Transcription factor 7-like 2 gene links increased in vivo insulin synthesis to type 2 diabetes

Autor: Sjaam Jainandunsing, H. Rita Koole, Joram N.I. van Miert, Trinet Rietveld, J.L. Darcos Wattimena, Eric J.G. Sijbrands, Felix W.M. de Rooij

Publikováno v: EBioMedicine, Vol 30, Iss , Pp 295-302 (2018)

Transcription factor 7-like 2 (TCF7L2) is the main susceptibility gene for type 2 diabetes, primarily through impairing the insulin secretion by pancreatic β cells. However, the exact in vivo mechanisms remain poorly understood. We performed a famil

Externí odkaz: https://doaj.org/article/36e579999d6240f29c3b34791b027624

Unraveling, contributing factors to the severity of postprandial hypoglycemia after gastric bypass surgery

Autor: David Herzig, Michele Schiavon, Afroditi Tripyla, Vera Lehmann, Jasmin Meier, Sjaam Jainandunsing, Christina Kuenzli, Thomas P. Stauffer, Chiara Dalla Man, Lia Bally

Publikováno v: Herzig, David; Schiavon, Michele; Tripyla, Afroditi; Lehmann, Vera; Meier, Jasmin; Jainandunsing, Sjaam; Kuenzli, Christina; Stauffer, Thomas P; Dalla Man, Chiara; Bally, Lia (2023). Unraveling, contributing factors to the severity of postprandial hypoglycemia after gastric bypass surgery. Surgery for obesity and related diseases, 19(5), pp. 467-472. Elsevier 10.1016/j.soard.2022.10.037

BACKGROUND Despite the increasing prevalence of postbariatric hypoglycemia (PBH), a late metabolic complication of bariatric surgery, our understanding of its diverse manifestations remains incomplete. OBJECTIVES To contrast parameters of glucose-ins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5654d82e4c4d8c2006b9550ff5206d72
https://doi.org/10.1016/j.soard.2022.10.037

HDL associates with insulin resistance and beta-cell dysfunction in South Asian families at risk of type 2 diabetes

Autor: A. Touw, F W M de Rooij, L. van der Zee, R. Yahya, Adrie J.M. Verhoeven, Eric J.G. Sijbrands, Monique T. Mulder, M. Rashid, Sjaam Jainandunsing

Publikováno v: Journal of Diabetes and its Complications, 35(10):107993. Elsevier Inc.

Objective: Dyslipidemia precedes type 2 diabetes (T2D) and worsens with increasing glucose intolerance. First degree relatives of T2D patients have an increased risk to develop dyslipidemia and glucose intolerance. The aim of the present study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0558772018efa62eae11ca14e434be2c
https://doi.org/10.1016/j.jdiacomp.2021.107993

Failing beta-cell adaptation in South Asian families with a high risk of type 2 diabetes

Autor: T. Rietveld, Aaron Isaacs, Sjaam Jainandunsing, Janneke G. Langendonk, Behiye Özcan, Eric J.G. Sijbrands, Felix W. M. de Rooij, Joram N. I. van Miert

Publikováno v: Acta Diabetologica
Acta Diabetologica, 52(1), 11-19. Springer-Verlag Italia
Acta Diabetologica, 52(1), 11-9. Springer

We performed an extended oral glucose tolerance test (OGTT) to investigate the relationship between early and late beta-cell response and type 2 diabetes (T2D) in families of South Asian origin and indigenous Dutch, burdened by T2D. Based on the OGTT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252ff5c9ee25c66bb4b7b4384d09f0e7
http://europepmc.org/articles/PMC4340485

The Relationship of Metabolic Syndrome Traits with Beta-Cell Function and Insulin Sensitivity by Oral Minimal Model Assessment in South Asian and European Families Residing in the Netherlands

Autor: Sjaam Jainandunsing, Behiye Özcan, Eric J.G. Sijbrands, Alexander Kokkinos, Thekla Geragotou, Felix W. M. de Rooij, Nicholas Tentolouris

Publikováno v: Journal of Diabetes Research, Vol 2016 (2016)
Journal of Diabetes Research. Hindawi Limited
Journal of Diabetes Research

Background. There are different metabolic syndrome traits among patients with different ethnicities.Methods. We investigated this by studying 44 South Asians and 54 Europeans and classified them in three groups according to the occurrence of metaboli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21be50065009cbb3588be4eb8332e28c
https://doaj.org/article/6623e330d1fd4e25ab06e2810dc21d3c