Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Skin Absorption/physiology"'
Autor:
Camilla Smith
llergic Contact Dermatitis assesses the potential effects of xenobiotic metabolism and protein reactivity on toxicity. It reviews current knowledge of percutaneous absorption and skin metabolism and includes discussion of the xenobiotics themselves.
Autor:
Jens Ahm Sørensen, Lisbeth E. Knudsen, Jesper Baunsøe Nielsen, Per Axel Clausen, Heather M. Stapleton, Thomas F. Webster, Lars Schiøtt Sørensen, Marie Frederiksen, Flemming Nielsen, Katrin Vorkamp, Niels Martin Jensen
Publikováno v:
Frederiksen, M, Stapleton, H M, Vorkamp, K, Webster, T F, Jensen, N M, Sørensen, J A, Nielsen, F, Knudsen, L E, Sørensen, L S, Clausen, P A & Nielsen, J B 2018, ' Dermal uptake and percutaneous penetration of organophosphate esters in a human skin ex vivo model ', Chemosphere, vol. 197, pp. 185-192 . https://doi.org/10.1016/j.chemosphere.2018.01.032
Organophosphate esters (OPEs) are used as flame retardants, plasticizers, and as hydraulic fluids. They are present in indoor environments in high concentrations compared with other flame retardants, and human exposure is ubiquitous. In this study we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8a3f0d5727ab065c0f5c53038bd33d
https://pubmed.ncbi.nlm.nih.gov/29353672
https://pubmed.ncbi.nlm.nih.gov/29353672
Publikováno v:
Pharmaceutical Research, Vol. 23, No 8 (2006) pp. 1842-9
PURPOSE: To investigate the topical iontophoresis of valaciclovir (VCV) as a means to improve cutaneous aciclovir (ACV) delivery. METHODS: ACV and VCV electrotransport experiments were conducted using excised porcine skin in vitro. RESULTS: While the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d990fc39de498130add71ecb05722100
https://doi.org/10.1007/s11095-006-9017-2
https://doi.org/10.1007/s11095-006-9017-2
Publikováno v:
Pharmaceutical Research, Vol. 23, No 8 (2006) pp. 1850-6
OBJECTIVE: The objective was to investigate pig ear skin as a surrogate for human skin in the assessment of topical drug bioavailability by sequential tape-stripping of the stratum corneum (SC). The potential benefits of ex vivo investigations are ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b6cbef5029e0ef07cd4bea3c6c5559
https://doi.org/10.1007/s11095-006-9011-8
https://doi.org/10.1007/s11095-006-9011-8
Publikováno v:
Advanced Drug Delivery Reviews, Vol. 56, No 5 (2004) pp. 619-58
The composition and architecture of the stratum corneum render it a formidable barrier to the topical and transdermal administration of therapeutic agents. The physicochemical constraints severely limit the number of molecules that can be considered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5402033ac29df5c55059d7aa6e0878
https://doi.org/10.1016/j.addr.2003.10.026
https://doi.org/10.1016/j.addr.2003.10.026
Publikováno v:
Pharmaceutical Research, Vol. 21, No 1 (2004) pp. 83-92
PURPOSE: Development of reliable mathematical models to predict skin permeability remains a challenging objective. This article examines some of the existing algorithms and critically evaluates their statistical relevance. METHODS: Complete statistic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21cad7f8bb69e5e9281f2740a6eb31d
https://doi.org/10.1023/b:pham.0000012155.27488.2b
https://doi.org/10.1023/b:pham.0000012155.27488.2b
Skin Permeability Enhancement by Low Frequency Sonophoresis: Lipid Extraction and Transport Pathways
Publikováno v:
Journal of Pharmaceutical Sciences, Vol. 92, No 6 (2003) pp. 1138-46
The objective of this study was to shed light on the mechanism(s) by which low-frequency ultrasound (20 KHz) enhances the permeability of the skin. The physical effects on the barrier and the transport pathway, in particular, were examined. The amoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9231b9fa5775ee3d6e322a2093fba402
https://doi.org/10.1002/jps.10370
https://doi.org/10.1002/jps.10370
Publikováno v:
Brewer, J, Bloksgaard, M, Kubiak, J, Sørensen, J A & Bagatolli, L A 2013, ' Spatially Resolved Two-Color Diffusion Measurements in Human Skin Applied to Transdermal Liposome Penetration ', Journal of Investigative Dermatology, vol. 133, no. 5, pp. 1260-1268 . https://doi.org/10.1038/jid.2012.461
A multiphoton excitation-based fluorescence fluctuation spectroscopy method, Raster image correlation spectroscopy (RICS), was used to measure the local diffusion coefficients of distinct model fluorescent substances in excised human skin. In combina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557db5cd0705a8656adc9fa6dd36f2a9
https://portal.findresearcher.sdu.dk/da/publications/38af2b14-ab6e-4176-bfbb-d68f042bdc83
https://portal.findresearcher.sdu.dk/da/publications/38af2b14-ab6e-4176-bfbb-d68f042bdc83
Publikováno v:
Journal of Pharmaceutical Sciences, Vol. 93, No 12 (2004) pp. 2936-40
The objective was to develop an in vitro model for the developing skin of the premature neonate. Barriers of different levels of efficiency were produced by differentially tape-stripping the stratum corneum (SC) from the skin of excised porcine ears,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6afeb9e3f3293c9d7ac0dcb02c6265f
https://pubmed.ncbi.nlm.nih.gov/15459948
https://pubmed.ncbi.nlm.nih.gov/15459948
Autor:
Richard H. Guy, M. Begoña Delgado-Charro, Russell O. Potts, Gustavo Merino, Yogeshvar N. Kalia
Publikováno v:
Journal of Controlled Release, Vol. 88, No 1 (2003) pp. 85-94
The aims of this work were: (i) to examine the role of ultrasound (US) frequency and intensity on the transport of glucose and mannitol across porcine skin in vitro, (ii) to quantify the energy delivered to the skin during application of low-frequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570a5803ae6e87766b62bf5445645910
https://archive-ouverte.unige.ch/unige:21948
https://archive-ouverte.unige.ch/unige:21948