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Rivaroxaban limits complement activation compared with warfarin in antiphospholipid syndrome patients with venous thromboembolism

Autor: David A. Isenberg, Hannah Cohen, Sj Machin, Maria Efthymiou, I. J. Mackie, Deepa R. J. Arachchillage, A Chitolie, Munther A. Khamashta, Beverley J. Hunt

Publikováno v: Journal of Thrombosis and Haemostasis. 14:2177-2186

Essentials Complement activation has a pathogenic role in thrombotic antiphospholipid syndrome (APS). Coagulation proteases such as factor Xa can activate complement proteins. Complement activation markers were elevated in anticoagulated thrombotic A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f83a8b46d3adcea7a42f868e25715e
https://doi.org/10.1111/jth.13475

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ICSH recommendations for the standardization of nomenclature and grading of peripheral blood cell morphological features

Autor: Gillian Rozenberg, Carol Briggs, John Burthem, Sj Machin, Stefanie McFadden, Gina Zini, L Palmer, Maria Proytcheva

Publikováno v: International Journal of Laboratory Hematology. 37:287-303

These guidelines provide information on how to reliably and consistently report abnormal red blood cells, white blood cells and platelets using manual microscopy. Grading of abnormal cells, nomenclature and a brief description of the cells are provid

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https://doi.org/10.1111/ijlh.12327

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A phenotype–genotype correlation of ADAMTS13 mutations in congenital thrombotic thrombocytopenic purpura patients treated in the United Kingdom

Autor: Sj Machin, Mari Thomas, Raymond Camilleri, K. Manns, I. J. Mackie, W. Chen, Marie Scully, R. Liesner

Publikováno v: Journal of Thrombosis and Haemostasis. 10:1792-1801

Background: ADAMTS13 mutations play a role in thrombotic thrombocytopenic purpura (TTP) pathogenesis. Objectives: To establish a phenotype-genotype correlation in a cohort of congenital TTP patients. Patients/Methods: Clinical history and ADAMTS13 ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c19785d945f98af95f3eee04229d416
https://doi.org/10.1111/j.1538-7836.2012.04852.x

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Guidelines on the investigation and management of antiphospholipid syndrome

Autor: Hannah Cohen, Mike Greaves, I. J. Mackie, Sj Machin

Publikováno v: British Journal of Haematology. 157:47-58

This guidance updates and replaces the previous guideline on the investigation and management of antiphospholipid syndrome (APS) published in 2000 (Greaves et al, 2000), though where there have not been changes we refer back to them when appropriate.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::058e9a02782a460142da9d1e1b8f1581
https://doi.org/10.1111/j.1365-2141.2012.09037.x

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Two-centre evaluation of the Abbott CD3500 blood counter

Autor: S A al-Ismail, D Grant, A B Carter, K G Patterson, M Popeck, Y Pollard, K Bond, K J Pearman, Sj Machin

Publikováno v: Clinical & Laboratory Haematology. 17:11-21

The CD3500 blood counter (Abbott Laboratories) is a 33 parameter fully automated blood counter that produces a five part differential count with flagging of leucocyte abnormalities. In this evaluation excellent correlation between CD3500 and Coulter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3767a5b0db0e85182c5ca6884b445424
https://doi.org/10.1111/j.1365-2257.1995.tb00311.x

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Platelet aggregation is inhibited by a nitric oxide-like factor released from human neutrophils in vitro

Autor: R Faint, I. J. Mackie, Sj Machin

Publikováno v: British Journal of Haematology. 77:539-545

Summary. Thrombin-induced platelet aggregation was inhibited in vitro by washed human neutrophils. Aggregation was inhibited in a neutrophil concentration dependent manner but glutaraldehyde fixed neutrophils had no significant effect on platelet agg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88067243d4b1e4585a7049e55b5c4ed9
https://doi.org/10.1111/j.1365-2141.1991.tb08623.x

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HTLV-III antibody and T-cell subset ratios in haemophiliacs and their spouses

Autor: Sj Machin, R. M. R. Barnes, G. C. Turner, M. J. Galloway, Mark Winter, Richard S. Tedder, B. A. Mcverry, P. Evans, K. Mccarthy, R. Cheingsong-Popov

Publikováno v: British Journal of Haematology. 63:347-352

44% of 63 British patients with either haemophilia A or B were HTLV-III antibody positive (HTLV-VIII+). HTLV-III+ was more frequent in high factor VIII concentrate users and 75% of severely affected haemophilia A patients were HTLV-III+. All eight pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37755fa3b745d990da25c036dd173134
https://doi.org/10.1111/j.1365-2141.1986.tb05558.x

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Thrombotic thrombocytopaenic purpura in HIV-infected patients

Autor: Sj Machin, Hannah Cohen, Robert F. Miller, Sherie Roedling, Simon Edwards, Marie Scully, Richard D. Starke

Publikováno v: International Journal of STD & AIDS. 16:538-545

Thrombotic thrombocytopaenic purpura (TTP) results from deficiency of von Willebrand factor-cleaving protease (vWF-cp) activity. Eight HIV-infected patients presented with TTP, representing 12.5% of all TTP treated at this centre. In four patients pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781e0dc39eb728d1b0a1cc6d10dbe58e
https://doi.org/10.1258/0956462054679241

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