A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target.

Autor: Freeman ZT; Department of Oncology and.; Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.; Unit for Laboratory Animal Medicine, Medical School.; Rogel Cancer Center, and., Nirschl TR; Department of Oncology and.; Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Hovelson DH; Department of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA., Johnston RJ; Bristol-Myers Squibb, Redwood City, California, USA., Engelhardt JJ; Bristol-Myers Squibb, Redwood City, California, USA., Selby MJ; Bristol-Myers Squibb, Redwood City, California, USA., Kochel CM; Department of Oncology and.; Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Lan RY; Bristol-Myers Squibb, Redwood City, California, USA., Zhai J; Department of Biostatistics, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA., Ghasemzadeh A; Department of Oncology and.; Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Gupta A; Department of Oncology and.; Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Skaist AM; Department of Oncology and.; Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Wheelan SJ; Department of Oncology and.; Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Jiang H; Rogel Cancer Center, and.; Department of Biostatistics, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA., Pearson AT; Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, Illinois, USA., Snyder LA; Oncology Discovery, Janssen R&D, Spring House, Pennsylvania, USA., Korman AJ; Bristol-Myers Squibb, Redwood City, California, USA., Tomlins SA; Rogel Cancer Center, and.; Department of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Michigan Center for Translational Pathology, Department of Pathology, and.; Department of Urology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA., Yegnasubramanian S; Department of Oncology and.; Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.; Brady Urological Institute, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Drake CG; Department of Oncology and.; Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.; Brady Urological Institute, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.; Division of Hematology and Oncology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2020 Mar 02; Vol. 130 (3), pp. 1405-1416.

Integrated Analysis of Whole-Genome ChIP-Seq and RNA-Seq Data of Primary Head and Neck Tumor Samples Associates HPV Integration Sites with Open Chromatin Marks.

Autor: Kelley DZ; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Flam EL; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Izumchenko E; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Danilova LV; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Laboratory of Systems Biology and Computational Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia., Wulf HA; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Guo T; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Singman DA; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Afsari B; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Skaist AM; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Considine M; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Welch JA; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Pathology, Johns Hopkins Medical School of Medicine, Baltimore, Maryland., Stavrovskaya E; Department of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia.; Institute for Information Transmission Problems, RAS, Moscow, Russia., Bishop JA; Department of Pathology, Johns Hopkins Medical School of Medicine, Baltimore, Maryland., Westra WH; Department of Pathology, Johns Hopkins Medical School of Medicine, Baltimore, Maryland., Khan Z; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Koch WM; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Sidransky D; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Wheelan SJ; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Califano JA; Head and Neck Cancer Center, Moores Cancer Center, University of California, San Diego, La Jolla, California.; Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California, San Diego, La Jolla, California., Favorov AV; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Laboratory of Systems Biology and Computational Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.; Laboratory of Bioinformatics, Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow, Russia., Fertig EJ; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Gaykalova DA; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland. dgaykal1@jhmi.edu.

Publikováno v: Cancer research [Cancer Res] 2017 Dec 01; Vol. 77 (23), pp. 6538-6550. Date of Electronic Publication: 2017 Sep 25.

NUP98-PHF23 fusion is recurrent in acute myeloid leukemia and shares gene expression signature of leukemic stem cells.

Autor: Ho H; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Skaist AM; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Pallavajjala A; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Yonescu R; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Batista D; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Wheelan SJ; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Ning Y; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address: yning5@jhmi.edu.

Publikováno v: Leukemia research [Leuk Res] 2016 Jun; Vol. 45, pp. 1-7. Date of Electronic Publication: 2016 Mar 30.