Zobrazeno 1 - 10 of 34 pro vyhledávání: '"Skarphedinn Halldorsson"'
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Akademický článek
Argininosuccinate lyase is a metabolic vulnerability in breast development and cancer
Autor: Sigurdur Trausti Karvelsson, Qiong Wang, Bylgja Hilmarsdottir, Arnar Sigurdsson, Siver Andreas Moestue, Gunhild Mari Mælandsmo, Skarphedinn Halldorsson, Steinn Gudmundsson, Ottar Rolfsson
Publikováno v: npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract Epithelial-to-mesenchymal transition (EMT) is fundamental to both normal tissue development and cancer progression. We hypothesized that EMT plasticity defines a range of metabolic phenotypes and that individual breast epithelial metabolic p
Externí odkaz: https://doaj.org/article/cdfa07e4bd6d4ad0a6994536dab48cac
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2
Akademický článek
Azithromycin induces epidermal differentiation and multivesicular bodies in airway epithelia
Autor: Ari Jon Arason, Jon Petur Joelsson, Bryndis Valdimarsdottir, Snaevar Sigurdsson, Alexander Gudjonsson, Skarphedinn Halldorsson, Freyr Johannsson, Ottar Rolfsson, Fredrik Lehmann, Saevar Ingthorsson, Paulina Cherek, Gudmundur H. Gudmundsson, Fridrik R. Gardarsson, Clive P. Page, Olafur Baldursson, Thorarinn Gudjonsson, Jennifer A. Kricker
Publikováno v: Respiratory Research, Vol 20, Iss 1, Pp 1-19 (2019)
Abstract Background Azithromycin (Azm) is a macrolide recognized for its disease-modifying effects and reduction in exacerbation of chronic airway diseases. It is not clear whether the beneficial effects of Azm are due to its anti-microbial activity
Externí odkaz: https://doaj.org/article/c8da4be92fa246189c8660fe3fd024d1
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3
Akademický článek
EGFR Signal-Network Reconstruction Demonstrates Metabolic Crosstalk in EMT.
Autor: Kumari Sonal Choudhary, Neha Rohatgi, Skarphedinn Halldorsson, Eirikur Briem, Thorarinn Gudjonsson, Steinn Gudmundsson, Ottar Rolfsson
Publikováno v: PLoS Computational Biology, Vol 12, Iss 6, p e1004924 (2016)
Epithelial to mesenchymal transition (EMT) is an important event during development and cancer metastasis. There is limited understanding of the metabolic alterations that give rise to and take place during EMT. Dysregulation of signalling pathways t
Externí odkaz: https://doaj.org/article/3c9f0d064fa4467b90578c7e95b6d56c
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4
Akademický článek
deltaNp63 has a role in maintaining epithelial integrity in airway epithelium.
Autor: Ari Jon Arason, Hulda R Jonsdottir, Skarphedinn Halldorsson, Berglind Eva Benediktsdottir, Jon Thor Bergthorsson, Saevar Ingthorsson, Olafur Baldursson, Satrajit Sinha, Thorarinn Gudjonsson, Magnus K Magnusson
Publikováno v: PLoS ONE, Vol 9, Iss 2, p e88683 (2014)
The upper airways are lined with a pseudostratified bronchial epithelium that forms a barrier against unwanted substances in breathing air. The transcription factor p63, which is important for stratification of skin epithelium, has been shown to be e
Externí odkaz: https://doaj.org/article/7ee2d0d85e3c4f28814a8743b7be37bd
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10
Data from EMT-Derived Alterations in Glutamine Metabolism Sensitize Mesenchymal Breast Cells to mTOR Inhibition
Autor: Skarphedinn Halldorsson, Ottar Rolfsson, Siver Andreas Moestue, Gunhild Mari Mælandsmo, Freyr Johannsson, Qiong Wang, Maria Tunset Grinde, Kotryna Seip, Arnar Sigurdsson, Sigurdur Trausti Karvelsson
Epithelial-to-mesenchymal transition (EMT) is a fundamental developmental process with strong implications in cancer progression. Understanding the metabolic alterations associated with EMT may open new avenues of treatment and prevention. Here we us
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::624ac62b19021f444f428bd1f6717595
https://doi.org/10.1158/1541-7786.c.6544989.v1
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