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A pilocytic astrocytoma with novel ATG16L1::NTRK2 fusion responsive to larotrectinib: a case report with genomic and functional analysis.

Autor: Deland L; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.; Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden., Keane S; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden., Olsson Bontell T; Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden.; Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Sjöberg Bexelius T; Section for Pediatric Oncology, Highly Specialized Pediatric Pediatrics 1, Astrid Lindgren's Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.; Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden., Gudinaviciene I; Department of Genetics and Pathology, Laboratory Medicine Region Skåne, Lund, Sweden., De La Cuesta E; Bayer Health Care Pharmaceuticals, Inc., Whippany, NJ, United States., De Luca F; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden., Nilsson JA; Sahlgrenska Center for Cancer Research, Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Harry Perkins Institute of Medical Research, Perth, Australia., Carén H; Sahlgrenska Center for Cancer Research, Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Mörse H; Pediatric Cancer Center, Skåne University Hospital, Lund, Sweden., Abel F; Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.; Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden.

Publikováno v: The oncologist [Oncologist] 2024 Sep 26. Date of Electronic Publication: 2024 Sep 26.