Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Sjef Copray"'
Autor:
Reinhard Roessler, Sebastien A. Smallwood, Jesse V. Veenvliet, Petros Pechlivanoglou, Su-Ping Peng, Koushik Chakrabarty, Marian J.A. Groot-Koerkamp, R. Jeroen Pasterkamp, Evelyn Wesseling, Gavin Kelsey, Erik Boddeke, Marten P. Smidt, Sjef Copray
Publikováno v:
Stem Cell Reports, Vol 2, Iss 4, Pp 520-533 (2014)
Induced pluripotent stem cells (iPSCs) hold great promise for in vitro generation of disease-relevant cell types, such as mesodiencephalic dopaminergic (mdDA) neurons involved in Parkinson’s disease. Although iPSC-derived midbrain DA neurons have b
Externí odkaz:
https://doaj.org/article/5112638266eb46adb638fa99d734cdde
Autor:
Justin V Joseph, Ingrid A M van Roosmalen, Ellen Busschers, Tushar Tomar, Siobhan Conroy, Ellie Eggens-Meijer, Natalia Peñaranda Fajardo, Milind M Pore, Veerakumar Balasubramanyian, Michiel Wagemakers, Sjef Copray, Wilfred F A den Dunnen, Frank A E Kruyt
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145393 (2015)
Glioblastoma (GBM) is a highly infiltrative brain tumor in which cells with properties of stem cells, called glioblastoma stem cells (GSCs), have been identified. In general, the dominant view is that GSCs are responsible for the initiation, progress
Externí odkaz:
https://doaj.org/article/21fcd2628e2b4d62b7ed4ed1c898e049
Autor:
Falak Sher, Sandra Amor, Wouter Gerritsen, David Baker, Samuel L. Jackson, Erik Boddeke, Sjef Copray
Publikováno v:
Cell Transplantation, Vol 21 (2012)
In multiple sclerosis (MS), a chronic inflammatory relapsing demyelinating disease, failure to control or repair damage leads to progressive neurological dysfunction and neurodegeneration. Implantation of neural stem cells (NSCs) has been shown to pr
Externí odkaz:
https://doaj.org/article/5598e786699448cfb3e3d77eaaeac483
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40399 (2012)
BackgroundThe polycomb group protein Ezh2 is an epigenetic repressor of transcription originally found to prevent untimely differentiation of pluripotent embryonic stem cells. We previously demonstrated that Ezh2 is also expressed in multipotent neur
Externí odkaz:
https://doaj.org/article/ac1e391e4aaf453a837d53f42ddc4fa4
Autor:
Jan Koopmans, Ineke HogenEsch, Sjef Copray, Berrie Middel, Henk van Dijk, Kian-Gwan Go, Michiel Staal
Publikováno v:
Cell Transplantation, Vol 10 (2001)
In this study we examined the efficacy of cryopreserving porcine fetal mesencephalic tissue. After micro-scopical dissection of the ventral mesencephalon (VM) from E28 pig fetuses, the collection of explants was randomly divided into two equal parts.
Externí odkaz:
https://doaj.org/article/0a18b5c3c10a4bceb08c254de7a35788
Publikováno v:
Neurochemical Research. 43:2212-2223
Parkinson's disease (PD) is characterized by the presence of insoluble protein clusters containing α-synuclein. Impairment of mitochondria, endoplasmic reticulum, autophagy and intracellular trafficking proper function has been suggested to be cause
Autor:
Wolfgang Brück, Marjolein Bijlard, Yolanda A. Kap, Erik Boddeke, Wia Baron, Sjef Copray, Bert A. 't Hart, Ilia D. Vainchtein, Jeroen Kuipers, Ietje Mantingh-Otter, Arun Thiruvalluvan, Ben N G Giepmans, Marcin Czepiel
Publikováno v:
Stem Cells Translational Medicine, 5(11), 1550-1561. Wiley
Fast remyelination by endogenous oligodendrocyte precursor cells (OPCs) is essential to prevent axonal and subsequent retrograde neuronal degeneration in demyelinating lesions in multiple sclerosis (MS). In chronic lesions, however, the remyelination
Autor:
Su-Ping Peng, Sjef Copray
Publikováno v:
Stem Cell Reviews
Stem Cell Reviews and Reports, 12(1), 105-120. SPRINGER
Stem Cell Reviews and Reports, 12(1), 105-120. SPRINGER
Neuronal degeneration within the substantia nigra and the loss of the dopaminergic nigro-striatal pathway are the major hallmarks of Parkinson's disease (PD). Grafts of foetal ventral mesencephalic (VM) dopaminergic (DA) neurons into the striatum hav
Autor:
Steven Bergink, Paola Conforti, Sjef Copray, Azra Fatima, Lara Barazzuol, Seda Koyuncu, Harm H. Kampinga, David Vilchez, Rob Bakels, Eduardo Preusser de Mattos, Jeanette F. Brunsting, Despina Serlidaki, Erik H.W.G. Boddeke, Elena Cattaneo, Arun Thiruvalluvan
Publikováno v:
Molecular Cell, 78(2), 346-+. CELL PRESS
Summary CAG-repeat expansions in at least eight different genes cause neurodegeneration. The length of the extended polyglutamine stretches in the corresponding proteins is proportionally related to their aggregation propensity. Although these protei
Publikováno v:
Glia. 63:513-530
Studies on myelination and oligodendrocyte development are inevitably linked with demyelinating conditions such as multiple sclerosis (MS), leukodystrophies or spinal cord injury (SCI). Chronic loss of myelin, subsequently leading to neurodegeneratio