Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Skylar J. Ferrara"'
Autor:
Thomas S. Scanlan, Skylar J. Ferrara
Publikováno v:
Journal of Medicinal Chemistry. 63:9742-9751
The blood-brain barrier is a major impediment for targeted central nervous system (CNS) therapeutics, especially with carboxylic acid-containing drugs. Nuclear receptor modulators, which often feature carboxylic acid motifs for target engagement, hav
Autor:
Priya Chaudhary, Thomas S. Scanlan, Edvinas Pocius, Brooke A. Napier, Gail Marracci, Hannah Miller, Skylar J. Ferrara, Evan Calkins, Dennis Bourdette, Margaret J. DeBell, Ben Emery
Publikováno v:
Cell Chem Biol
bioRxiv
bioRxiv
Triggering receptor expressed on myeloid cells-2 (TREM2) is a cell surface receptor on macrophages and microglia that senses and responds to disease associated signals to regulate the phenotype of these innate immune cells. The TREM2 signaling pathwa
Publikováno v:
Endocrinology. 159:2733-2740
Thyromimetics represent a class of experimental drugs that can stimulate tissue-selective thyroid hormone action. As such, thyromimetics should have effects on the hypothalamic-pituitary-thyroid (HPT) axis, but details of this action and the subseque
Publikováno v:
Acta Crystallographica Section E, Vol 67, Iss 1, Pp m48-m49 (2011)
The structure of the title compound, [Ni(C6H16N2)2]Br2 or [Ni(Et2en)2]Br2 (Et2en is asymmetric N,N-diethylethylenediamine), containing an NiII atom (site symmetry overline{1}) in square-planar NiN4 coordination, is described and contrasted with relat
Externí odkaz:
https://doaj.org/article/607c418210d44fee857f7069cd50110a
Autor:
Tapasree Banerji, Skylar J. Ferrara, Hannah Sanford-Crane, Tania Banerji, Thomas S. Scanlan, J. Matthew Meinig, Dennis Bourdette
Publikováno v:
ACS Chemical Neuroscience. 8:2468-2476
The blood-brain barrier (BBB) can be a substantial impediment to achieving therapeutic levels of drugs in the CNS. Certain chemical functionality such as the carboxylic acid is a general liability for BBB permeability preventing significant CNS distr
Autor:
Priya Chaudhary, Lisa L. Kirkemo, Meredith D. Hartley, Edvinas Pocius, Dennis Bourdette, Mitra D. Shokat, Tapasree Banerji, Danielle Galipeau, Gail Marracci, Margaret J. DeBell, Ian J. Tagge, Thomas S. Scanlan, Evan Calkins, Shelby Van Leuven, J. Matthew Meinig, Skylar J. Ferrara, Tania Banerji, Hannah Miller, Ben Emery
Publikováno v:
JCI Insight. 4
Oligodendrocyte processes wrap axons to form neuroprotective myelin sheaths, and damage to myelin in disorders, such as multiple sclerosis (MS), leads to neurodegeneration and disability. There are currently no approved treatments for MS that stimula
Autor:
Hannah Sanford-Crane, Thomas S. Scanlan, Tania Banerji, Tapasree Banerji, J. Matthew Meinig, Dennis Bourdette, Skylar J. Ferrara
Publikováno v:
ACS medicinal chemistry letters. 10(1)
[Image: see text] Thyroid hormone (TH) action is of clinical interest in treating demyelinating diseases of the central nervous system (CNS). Two amide prodrugs of sobetirome, a potent thyroid hormone agonist, were previously shown to significantly i
Autor:
Joel T. Mague, Skylar J. Ferrara, Karry Wright LeBlanc, Bo Wang, James P. Donahue, Elaine Haas
Publikováno v:
Inorganic Chemistry. 55:9173-9177
The mononuclear Cu(I) complexes [LCu(I)(SSi(i)Pr3)] (L = 1,1,1-tris(diphenylphosphinomethyl)ethane (triphos), 1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene (IMes)) have been prepared by ligand displacement from [LCu(I)Cl] with (i)Pr3SiS(-). Both c
Publikováno v:
Methods in Molecular Biology ISBN: 9781493979011
Thyroid hormone is a principal regulator of essential processes in vertebrate physiology and homeostasis. Synthetic derivatives of thyroid hormone, known as thyromimetics, display desirable therapeutic properties. Thoroughly understanding how thyromi
Autor:
Tapasree Banerji, Andrew Placzek, J. Matthew Meinig, Tania Banerji, Hannah Sanford-Crane, Skylar J. Ferrara, Meredith D. Hartley, Peter McTigue, Thomas S. Scanlan, Dennis Bourdette
Current therapeutic options for treating demyelinating disorders such as multiple sclerosis (MS) do not stimulate myelin repair, thus creating a clinical need for therapeutic agents that address axonal remyelination. Thyroid hormone is known to play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a2b9f29fc4e09d9692962fdc0a84382
https://europepmc.org/articles/PMC5505648/
https://europepmc.org/articles/PMC5505648/