Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Skf 525 a"'
Autor:
Tae Won Jeon, Michael P. Holsapple, Tae Cheon Jeong, Hye Gwang Jeong, Eung-Seok Lee, Hyeun Wook Chang
Publikováno v:
Journal of toxicology and environmental health. Part A. 67(23-24)
Studies demonstrated that cocaine-induced immunosuppression is mediated by metabolites of cocaine. Although SKF 525-A inhibited cocaine N-demethylation in liver S9 fractions isolated from female B6C3F1 mice, our study showed that pretreatment of mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3d1ce348a5d5e5ccb5208788976580
https://pubmed.ncbi.nlm.nih.gov/15513895
https://pubmed.ncbi.nlm.nih.gov/15513895
Autor:
Michael R. Franklin
Publikováno v:
Xenobiotica. 4:143-150
1. During hepatic microsomal oxidative metabolism, N-substituted amphetamines form complexes with cytochrome P-450 which absorb maximally at 455 nm.2. The formation of these metabolite-cytochrome P-450 complexes is inhibited by hexobarbital and SKF 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f95fd1ed9b9e2751f3764e4b1105373
https://doi.org/10.3109/00498257409049354
https://doi.org/10.3109/00498257409049354
Publikováno v:
Chemical and Pharmaceutical Bulletin. 28:2154-2157
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a8f76f8aa93ac62e69ba263c6e27eed
https://doi.org/10.1248/cpb.28.2154
https://doi.org/10.1248/cpb.28.2154
Publikováno v:
Pharmacology. 16:181-192
Studies were undertaken to assess the ability of various in vitro and in vivo pentobarbital-metabolizing systems to reflect modifications in pentobarbital respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50eada2d6aefc529339471db1965ae84
https://doi.org/10.1159/000136765
https://doi.org/10.1159/000136765
Autor:
Frans M. Belpaire, Bogaert Mg
Publikováno v:
Xenobiotica. 5:431-438
1. The metabolism of papaverine was studied in vitro using the 9000 g fraction of rat liver. Apparent Km and Vmax values were 1.6 X 10-5 M and 34 nmol/g/min. Three monodemethylated metabolites were found by t.l.c. 2. Pre-treatment of rats with phenob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c4244e2c2b8cd4b25ff6513172a3ad
https://doi.org/10.3109/00498257509056113
https://doi.org/10.3109/00498257509056113
Autor:
H. Barry, R.D. Sofia
Publikováno v:
Pharmacology. 27:223-236
Δ9-Tetrahydrocannabinol (THC) markedly potentiated barbital Na sleeping time in mice and rats. The magnitude and duration of this effect were markedly enhanced when the animals were pretrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1adc294fd21e8a06a71312ec3e6c9b77
https://doi.org/10.1159/000137875
https://doi.org/10.1159/000137875
Publikováno v:
Chemico-Biological Interactions. 47:45-55
SKF 525-A induces several subpopulations of cytochrome P-450 which differ in their chromatographic properties and in their abilities to sequester themselves as metabolic-intermediate complexes. The two major subpopulations induced by SKF 525-A have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a308edf02bc11f1a0fb06df69e4b755
https://doi.org/10.1016/0009-2797(83)90146-1
https://doi.org/10.1016/0009-2797(83)90146-1
Autor:
Matti Laitinen, Jukka Marniemi
Publikováno v:
International Journal of Biochemistry. 6:345-352
1. 1. The reciprocal velocity plots of partially purified UDPglucuronosyltransferase of rat liver microsomes were concave suggesting negative co-operativity. The degree of curvature was not, however, as sharp as with plots obtained from native micros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba5905625e8c59feb2e9680be77da8f1
https://doi.org/10.1016/0020-711x(75)90085-3
https://doi.org/10.1016/0020-711x(75)90085-3
Autor:
Erik Dybing
Publikováno v:
Biochemical Pharmacology. 22:591-600
Chlorpromazine (CPZ) and SKF 525-A above 0.01 mM inhibit the incorporation of alanine into protein in cultures of a clonal strain of rat hepatoma cells. Fifty per cent inhibition was noted for both drugs at approximately 0.07 mM, and at CPZ 0.15 mM 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ded9978c54f523bb85afb5f74d3a124
https://doi.org/10.1016/0006-2952(73)90373-0
https://doi.org/10.1016/0006-2952(73)90373-0