Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Sj, Tyler"'
Autor:
SJ Tyler, Tilo Kunath, Shelley J Allen, Gilles Bru-Mercier, Jihoon Jo, Lucy A. Crompton, Jennifer L Badger, Maeve A. Caldwell, Kwangwook Cho, Hannah Taylor, Peter A. Barbuti, Talitha L Kerrigan, Meg L Byrne
Basal forebrain cholinergic neurons (bfCNs) which provide innervation to the hippocampus and cortex, are required for memory and learning, and are primarily affected in Alzheimer's Disease (AD), resulting in related cognitive decline. Therefore gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c48306af86a6a1f0dfc910fdda9c41ea
https://ora.ox.ac.uk/objects/uuid:2cef6ff4-2d3f-4cd9-a781-7738c7bae684
https://ora.ox.ac.uk/objects/uuid:2cef6ff4-2d3f-4cd9-a781-7738c7bae684
Autor:
Anthony R. Clarke, Shelley J Allen, David Dawbarn, GS Bennett, Gordon K. Wilcock, SJ Tyler, Vipin Asopa, Stephanie K.F. Smith, Alan G.S. Robertson, Paul H. Holden, Susan D. Brain
Publikováno v:
University of Bristol-PURE
Nerve growth factor (NGF) is involved in the development and maintenance of the nervous system. NGF binds with high affinity to the extracellular region of the tyrosine kinase receptor TrkA. This domain comprises leucine and cysteine rich motifs, fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c477ee245a202417c3e8edad930ae5
https://doi.org/10.1038/nbt0797-668
https://doi.org/10.1038/nbt0797-668
Autor:
Judy J Burston, Gordon K. Wilcock, Shelley J Allen, Alan G.S. Robertson, Anthony R. Clarke, Ruth L Naylor, SJ Tyler, Richard B. Sessions, Grant G.F Mason, David Dawbarn
TrkB is a member of the Trk family of tyrosine kinase receptors. In vivo, the extracellular region of TrkB is known to bind, with high affinity, the neurotrophin protein brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4). We describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e910b7be16ba81ab0667c326fded8eba
https://ora.ox.ac.uk/objects/uuid:8071e6e6-a4f4-46e9-bd63-59e6c6ec096b
https://ora.ox.ac.uk/objects/uuid:8071e6e6-a4f4-46e9-bd63-59e6c6ec096b
Autor:
SJ Tyler, SH MacGowan, Skf Smith, Shelley J Allen, David Dawbarn, Ags Robertson, Gordon K. Wilcock, PH Holden
Publikováno v:
University of Bristol-PURE
Apolipoprotein E (ApoE) is a potent risk factor for Alzheimer's disease. Since the loss of cholinergic function in Alzheimer's disease is known to occur at an early stage in the disease we have examined this function in normal subjects with an Apoeps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808ac6dfc6c35958138f73356f28c1c3
https://doi.org/10.1016/s0304-3940(97)00872-0
https://doi.org/10.1016/s0304-3940(97)00872-0
Publikováno v:
International journal of oncology. 7(3)
Chromosome 11p15 has been suggested to be a potential site for a second Wilms' tumour gene (a childhood nephroblastoma). Human foetal kidney cells and normal kidney cells from Wilms' tumour patients were transformed with SV40 derivative vectors. As s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18601c7fb7de30e3b8309e7eab9da3ec
https://pubmed.ncbi.nlm.nih.gov/21552882
https://pubmed.ncbi.nlm.nih.gov/21552882
Autor:
Oliver Clewes, Shelley J Allen, Caterina Catania, Heon Seok, Judy J. Watson, David Dawbarn, SJ Tyler, Kwangwook Cho, Mark S. Fahey
Publikováno v:
Journal of Neurochemistry.
Nerve growth factor (NGF) promotes cell survival via binding to the tyrosine kinase receptor A (TrkA). Its precursor, proNGF, binds to p75(NTR) and sortilin receptors to initiate apoptosis. Current disagreement exists over whether proNGF acts neurotr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94676874358431dfbcdce6aeec88e013
https://doi.org/10.1111/j.1471-4159.2008.05698.x
https://doi.org/10.1111/j.1471-4159.2008.05698.x
Autor:
L. Brady, SJ Tyler, Mark S. Fahey, R. Zhang, Deborah K. Shoemark, D Dawbarn, Shelley J Allen, Judy J. Watson, Christine L. Willis, Richard B. Sessions
Publikováno v:
Biochemical Society transactions. 34(Pt 4)
Biochemical studies have shown that domain 5 of the TrkA (tropomyosin receptor kinase A) receptor is involved in the binding of NGF (nerve growth factor). Crystallographic studies have confirmed this, demonstrating that one homodimer of NGF binds to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf6aa7ab0c2d43d859164b49b746ca7
https://pubmed.ncbi.nlm.nih.gov/16856868
https://pubmed.ncbi.nlm.nih.gov/16856868
Publikováno v:
Journal of biochemical and biophysical methods. 47(3)
Nerve growth factor (NGF) has been suggested to be of therapeutic benefit to patients with Alzheimer’s disease. One of the early changes in this disease is a loss of cholinergic function within the brain, and NGF is able to rescue cholinergic neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d3fc819525e7695234e3c2dedbe9b6
https://pubmed.ncbi.nlm.nih.gov/11245895
https://pubmed.ncbi.nlm.nih.gov/11245895
Autor:
Ags, Robertson, Richard Sessions, Mj, Banfield, Ja, Dando, Ggf, Mason, Ph, Holden, Shelley Allen, Sj, Tyler, Jj, Burston, Rl, Naylor, Gk, Wilcock, Rl, Brady, Dawbarn, D.
Publikováno v:
University of Bristol-PURE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0a8bcd60f236e3cbc2ebd1bc9df032be
https://research-information.bris.ac.uk/en/publications/e6e1a4ef-c995-4d8b-9e01-9367641e7588
https://research-information.bris.ac.uk/en/publications/e6e1a4ef-c995-4d8b-9e01-9367641e7588
Publikováno v:
University of Bristol-PURE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::52b94913e9e3b0a263165092a592a175
https://research-information.bris.ac.uk/en/publications/59bb1484-934c-460f-8c43-22f6348a33c2
https://research-information.bris.ac.uk/en/publications/59bb1484-934c-460f-8c43-22f6348a33c2