab9d12db7c848e88e5360a6eac876ac

Mechanisms and Consequences of Noncanonical Inflammasome-Mediated Pyroptosis

Autor: Skylar S. Wright, Vijay A. K. Rathinam, Swathy O. Vasudevan

Publikováno v: J Mol Biol

The noncanonical inflammasome, comprising inflammatory caspases 4, 5, or 11, monitors the cytosol for bacterial lipopolysaccharide (LPS). Intracellular LPS-elicited autoproteolysis of these inflammatory caspases leads to the cleavage of the pore-form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818fd44d35acaaa0b1ba1ff928f7b530
https://doi.org/10.1016/j.jmb.2021.167245

Structural basis for GSDMB pore formation and its targeting by IpaH7.8.

Autor: Wang C; Department of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT, USA., Shivcharan S; Department of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT, USA., Tian T; Department of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT, USA., Wright S; Department of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT, USA., Ma D; Department of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT, USA., Chang J; Department of Biochemistry & Molecular Biotechnology and Cryo-Electron Microscopy Core Facility, University of Massachusetts Chan Medical School, Worcester, MA, USA., Li K; Cryo-Electron Microscopy Core, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Song K; Department of Biochemistry & Molecular Biotechnology and Cryo-Electron Microscopy Core Facility, University of Massachusetts Chan Medical School, Worcester, MA, USA., Xu C; Department of Biochemistry & Molecular Biotechnology and Cryo-Electron Microscopy Core Facility, University of Massachusetts Chan Medical School, Worcester, MA, USA., Rathinam VA; Department of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT, USA., Ruan J; Department of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT, USA. ruan@uchc.edu.

Publikováno v: Nature [Nature] 2023 Apr; Vol. 616 (7957), pp. 590-597. Date of Electronic Publication: 2023 Mar 29.