Targeted prostate cancer screening in men with mutations in BRCA1 and BRCA2 detects aggressive prostate cancer: preliminary analysis of the results of the IMPACT study

Autor: Mitra, Anita V, Bancroft, Elizabeth K, Barbachano, Yolanda, Page, Elizabeth C, Foster, C S, Jameson, C, Mitchell, G, Lindeman, G J, Stapleton, A, Suthers, G, Evans, D G, Cruger, D, Blanco, I, Mercer, C, Kirk, Jens, Maehle, L, Hodgson, S, Walker, L, Izatt, L, Douglas, F, Tucker, K, Dorkins, H, Clowes, V, Male, A, Donaldson, A, Brewer, C, Doherty, R, Bulman, B, Osther, P J, Salinas, M, Eccles, D, Axcrona, K, Jobson, I, Newcombe, B, Cybulski, C, Rubinstein, W S, Buys, S, Townshend, S, Friedman, E, Domchek, S, Ramon Y Cajal, T, Spigelman, A, Teo, S H, Skovsmose, Nicolai, Aaronson, N, Ardern-Jones, A, Bangma, C, Dearnaley, D, Eyfjord, J, Falconer, A

Publikováno v: BJU International, 107(1), 28-39. Wiley
Mitra, A V, Bancroft, E K, Barbachano, Y, Page, E C, Foster, C S, Jameson, C, Mitchell, G, Lindeman, G J, Stapleton, A, Suthers, G, Evans, D G, Cruger, D, Blanco, I, Mercer, C, Kirk, J, Maehle, L, Hodgson, S, Walker, L, Izatt, L, Douglas, F, Tucker, K, Dorkins, H, Clowes, V, Male, A, Donaldson, A, Brewer, C, Doherty, R, Bulman, B, Osther, P J, Salinas, M, Eccles, D, Axcrona, K, Jobson, I, Newcombe, B, Cybulski, C, Rubinstein, W S, Buys, S, Townshend, S, Friedman, E, Domchek, S, Ramon Y Cajal, T, Spigelman, A, Teo, S H, Skovsmose, N, Aaronson, N, Ardern-Jones, A, Bangma, C, Dearnaley, D, Eyfjord, J, Falconer, A & IMPACT Collaborators 2011, ' Targeted prostate cancer screening in men with mutations in BRCA1 and BRCA2 detects aggressive prostate cancer: preliminary analysis of the results of the IMPACT study ', B J U International
, vol. 107, no. 1, pp. 28-39 . https://doi.org/10.1111/j.1464-410X.2010.09648.x

What's known on the subject? and What does the study add? Scientists have found a number of genetic factors that increase prostate cancer risk, including heritable mutations in the genes BRCA1 and BRCA2. These mutations are not common but can have ma

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https://research.rug.nl/en/publications/5aa15235-cff9-48d2-9ec9-33486691f847