Implementation of preemptive DNA sequence–based pharmacogenomics testing across a large academic medical center: The Mayo-Baylor RIGHT 10K Study

Autor: Wang, Liewei, Scherer, Steven E., Bielinski, Suzette J., Muzny, Donna M., Jones, Leila A., Black, John Logan, III, Moyer, Ann M., Giri, Jyothsna, Sharp, Richard R., Matey, Eric T., Wright, Jessica A., Oyen, Lance J., Nicholson, Wayne T., Wiepert, Mathieu, Sullard, Terri, Curry, Timothy B., Rohrer Vitek, Carolyn R., McAllister, Tammy M., St. Sauver, Jennifer L., Caraballo, Pedro J., Lazaridis, Konstantinos N., Venner, Eric, Qin, Xiang, Hu, Jianhong, Kovar, Christie L., Korchina, Viktoriya, Walker, Kimberly, Doddapaneni, HarshaVardhan, Wu, Tsung-Jung, Raj, Ritika, Denson, Shawn, Liu, Wen, Chandanavelli, Gauthami, Zhang, Lan, Wang, Qiaoyan, Kalra, Divya, Karow, Mary Beth, Harris, Kimberley J., Sicotte, Hugues, Peterson, Sandra E., Barthel, Amy E., Moore, Brenda E., Skierka, Jennifer M., Kluge, Michelle L., Kotzer, Katrina E., Kloke, Karen, Vander Pol, Jessica M., Marker, Heather, Sutton, Joseph A., Kekic, Adrijana, Ebenhoh, Ashley, Bierle, Dennis M., Schuh, Michael J., Grilli, Christopher, Erickson, Sara, Umbreit, Audrey, Ward, Leah, Crosby, Sheena, Nelson, Eric A., Levey, Sharon, Elliott, Michelle, Peters, Steve G., Pereira, Naveen, Frye, Mark, Shamoun, Fadi, Goetz, Matthew P., Kullo, Iftikhar J., Wermers, Robert, Anderson, Jan A., Formea, Christine M., El Melik, Razan M., Zeuli, John D., Herges, Joseph R., Krieger, Carrie A., Hoel, Robert W., Taraba, Jodi L., St. Thomas, Scott R., Absah, Imad, Bernard, Matthew E., Fink, Stephanie R., Gossard, Andrea, Grubbs, Pamela L., Jacobson, Therese M., Takahashi, Paul, Zehe, Sharon C., Buckles, Susan, Bumgardner, Michelle, Gallagher, Colette, Fee-Schroeder, Kelliann, Nicholas, Nichole R., Powers, Melody L., Ragab, Ahmed K., Richardson, Darcy M., Stai, Anthony, Wilson, Jaymi, Pacyna, Joel E., Olson, Janet E., Sutton, Erica J., Beck, Annika T., Horrow, Caroline, Kalari, Krishna R., Larson, Nicholas B., Liu, Hongfang, Wang, Liwei, Lopes, Guilherme S., Borah, Bijan J., Freimuth, Robert R., Zhu, Ye, Jacobson, Debra J., Hathcock, Matthew A., Armasu, Sebastian M., McGree, Michaela E., Jiang, Ruoxiang, Koep, Tyler H., Ross, Jason L., Hilden, Matthew G., Bosse, Kathleen, Ramey, Bronwyn, Searcy, Isabelle, Boerwinkle, Eric, Gibbs, Richard A., Weinshilboum, Richard M.

Publikováno v: In Genetics in Medicine May 2022 24(5):1062-1072

Preemptive Genotyping for Personalized Medicine: Design of the Right Drug, Right Dose, Right Time—Using Genomic Data to Individualize Treatment Protocol

Autor: Bielinski, Suzette J., Olson, Janet E., Pathak, Jyotishman, Weinshilboum, Richard M., Wang, Liewei, Lyke, Kelly J., Ryu, Euijung, Targonski, Paul V., Van Norstrand, Michael D., Hathcock, Matthew A., Takahashi, Paul Y., McCormick, Jennifer B., Johnson, Kiley J., Maschke, Karen J., Rohrer Vitek, Carolyn R., Ellingson, Marissa S., Wieben, Eric D., Farrugia, Gianrico, Morrisette, Jody A., Kruckeberg, Keri J., Bruflat, Jamie K., Peterson, Lisa M., Blommel, Joseph H., Skierka, Jennifer M., Ferber, Matthew J., Black, John L., Baudhuin, Linnea M., Klee, Eric W., Ross, Jason L., Veldhuizen, Tamra L., Schultz, Cloann G., Caraballo, Pedro J., Freimuth, Robert R., Chute, Christopher G., Kullo, Iftikhar J.

Publikováno v: In Mayo Clinic Proceedings January 2014 89(1):25-33

UGT1A1 sequence variants and bilirubin levels in early postnatal life: a quantitative approach

Autor: Matern Dietrich, Karon Brad S, Weaver Amy, Skierka Jennifer, Hanchard Neil A, Cook Walter, O'Kane Dennis J

Publikováno v: BMC Medical Genetics, Vol 12, Iss 1, p 57 (2011)

Abstract Background Fundamental to definitively identifying neonates at risk of developing significant hyperbilirubinemia is a better understanding of the genetic factors associated with early bilirubin rise. Previous genetic studies have focused on

Externí odkaz: https://doaj.org/article/cd1527075ac74435b16327e14a5e9029

Preemptive Pharmacogenomic Testing for Precision Medicine: A Comprehensive Analysis of Five Actionable Pharmacogenomic Genes Using Next-Generation DNA Sequencing and a Customized CYP2D6 Genotyping Cascade

Autor: Ji, Yuan, Skierka, Jennifer M., Blommel, Joseph H., Moore, Brenda E., VanCuyk, Douglas L., Bruflat, Jamie K., Peterson, Lisa M., Veldhuizen, Tamra L., Fadra, Numrah, Peterson, Sandra E., Lagerstedt, Susan A., Train, Laura J., Baudhuin, Linnea M., Klee, Eric W., Ferber, Matthew J., Bielinski, Suzette J., Caraballo, Pedro J., Weinshilboum, Richard M., Black, John L.

Significant barriers, such as lack of professional guidelines, specialized training for interpretation of pharmacogenomics (PGx) data, and insufficient evidence to support clinical utility, prevent preemptive PGx testing from being widely clinically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cfb3a7c8bbf9e06d0a79dac3b389a0be
https://europepmc.org/articles/PMC4851731/

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