Effect of crystal freezing and small-molecule binding on internal cavity size in a large protein: X-ray and docking studies of lipoxygenase at ambient and low temperature at 2.0 Å resolution.

Autor: Skrzypczak-Jankun, E.¹ eskrzypczak@meduohio.edu, Borbulevych, O. Y.², Zavodszky, M. I.³, Baranski, M. R.⁴, Padmanabhan, K.³, Petricek, V.⁵, Jankun, J.¹

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The influence of a homologous protein impurity on lysozyme crystal growth

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Recent Applications of In Silico Approaches for Studying Receptor Mutations Associated with Human Pathologies.

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Mutagenesis, Hydrogen-Deuterium Exchange, and Molecular Docking Investigations Establish the Dimeric Interface of Human Platelet-Type 12-Lipoxygenase.

Autor: Tsai WC; Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, California 95064, United States., Aleem AM; Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, California 95064, United States., Whittington C; Department of Chemistry, East Carolina University, Greenville, North Carolina 27858, United States., Cortopassi WA; Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, San Francisco, California 94143, United States., Kalyanaraman C; Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, San Francisco, California 94143, United States., Baroz A; Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, California 95064, United States., Iavarone AT; QB3/Chemistry Mass Spectrometry Facility, University of California, Berkeley, Berkeley, California 94720, United States., Skrzypczak-Jankun E; Department of Urology, University of Toledo, Health Science Campus, Toledo, Ohio 43614, United States., Jacobson MP; Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, San Francisco, California 94143, United States., Offenbacher AR; Department of Chemistry, East Carolina University, Greenville, North Carolina 27858, United States., Holman T; Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, California 95064, United States.

Publikováno v: Biochemistry [Biochemistry] 2021 Mar 16; Vol. 60 (10), pp. 802-812. Date of Electronic Publication: 2021 Feb 26.

A novel lipophilic amiloride derivative efficiently kills chemoresistant breast cancer cells.

Autor: Hu, Michelle¹, Liu, Ruiwu¹, Castro, Noemi¹, Loza Sanchez, Liliana¹, Rueankham, Lapamas¹, Learn, Julie A.¹, Huang, Ruiqi¹, Lam, Kit S.¹, Carraway III, Kermit L.^1,2 klcarraway@ucdavis.edu

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