Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Skye R. Doering"'
Autor:
Katherine N. Schlasner, Mark D. Ericson, Skye R. Doering, Katie T. Freeman, Mary Weinrich, Carrie Haskell-Luevano
Publikováno v:
Molecules, Vol 24, Iss 8, p 1463 (2019)
The five melanocortin receptors (MC1R–MC5R) are involved in numerous biological pathways, including steroidogenesis, pigmentation, and food intake. In particular, MC3R and MC4R knockout mice suggest that the MC3R and MC4R regulate energy homeostasi
Externí odkaz:
https://doaj.org/article/91cade2340a84991869dc61cb9c8d78d
Autor:
Courtney M Larson, Radleigh Santos, Richard A. Houghten, Mark D. Ericson, Katie T. Freeman, Zoe M. Koerperich, Rachel H Cho, Haley M. Donow, Clemencia Pinilla, Skye R. Doering, Travis M. Lavoi, Carrie Haskell-Luevano, Marc A. Giulianotti
Publikováno v:
J Med Chem
The melanocortin-4 receptor (MC4R) plays an important role in appetite. Agonist ligands that stimulate the MC4R decrease appetite, while antagonist compounds increase food consumption. Herein, a functional mixture-based positional scan identified nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d799fa35400e843e7186e1fca268b270
https://doi.org/10.1021/acs.jmedchem.1c01417
https://doi.org/10.1021/acs.jmedchem.1c01417
Autor:
Phaedra Geer, Marc A. Giulianotti, Skye R. Doering, Travis M. Lavoi, Mark D. Ericson, Radleigh Santos, Katie T. Freeman, Carrie Haskell-Luevano, Richard A. Houghten, Jon R. Appel, Ginamarie Debevec, Clemencia Pinilla
Publikováno v:
J Med Chem
The central melanocortin-3 and melanocortin-4 receptors (MC3R, MC4R) are key regulators of body weight and energy homeostasis. Herein, the discovery and characterization of first-in-class small molecule melanocortin agonists with selectivity for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9eb1c484c45bcbe6d841d2afad5501
https://doi.org/10.1021/acs.jmedchem.0c02041
https://doi.org/10.1021/acs.jmedchem.0c02041
Autor:
Skye R. Doering, Richard A. Houghten, Radleigh G. Santos, Carrie Haskell-Luevano, Ginamarie Debevec, Katlyn A. Fleming, Mike D. Powers, Marc A. Giulianotti, Katie T. Freeman, Clemencia Pinilla
Publikováno v:
Journal of Medicinal Chemistry. 62:2738-2749
The centrally expressed melanocortin-3 and melanocortin-4 receptors (MC3R, MC4R) are established targets to treat diseases of positive and negative energy homeostasis. We previously reported (J. Med. Chem. 60:4342 2017) mixture-based positional scann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f57332d6b98a732dcbb488866b62025
https://doi.org/10.1021/acs.jmedchem.9b00053
https://doi.org/10.1021/acs.jmedchem.9b00053
Autor:
Mark D. Ericson, Katherine N. Schlasner, Cody J. Lensing, Skye R. Doering, Carrie Haskell-Luevano, Katlyn A. Fleming
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1863:2414-2435
The discovery of the endogenous melanocortin agonists in the 1950s have resulted in sixty years of melanocortin ligand research. Early efforts involved truncations or select modifications of the naturally occurring agonists leading to the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d42f9775ea1ecb7c80fb052a054758
https://doi.org/10.1016/j.bbadis.2017.03.020
https://doi.org/10.1016/j.bbadis.2017.03.020
Autor:
Mary Weinrich, Skye R. Doering, Carrie Haskell-Luevano, Katherine N. Schlasner, Mark D. Ericson, Katie T. Freeman
Publikováno v:
Molecules, Vol 24, Iss 8, p 1463 (2019)
Molecules
Volume 24
Issue 8
Molecules
Volume 24
Issue 8
The five melanocortin receptors (MC1R&ndash
MC5R) are involved in numerous biological pathways, including steroidogenesis, pigmentation, and food intake. In particular, MC3R and MC4R knockout mice suggest that the MC3R and MC4R regulate energy h
MC5R) are involved in numerous biological pathways, including steroidogenesis, pigmentation, and food intake. In particular, MC3R and MC4R knockout mice suggest that the MC3R and MC4R regulate energy h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43f37587226cfa8319bcb3f142a97b4
https://www.mdpi.com/1420-3049/24/8/1463
https://www.mdpi.com/1420-3049/24/8/1463
Autor:
Katherine N, Schlasner, Mark D, Ericson, Skye R, Doering, Katie T, Freeman, Mary, Weinrich, Carrie, Haskell-Luevano
Publikováno v:
Molecules
The five melanocortin receptors (MC1R–MC5R) are involved in numerous biological pathways, including steroidogenesis, pigmentation, and food intake. In particular, MC3R and MC4R knockout mice suggest that the MC3R and MC4R regulate energy homeostasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5114c61171e8c470adfad71cca32a1aa
https://pubmed.ncbi.nlm.nih.gov/31013889
https://pubmed.ncbi.nlm.nih.gov/31013889
Autor:
Skye R. Doering, Radleigh G. Santos, Erica M. Haslach, Robert C. Speth, Jon R. Appel, Sathya M. Schnell, Phaedra Geer, Ginamarie Debevec, Katie T. Freeman, Clemencia Pinilla, Carrie Haskell-Luevano, Marvin L. Dirain, Richard A. Houghten, Marc A. Giulianotti
The centrally expressed melanocortin-3 and -4 receptors (MC3R/MC4R) have been studied as possible targets for weight management therapies, with a preponderance of studies focusing on the MC4R. Herein, a novel tetrapeptide scaffold [Ac-Xaa1 -Arg-(pI)D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd53c4fbe65c709a37cb81ca858a506c
https://europepmc.org/articles/PMC5672800/
https://europepmc.org/articles/PMC5672800/
Publikováno v:
Peptides 2015, Proceedings of the 24th American Peptide Symposium.
The melanocortin system has been implicated in various physiological functions including pigmentation [1,2], sexual function [3], cardiovascular function [4], memory [5], and energy homeostasis [6-10]. The energy homeostasis functions have been attri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93169ef87f7047bc5ac3c049cea22d17
https://doi.org/10.17952/24aps.2015.162
https://doi.org/10.17952/24aps.2015.162
The melanocortin system regulates many important functions in the body. There are five melanocortin G protein-coupled receptor subtypes known to date. Herein, we report a structure-activity relationship (SAR) study of a tetrapeptide lead discovered t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0804bf8b1535cef487de33daceb7e523
https://europepmc.org/articles/PMC4329596/
https://europepmc.org/articles/PMC4329596/