Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes.

Autor: Guo JL; Denali Therapeutics Inc., South San Francisco, CA, USA. Electronic address: guojing84@hotmail.com., Braun D; Denali Therapeutics Inc., South San Francisco, CA, USA., Fitzgerald GA; Denali Therapeutics Inc., South San Francisco, CA, USA., Hsieh YT; Denali Therapeutics Inc., South San Francisco, CA, USA., Rougé L; Denali Therapeutics Inc., South San Francisco, CA, USA., Litvinchuk A; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Steffek M; Denali Therapeutics Inc., South San Francisco, CA, USA., Propson NE; Denali Therapeutics Inc., South San Francisco, CA, USA., Heffner CM; Denali Therapeutics Inc., South San Francisco, CA, USA., Discenza C; Denali Therapeutics Inc., South San Francisco, CA, USA., Han SJ; Denali Therapeutics Inc., South San Francisco, CA, USA., Rana A; Denali Therapeutics Inc., South San Francisco, CA, USA., Skuja LL; Denali Therapeutics Inc., South San Francisco, CA, USA., Lin BQ; Denali Therapeutics Inc., South San Francisco, CA, USA., Sun EW; Denali Therapeutics Inc., South San Francisco, CA, USA., Davis SS; Denali Therapeutics Inc., South San Francisco, CA, USA., Balasundar S; Denali Therapeutics Inc., South San Francisco, CA, USA., Becerra I; Denali Therapeutics Inc., South San Francisco, CA, USA., Dugas JC; Denali Therapeutics Inc., South San Francisco, CA, USA., Ha C; Denali Therapeutics Inc., South San Francisco, CA, USA., Hsiao-Nakamoto J; Denali Therapeutics Inc., South San Francisco, CA, USA., Huang F; Denali Therapeutics Inc., South San Francisco, CA, USA., Jain S; Denali Therapeutics Inc., South San Francisco, CA, USA., Kung JE; Denali Therapeutics Inc., South San Francisco, CA, USA., Liau NPD; Denali Therapeutics Inc., South San Francisco, CA, USA., Mahon CS; Denali Therapeutics Inc., South San Francisco, CA, USA., Nguyen HN; Denali Therapeutics Inc., South San Francisco, CA, USA., Nguyen N; Denali Therapeutics Inc., South San Francisco, CA, USA., Samaddar M; Denali Therapeutics Inc., South San Francisco, CA, USA., Shi Y; Denali Therapeutics Inc., South San Francisco, CA, USA., Tatarakis D; Denali Therapeutics Inc., South San Francisco, CA, USA., Tian Y; Denali Therapeutics Inc., South San Francisco, CA, USA., Zhu Y; Denali Therapeutics Inc., South San Francisco, CA, USA., Suh JH; Denali Therapeutics Inc., South San Francisco, CA, USA., Sandmann T; Denali Therapeutics Inc., South San Francisco, CA, USA., Calvert MEK; Denali Therapeutics Inc., South San Francisco, CA, USA., Arguello A; Denali Therapeutics Inc., South San Francisco, CA, USA., Kane LA; Denali Therapeutics Inc., South San Francisco, CA, USA., Lewcock JW; Denali Therapeutics Inc., South San Francisco, CA, USA., Holtzman DM; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Koth CM; Denali Therapeutics Inc., South San Francisco, CA, USA., Di Paolo G; Denali Therapeutics Inc., South San Francisco, CA, USA. Electronic address: dipaolo@dnli.com.

Publikováno v: Cell [Cell] 2024 Nov 11. Date of Electronic Publication: 2024 Nov 11.

Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.

