215 Targeting ovarian carcinoma with GDT002, a first-in-class γδTCR-based T cell therapy

Autor: Esther Drent, Sabine Middendorp, Andrea Bisso, Sjoerd Baardman, Dagmar Verweij, Estefania Salcedo, Chris Coomans, Steven Braem, Sander van de Weg, Menno Meijer, Natalie Proost, Marieke van de Ven, Haakan Norell, Marleen van Loenen, Nia Emami, Sara Melief, Stefania Gobessi, Mark Throsby

Publikováno v: Regular and Young Investigator Award Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e0b3dc9baebed5236e465f132a412e8
https://doi.org/10.1136/jitc-2022-sitc2022.0215

Cell composition and expansion strategy can reduce the beneficial effect of AKT-inhibition on functionality of CD8(+) T cells

Autor: Nicolaas Schaap, Willemijn Hobo, Harry Dolstra, Anniek B. van der Waart, Aafke de Ligt, Sjoerd Baardman, Joop H. Jansen, Charlotte M. Mousset

Publikováno v: Cancer Immunology Immunotherapy, 69, 2259-2273
Cancer Immunology Immunotherapy, 69, 11, pp. 2259-2273
Cancer Immunology, Immunotherapy

AKT-inhibition is a promising approach to improve T cell therapies; however, its effect on CD4+ T cells is insufficiently explored. Previously, we and others showed that AKT-inhibition during ex vivo CD8+ T cell expansion facilitates the generation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793f601d233b0ab0111583bd9985e780
http://hdl.handle.net/2066/229379