Zobrazeno 1 - 10
of 425
pro vyhledávání: '"Skeletal disease"'
Autor:
Zebin Wu, Wenming Li, Kunlong Jiang, Zhixiang Lin, Chen Qian, Mingzhou Wu, Yu Xia, Ning Li, Hongtao Zhang, Haixiang Xiao, Jiaxiang Bai, Dechun Geng
Publikováno v:
MedComm, Vol 5, Iss 8, Pp n/a-n/a (2024)
Abstract As a highly dynamic tissue, bone is continuously rebuilt throughout life. Both bone formation by osteoblasts and bone resorption by osteoclasts constitute bone reconstruction homeostasis. The equilibrium of bone homeostasis is governed by ma
Externí odkaz:
https://doaj.org/article/483fcc0a12aa4d3aa9c567b8c2dec7db
Autor:
Xiaobo Yang, Shaodian Zhang, Jinwei Lu, Xiaoling Chen, Tian Zheng, Rongxin He, Chenyi Ye, Jianbin Xu
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Skeletal diseases impose a considerable burden on society. The clinical and tissue-engineering therapies applied to alleviate such diseases frequently result in complications and are inadequately effective. Research has shifted from conventional ther
Externí odkaz:
https://doaj.org/article/514827ac6591486e8872c64f4f8d489c
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Autoimmune diseases are affected by complex pathophysiology involving multiple cell types, cytokines, antibodies and mimicking factors. Different drugs are used to improve these autoimmune responses, including nonsteroidal anti-inflammatory drugs (NS
Externí odkaz:
https://doaj.org/article/41f619ba5c754156b781c0b51f683506
Akademický článek
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Autor:
Williams, Justin N.
Indiana University-Purdue University Indianapolis (IUPUI)
Type 2 diabetes mellitus (T2DM) is a growing problem globally and is associated with increased fracture risk and delayed bone healing. Novel approaches are needed in the treatment of T2DM
Type 2 diabetes mellitus (T2DM) is a growing problem globally and is associated with increased fracture risk and delayed bone healing. Novel approaches are needed in the treatment of T2DM
Externí odkaz:
https://hdl.handle.net/1805/29736
Autor:
Haydee M. Torres, Tania Rodezno-Antunes, Ashley VanCleave, Yuxia Cao, Dakota L. Callahan, Jennifer J. Westendorf, Jianning Tao
Publikováno v:
Journal of Advanced Veterinary and Animal Research, Vol 8, Iss 1, Pp 7-13 (2021)
Objective: Humpback (hpbk) mice harbor a pathogenic mutation in the Notch3 gene and can serve as a beneficial animal model for investigating human myopathy, kyphosis, and developmen¬tal disorders, including lateral meningocele syndrome. Detection of
Externí odkaz:
https://doaj.org/article/c23afc6446e84e90a65bb23b674141fb
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
BackgroundDespite the new next-generation sequencing (NGS) molecular approaches implemented the genetic testing in clinical diagnosis, copy number variation (CNV) detection from NGS data remains difficult mainly in the absence of bioinformatics perso
Externí odkaz:
https://doaj.org/article/a09ca03b26e24bba9508542aa1b6cce3
Akademický článek
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Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
X-Linked recessive chondrodysplasia punctata (CDPX1) is a rare skeletal dysplasia characterized by stippled epiphyses, brachytelephalangy, and nasomaxillary hypoplasia. CDPX1 is caused by function loss of arylsulfatase E (ARSE, also known as ARSL). P
Externí odkaz:
https://doaj.org/article/2dd11810938343ad8d9c0c1ef3e90819
Autor:
Huiqin Bian, Ting Zhu, Yuting Liang, Ruoxuan Hei, Xiaojing Zhang, Xiaochen Li, Jinnan Chen, Yaojuan Lu, Junxia Gu, Longwei Qiao, Qiping Zheng
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Hypertrophic chondrocytes and their specific marker, the type X collagen gene (Col10a1), are critical components of endochondral bone formation during skeletal development. We previously found that Runx2 is an indispensable mouse Col10a1 gene regulat
Externí odkaz:
https://doaj.org/article/b1b34507dc274e6b9ba0a52d5f27e508