Autor: Logan T; Denali Therapeutics, South San Francisco, CA, USA., Simon MJ; Denali Therapeutics, South San Francisco, CA, USA., Rana A; Denali Therapeutics, South San Francisco, CA, USA., Cherf GM; Denali Therapeutics, South San Francisco, CA, USA., Srivastava A; Denali Therapeutics, South San Francisco, CA, USA., Davis SS; Denali Therapeutics, South San Francisco, CA, USA., Low RLY; Denali Therapeutics, South San Francisco, CA, USA., Chiu CL; Denali Therapeutics, South San Francisco, CA, USA., Fang M; Denali Therapeutics, South San Francisco, CA, USA., Huang F; Denali Therapeutics, South San Francisco, CA, USA., Bhalla A; Denali Therapeutics, South San Francisco, CA, USA., Llapashtica C; Denali Therapeutics, South San Francisco, CA, USA., Prorok R; Denali Therapeutics, South San Francisco, CA, USA., Pizzo ME; Denali Therapeutics, South San Francisco, CA, USA., Calvert MEK; Denali Therapeutics, South San Francisco, CA, USA., Sun EW; Denali Therapeutics, South San Francisco, CA, USA., Hsiao-Nakamoto J; Denali Therapeutics, South San Francisco, CA, USA., Rajendra Y; Denali Therapeutics, South San Francisco, CA, USA., Lexa KW; Denali Therapeutics, South San Francisco, CA, USA., Srivastava DB; Denali Therapeutics, South San Francisco, CA, USA., van Lengerich B; Denali Therapeutics, South San Francisco, CA, USA., Wang J; Denali Therapeutics, South San Francisco, CA, USA., Robles-Colmenares Y; Denali Therapeutics, South San Francisco, CA, USA., Kim DJ; Denali Therapeutics, South San Francisco, CA, USA., Duque J; Denali Therapeutics, South San Francisco, CA, USA., Lenser M; Denali Therapeutics, South San Francisco, CA, USA., Earr TK; Denali Therapeutics, South San Francisco, CA, USA., Nguyen H; Denali Therapeutics, South San Francisco, CA, USA., Chau R; Denali Therapeutics, South San Francisco, CA, USA., Tsogtbaatar B; Denali Therapeutics, South San Francisco, CA, USA., Ravi R; Denali Therapeutics, South San Francisco, CA, USA., Skuja LL; Denali Therapeutics, South San Francisco, CA, USA., Solanoy H; Denali Therapeutics, South San Francisco, CA, USA., Rosen HJ; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; On behalf of the ALLFTD investigators., Boeve BF; On behalf of the ALLFTD investigators; Department of Neurology, College of Medicine, Mayo Clinic, Rochester, MN, USA., Boxer AL; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; On behalf of the ALLFTD investigators., Heuer HW; Memory and Aging Center, Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; On behalf of the ALLFTD investigators., Dennis MS; Denali Therapeutics, South San Francisco, CA, USA., Kariolis MS; Denali Therapeutics, South San Francisco, CA, USA., Monroe KM; Denali Therapeutics, South San Francisco, CA, USA., Przybyla L; Denali Therapeutics, South San Francisco, CA, USA., Sanchez PE; Denali Therapeutics, South San Francisco, CA, USA., Meisner R; Denali Therapeutics, South San Francisco, CA, USA., Diaz D; Denali Therapeutics, South San Francisco, CA, USA., Henne KR; Denali Therapeutics, South San Francisco, CA, USA., Watts RJ; Denali Therapeutics, South San Francisco, CA, USA., Henry AG; Denali Therapeutics, South San Francisco, CA, USA., Gunasekaran K; Denali Therapeutics, South San Francisco, CA, USA., Astarita G; Denali Therapeutics, South San Francisco, CA, USA; Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC, USA., Suh JH; Denali Therapeutics, South San Francisco, CA, USA., Lewcock JW; Denali Therapeutics, South San Francisco, CA, USA., DeVos SL; Denali Therapeutics, South San Francisco, CA, USA. Electronic address: devos@dnli.com., Di Paolo G; Denali Therapeutics, South San Francisco, CA, USA. Electronic address: dipaolo@dnli.com.

Publikováno v: Cell [Cell] 2021 Sep 02; Vol. 184 (18), pp. 4651-4668.e25. Date of Electronic Publication: 2021 Aug 26.

Gap Junctions and NCA Cation Channels Are Critical for Developmentally Timed Sleep and Arousal in Caenorhabditis elegans .

Autor: Huang H; Department of Neuroscience, Robert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, Rhode Island 02912., Hayden DJ; Department of Neuroscience, Robert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, Rhode Island 02912., Zhu CT; Department of Ecology and Evolution, Brown University, Providence, Rhode Island 02912., Bennett HL; Department of Neuroscience, Robert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, Rhode Island 02912.; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island 02912., Venkatachalam V; Department of Physics, Harvard University, Cambridge, Massachusetts 02138.; Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138., Skuja LL; Department of Neuroscience, Robert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, Rhode Island 02912., Hart AC; Department of Neuroscience, Robert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, Rhode Island 02912 anne_hart@brown.edu.

Publikováno v: Genetics [Genetics] 2018 Dec; Vol. 210 (4), pp. 1369-1381. Date of Electronic Publication: 2018 Oct 15.