Enriched circulating and tumor-resident TGF-β+regulatory B cells in patients with melanoma promote FOXP3+Tregs

Autor: Robert J Harris, Zena Willsmore, Roman Laddach, Silvia Crescioli, Jitesh Chauhan, Anthony Cheung, Anna Black, Jenny L. C. Geh, Alastair D MacKenzie Ross, Ciaran Healy, Sophia Tsoka, James Spicer, Katie E Lacy, Sophia N Karagiannis

Publikováno v: Harris, R J, Willsmore, Z, Laddach, R, Crescioli, S, Chauhan, J, Cheung, A, Black, A, Geh, J L C, MacKenzie Ross, A D, Healy, C, Tsoka, S, Spicer, J, Lacy, K E & Karagiannis, S N 2022, ' Enriched circulating and tumor-resident TGF-β+ regulatory B cells in patients with melanoma promote FOXP3+ Tregs ', OncoImmunology, vol. 11, no. 1, 2104426, pp. 2104426 . https://doi.org/10.1080/2162402X.2022.2104426

B cells are emerging as key players of anti-tumor adaptive immune responses. We investigated regulatory and pro-inflammatory cytokine-expressing B cells in patients with melanoma by flow cytometric intracellular cytokine, CyTOF, transcriptomic, immun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae09673c24a2cdfed4c5599d2860ce6c
https://doi.org/10.1080/2162402x.2022.2104426

Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma

Autor: Niels Ødum, Sergei B. Koralov, Bas G.J. Surewaard, Thorbjørn Krejsgaard, Terkild B. Buus, Lise M. Lindahl, Shamaila Munir Ahmad, Claudia Nastasi, Anders Woetmann, Lise Mette Rahbek Gjerdrum, Rachael A. Clark, Andreas Willerslev-Olsen, Lars Iversen, Tengpeng Hu, Simon Fredholm, Jürgen C. Becker, Mads Hald Andersen, Carsten Geisler, Edda Blümel, Hanne Fogh, Charlotte M. Bonefeld, Maria Gluud

Publikováno v: Blümel, E, Munir Ahmad, S, Nastasi, C, Willerslev-Olsen, A, Gluud, M, Fredholm, S, Hu, T, Surewaard, B G J, Lindahl, L M, Fogh, H, Koralov, S B, Rahbek Gjerdrum, L M, Clark, R A, Iversen, L, Krejsgaard, T, Bonefeld, C M, Geisler, C, Becker, J C, Woetmann, A, Andersen, M H, Buus, T B & Ødum, N 2020, ' Staphylococcus aureus alpha-toxin inhibits CD8 + T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma ', OncoImmunology, vol. 9, no. 1, 1751561 . https://doi.org/10.1080/2162402X.2020.1751561
OncoImmunology, Vol 9, Iss 1 (2020)
Blümel, E, Munir Ahmad, S, Nastasi, C, Willerslev-Olsen, A, Gluud, M, Fredholm, S, Hu, T, Surewaard, B G J, Lindahl, L M, Fogh, H, Koralov, S B, Rahbek Gjerdrum, L M, Clark, R A, Iversen, L, Krejsgaard, T, Bonefeld, C M, Geisler, C, Becker, J C, Woetmann, A, Andersen, M H, Buus, T B & Ødum, N 2020, ' Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma ', OncoImmunology, vol. 9, no. 1, pp. 1751561 . https://doi.org/10.1080/2162402X.2020.1751561
Oncoimmunology

Staphylococcus aureus and its toxins have been linked to disease progression and mortality in advanced stages of cutaneous T-cell lymphoma (CTCL). CD8+ T cells play a crucial role in anti-cancer responses and high CD8+ T cell numbers in tumor lesions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c227141dd13596568b5954a415b5d59d
https://curis.ku.dk/ws/files/243011890/Staphylococcus_aureus_alpha_toxin_inhibits_CD8_T_cell_mediated_killing_of_cancer_cells_in_cutaneous_T_cell_lymphoma.pdf

CD29 identifies IFN-γ-producing human CD8+ T cells with an increased cytotoxic potential

Autor: Nicolet, Benoît P, Guislain, Aurélie, van Alphen, Floris P J, Gomez-Eerland, Raquel, Schumacher, Ton N M, van den Biggelaar, Maartje, Wolkers, Monika C, Afd Pharmaceutics, Pharmaceutics

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 117(12), 6686. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 117(12), 6686-6696. National Academy of Sciences

Cytotoxic CD8 + T cells can effectively kill target cells by producing cytokines, chemokines, and granzymes. Expression of these effector molecules is however highly divergent, and tools that identify and preselect CD8 + T cells with a cytotoxic expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73343329c79085b81488bf22e53a8251
https://hdl.handle.net/1874/411318

Quantitative TCR:pMHC Dissociation Rate Assessment by NTAmers Reveals Antimelanoma T Cell Repertoires Enriched for High Functional Competence

Autor: Daniel E. Speiser, Petra Baumgaertner, Mathilde Allard, Nathalie Rufer, Philippe O. Gannon, Sébastien Wieckowski, Michael Hebeisen

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 195(1)

Experimental models demonstrated that therapeutic induction of CD8 T cell responses may offer protection against tumors or infectious diseases providing that T cells have sufficiently high TCR/CD8:pMHC avidity for efficient Ag recognition and consequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92db76a4a495268de13c034695cd2b1e
https://pubmed.ncbi.nlm.nih.gov/26002978

Nano-particle vaccination combined with TLR-7 and -9 ligands triggers memory and effector CD8⁺ T-cell responses in melanoma patients

Autor: Goldinger, SM, Dummer, R, Baumgaertner, P, Mihic-Probst, D, Schwarz, K, Hammann-Haenni, A, Willers, J, Geldhof, C, Prior, JO, Kündig, TM, Michielin, O, Bachmann, MF, Speiser, DE

Publikováno v: European Journal of Immunology, vol. 42, no. 11, pp. 3049-3061
European Journal of Immunology

Optimal vaccine strategies must be identified for improving T-cell vaccination against infectious and malignant diseases. MelQbG10 is a virus-like nano-particle loaded with A-type CpG-oligonucleotides (CpG-ODN) and coupled to peptide(16-35) derived f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c2a961a5f3826a77e299439bc147982f
https://serval.unil.ch/notice/serval:BIB_FA34B494C8D3