Výsledky vyhledávání - "Skin/metabolism/pathology"

Regulation and function of interleukin-36 cytokines

Autor: Esen Yonca Bassoy, Cem Gabay, Jennifer E. Towne

Publikováno v: Immunological Reviews, Vol. 281, No 1 (2018) pp. 169-178

The interleukin (IL)-36 cytokines include 3 agonists, IL-36α, IL-36β, and IL-36γ that bind to a common receptor composed of IL-36R and IL-1RAcP to stimulate inflammatory responses. IL-36Ra is a natural antagonist that binds to IL-36R, but does not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7718282a0d38ca5ae22bbb4ab620dde5
https://pubmed.ncbi.nlm.nih.gov/29247994

Zobrazit plný text záznamu

The severity of imiquimod-induced mouse skin inflammation is independent of endogenous IL-38 expression

Autor: Jennifer Palomo, Dominique Talabot-Ayer, Sabina Troccaz, Emiliana Rodriguez, Gaby Palmer

Publikováno v: PLoS ONE
PLOS ONE, Vol. 13, No 3 (2018) P. e0194667
PLoS ONE, Vol 13, Iss 3, p e0194667 (2018)

The IL-1 cytokine family includes eleven members, among which Il-36α, β and γ, IL-36Ra and IL-38. The IL-36 cytokines are involved in the pathogenesis of psoriasis. IL-38 is also expressed in the skin and was previously proposed to act as an IL-36

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12228c49c5c98cf7651dff9cbfdddbbc
https://pubmed.ncbi.nlm.nih.gov/29554104

Zobrazit plný text záznamu

Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects

Publikováno v: American journal of human genetics 101 (2017): 552–563. doi:10.1016/j.ajhg.2017.08.017
info:cnr-pdr/source/autori:De Mori R.; Romani M.; D'Arrigo S.; Zaki M.S.; Lorefice E.; Tardivo S.; Biagini T.; Stanley V.; Musaev D.; Fluss J.; Micalizzi A.; Nuovo S.; Illi B.; Chiapparini L.; Di Marcotullio L.; Issa M.Y.; Anello D.; Casella A.; Ginevrino M.; Leggins A.S.; Roosing S.; Alfonsi R.; Rosati J.; Schot R.; Mancini G.M.S.; Bertini E.; Dobyns W.B.; Mazza T.; Gleeson J.G.; Valente E.M./titolo:Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects/doi:10.1016%2Fj.ajhg.2017.08.017/rivista:American journal of human genetics/anno:2017/pagina_da:552/pagina_a:563/intervallo_pagine:552–563/volume:101
American Journal of Human Genetics, 101(4), 552-563. Cell Press
American Journal of Human Genetics, 101, 552-563
American Journal of Human Genetics, Vol. 101, No 4 (2017) pp. 552-563
American Journal of Human Genetics, 101, 4, pp. 552-563

The Sonic Hedgehog (SHH) pathway is a key signaling pathway orchestrating embryonic development, mainly of the CNS and limbs. In vertebrates, SHH signaling is mediated by the primary cilium, and genetic defects affecting either SHH pathway members or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c781d643834c7c6beefae2cd0570ae

Zobrazit plný text záznamu

Hypoxic Preconditioning Increases Skin Oxygenation and Viability but Does Not Alter VEGF Expression or Vascular Density

Autor: Kai U Schlaudraff, Elena N. Tkatchouk, Navid Alizadeh, Michael S. Pepper, Denys Montandon, Igor V. Ehrenburg, Brigitte Pittet

Publikováno v: High Altitude Medicine and Biology, Vol. 9, No 1 (2008) pp. 76-88

Intermittent hypoxia is known to elicit adaptive changes that increase tissue oxygen delivery. We investigated the effects of intermittent hypoxic exposure (IHE) in normal skin (course study) and evaluated whether preoperative IHE-preconditioning all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a769b6604cc1dd79d610d308655f84
https://doi.org/10.1089/ham.2008.1006

Zobrazit plný text záznamu

In vivo investigations on anti-fibrotic potential of proteasome inhibition in lung and skin fibrosis

Autor: Jean-Michel Dayer, Carlo Chizzolini, Constance Barazzone Argiroffo, Sylvie Ferrari-Lacraz, Filippo Naso, Jean-Claude Pache, Souad Djaafar, Yves Donati, Laurence Goffin, Massimo Bongiovanni, Serena Fineschi

Publikováno v: American Journal of Respiratory Cell and Molecular Biology, Vol. 39, No 4 (2008) pp. 458-465

In systemic sclerosis (SSc), a disease characterized by fibrosis of the skin and internal organs, the occurrence of interstitial lung disease is responsible for high morbidity and mortality. We previously demonstrated that proteasome inhibitors (PI)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c612300a79f9f93de3827e8c98091f
https://archive-ouverte.unige.ch/unige:1088

Zobrazit plný text záznamu

Human epidermal Langerhans cells express the tight junction protein claudin-1 and are present in human genetic claudin-1 deficiency (NISCH syndrome)

Autor: Conrad Hauser, Simone C. Zimmerli, Smail Hadj-Rabia, Katrin Kerl, Daniel Hohl

Publikováno v: Experimental dermatology, Vol. 17, No 1 (2008) pp. 20-3

Claudin-1 (CLDN1) is a structural tight junction (TJ) protein and is expressed in differentiating keratinocytes and Langerhans cells in the epidermis. Our objective was to identify immunoreactive CLDN1 in human epidermal Langerhans cells and to exami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8adf7909595605def491c3cd9ab6b3f
https://archive-ouverte.unige.ch/unige:758

Zobrazit plný text záznamu

Notch1 functions as a tumor suppressor in mouse skin

Autor: J. Alain Kummer, Kenneth Raj, Chi-chung Hui, G. Paolo Dotto, Mascha van Noort, Michael Nicolas, Freddy Radtke, Hans Clevers, Anita Wolfer, Pleasantine Mill

Publikováno v: Nature Genetics, 33, 416-421. Nature Publishing Group

Notch proteins are important in binary cell-fate decisions and inhibiting differentiation in many developmental systems, and aberrant Notch signaling is associated with tumorigenesis. The role of Notch signaling in mammalian skin is less well charact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af76906f9bcc20e44ed7f03347f74d27
https://pubmed.ncbi.nlm.nih.gov/12590261

Zobrazit plný text záznamu

Th17 cells favor inflammatory responses while inhibiting type I collagen deposition by dermal fibroblasts: differential effects in healthy and systemic sclerosis fibroblasts

Autor: Marie-Elise Truchetet, Elisa Montanari, Pier Luigi Meroni, Elena Raschi, Nicolò Constantino Brembilla, Carlo Chizzolini

Publikováno v: Arthritis research & therapy
Arthritis Research & Therapy
Arthritis Research and Therapy, Vol. 15, No 5 (2013) P. R151

Introduction: T helper (Th)-17 cells are increased in systemic sclerosis (SSc). We therefore assessed whether Th17 cells could modulate the inflammatory and fibrotic responses in dermal fibroblasts from healthy donors (HD) and SSc individuals. Method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6d0af23871017baa3f674d7662bcdd
https://doi.org/10.1186/ar4334

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání