Pressure-compacted and spider silk-reinforced fibrin demonstrates sufficient biomechanical stability as cardiac patch in vitro

Autor: Florian Helms, Alexander Horke, Axel Haverich, Melanie Klingenberg, Dmitry Bobylev, Ulrike Böer, Skadi Lau, Thomas Hassel, Markus Mlinaric, Elena Petená, Mathias Wilhelmi

Publikováno v: Journal of biomaterials applications. 36(6)

Objective: The generation of bio-/hemocompatible cardiovascular patches with sufficient stability and regenerative potential remains an unmet goal. Thus, the aim of this study was the generation and in vitro biomechanical evaluation of a novel cardio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::273655a03dfe6eb76cabd8705136b5fb
https://pubmed.ncbi.nlm.nih.gov/34617818

Complete Myogenic Differentiation of Adipogenic Stem Cells Requires Both Biochemical and Mechanical Stimulation

Autor: Thomas Aper, Mathias Wilhelmi, Florian Helms, Ulrike Böer, Melanie Klingenberg, Axel Haverich, Skadi Lau

Publikováno v: Annals of Biomedical Engineering. 48:913-926

Vascular tissue engineering of the middle layer of natural arteries requires contractile smooth muscle cells (SMC) which can be differentiated from adipose-derived mesenchymal stem cells (ASC) by treatment with transforming growth factor-β, sphingos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048d041febce20099a198c2a19434172
https://doi.org/10.1007/s10439-019-02234-z

Establishment of an in vitro thrombogenicity test system with cyclic olefin copolymer substrate for endothelial layer formation

Autor: Anna Maier, Manfred Gossen, Skadi Lau, Axel T. Neffe, S. Braune, Yue Liu, Andreas Lendlein

Publikováno v: Lau, S.; Liu, Y.; Maier, A.; Braune, S.; Gossen, M.; Neffe, A.; Lendlein, A.: Establishment of an in vitro thrombogenicity test system with cyclic olefin copolymer substrate for endothelial layer formation. In: MRS Communications. Vol. 11 (2021) 5, 559-567. (DOI: /10.1557/s43579-021-00072-6)
Mrs Communications

Graphic abstract In vitro thrombogenicity test systems require co-cultivation of endothelial cells and platelets under blood flow-like conditions. Here, a commercially available perfusion system is explored using plasma-treated cyclic olefin copolyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ea87d1caef94c23a26789b2b79487b
https://publications.hzg.de/id/40313

Dehydration improves biomechanical strength of bioartificial vascular graft material and allows its long-term storage

Autor: Axel Haverich, Ulrike Böer, Skadi Lau, Andres Hilfiker, Nils Benecke, Thomas Aper, Mathias Wilhelmi

Publikováno v: Innovative Surgical Science, Vol 3, Iss 3, Pp 215-224 (2018)
Innovative Surgical Sciences

IntroductionWe have recently reported about a novel technique for the generation of bioartificial vascular grafts based on the use of a compacted fibrin matrix. In this study, we evaluated the effects of a dehydration process on the biomechanical pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89aaf1c74d069405e4f6a6e7335a0184
https://doaj.org/article/1fe393805ba948bca121a9345d770ce4

Venous and Arterial Endothelial Cells from Human Umbilical Cords: Potential Cell Sources for Cardiovascular Research

Autor: Skadi Lau, Andreas Lendlein, Friedrich Jung, Manfred Gossen

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 978, p 978 (2021)
Volume 22
Issue 2
Lau, S.; Gossen, M.; Lendlein, A.; Jung, F.: Venous and Arterial Endothelial Cells from Human Umbilical Cords: Potential Cell Sources for Cardiovascular Research . In: International Journal of Molecular Sciences. Vol. 22 (2021) 2, 978. (DOI: /10.3390/ijms22020978)

Although cardiovascular devices are mostly implanted in arteries or to replace arteries, in vitro studies on implant endothelialization are commonly performed with human umbilical cord-derived venous endothelial cells (HUVEC). In light of considerabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990b6ce3c2bbe851edaba3e2a05727f0
https://doi.org/10.3390/ijms22020978