Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Sjoerd Wanrooij"'
Autor:
Almaz A. Akhunzianov, Alfiya I. Nesterova, Sjoerd Wanrooij, Yulia V. Filina, Albert A. Rizvanov, Regina R. Miftakhova
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11540 (2023)
Antibiotics inhibit breast cancer stem cells (CSCs) by suppressing mitochondrial biogenesis. However, the effectiveness of antibiotics in clinical settings is inconsistent. This inconsistency raises the question of whether the tumor microenvironment,
Externí odkaz:
https://doaj.org/article/8aecf8cba67846c888b5108f85430ee2
Autor:
Kazutoshi Kasho, Lukas Krasauskas, Vytautas Smirnovas, Gorazd Stojkovič, Ludmilla A. Morozova-Roche, Sjoerd Wanrooij
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5768 (2021)
A central characteristic of Alzheimer’s disease (AD) and other tauopathies is the accumulation of aggregated and misfolded Tau deposits in the brain. Tau-targeting therapies for AD have been unsuccessful in patients to date. Here we show that human
Externí odkaz:
https://doaj.org/article/a9ddf524565a4f658c5be570e606a2a8
Publikováno v:
PLoS Genetics, Vol 14, Iss 3, p e1007315 (2018)
Ribonucleotides (rNMPs) are frequently incorporated during replication or repair by DNA polymerases and failure to remove them leads to instability of nuclear DNA (nDNA). Conversely, rNMPs appear to be relatively well-tolerated in mitochondrial DNA (
Externí odkaz:
https://doaj.org/article/ff328a5568ff4d1db9e664e303f9af7c
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184489 (2017)
Human PrimPol is a DNA primase/polymerase involved in DNA damage tolerance and prevents nuclear genome instability. PrimPol is also localized to the mitochondria, but its precise function in mitochondrial DNA maintenance has remained elusive. PrimPol
Externí odkaz:
https://doaj.org/article/828f67f76d3841988626f38eefda0882
Autor:
Javier Miralles Fusté, Yonghong Shi, Sjoerd Wanrooij, Xuefeng Zhu, Elisabeth Jemt, Örjan Persson, Nasim Sabouri, Claes M Gustafsson, Maria Falkenberg
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004832 (2014)
Mitochondrial DNA (mtDNA) encodes for proteins required for oxidative phosphorylation, and mutations affecting the genome have been linked to a number of diseases as well as the natural ageing process in mammals. Human mtDNA is replicated by a molecu
Externí odkaz:
https://doaj.org/article/92663004d4ff4d1cb098b79e0cf46d47
Autor:
Elizaveta O. Boldinova, Paulina H. Wanrooij, Evgeniy S. Shilkin, Sjoerd Wanrooij, Alena V. Makarova
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 7, p 1584 (2017)
PrimPol is a human deoxyribonucleic acid (DNA) polymerase that also possesses primase activity and is involved in DNA damage tolerance, the prevention of genome instability and mitochondrial DNA maintenance. In this review, we focus on recent advance
Externí odkaz:
https://doaj.org/article/02d307407014444d93be8cdec36695ab
Publikováno v:
Methods in Molecular Biology ISBN: 9781071629215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cf6840c8b780e5e477c941dddb64fa4
https://doi.org/10.1007/978-1-0716-2922-2_15
https://doi.org/10.1007/978-1-0716-2922-2_15
Autor:
Mara Doimo, Sanna Abrahamsson, Valentin L’Hôte, Mama Ndi, Rabindra Nath Das, Koit Aasumets, Andreas Berner, Steffi Goffart, Jaakko L.O. Pohjoismäki, Marcela Dávila López, Erik Chorell, Sjoerd Wanrooij
Mitochondrial DNA (mtDNA) replication stalling is considered an initial step in the formation of mtDNA deletions that associate with genetic inherited disorders and aging. However, the molecular details of how stalled replication forks lead to mtDNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9bda214bb0abccd1297c56c02bdab69
https://doi.org/10.1101/2022.06.08.495283
https://doi.org/10.1101/2022.06.08.495283
G-quadruplex (G4) DNA structures are implicated in central biological processes and are considered promising therapeutic targets because of their links to human diseases such as cancer. However, functional details of how, when, and why G4 DNA structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa44d781a5eecb11abad6512dd25a9e
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-193064
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-193064
Autor:
Sjoerd Wanrooij, Richard Lundmark, Christian Hedberg, Xin Zhou, Michael F. Albers, Lindon W. K. Moodie, Madlen Hubert
Publikováno v:
Angewandte Chemie International Edition. 58:1417-1421
Colibactin is a small molecule produced by certain bacterial species of the human microbiota that harbour the pks genomic island. Pks(+) bacteria induce a genotoxic phenotype in eukaryotic cells an ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a8fea4a28d59095d6baa23068cbd9d
https://doi.org/10.1002/anie.201812326
https://doi.org/10.1002/anie.201812326