N-ras mutations in adult de novo acute myelogenous leukemia: prevalence and clinical significance

Autor: JP Radich, KJ Kopecky, CL Willman, J Weick, D Head, F Appelbaum, SJ Collins

Publikováno v: Blood. 76:801-807

Point mutations of the N-ras proto-oncogenes have been previously detected in 20% to 60% of samples of acute myelogenous leukemia (AML), but the clinical significance of these mutations is presently unclear. We directly sequenced polymerase chain rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b87bae3bf2412c5286acfd94f4acc07
https://doi.org/10.1182/blood.v76.4.801.bloodjournal764801

Retinoic acid-resistant HL-60R cells harbor a point mutation in the retinoic acid receptor ligand-binding domain that confers dominant negative activity

Autor: KA Robertson, B Emami, SJ Collins

Publikováno v: Blood. 80(8)

Retinoic acid (RA) induces granulocytic differentiation of acute promyelocytic leukemia (APL) cells and is a useful therapeutic agent for patients with this disease. In the HL-60 promyelocytic leukemia cell line, this RA-induced granulocytic differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8160045051ff42ef749bb7045d0c46f1
https://pubmed.ncbi.nlm.nih.gov/27089249

Retinoic acid receptors in myeloid leukemia: characterization of receptors in retinoic acid-resistant K-562 cells

Autor: KA Robertson, L Mueller, SJ Collins

Publikováno v: Blood. 77(2)

Although mRNA for the retinoic acid receptor alpha (RAR-alpha) is expressed in many different myeloid leukemias, most of these leukemia cells exhibit little if any phenotypic response when exposed to retinoic acid (RA). To determine whether such RA r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50dff050c539e9cc8bfe4ad6de9ed3db
https://pubmed.ncbi.nlm.nih.gov/1670759

Chronic myelogenous leukemia: amplification of a rearranged c-abl oncogene in both chronic phase and blast crisis

Autor: SJ Collins, MT Groudine

Publikováno v: Blood. 69(3)

The specific genetic events that distinguish the blast crisis from the chronic phase cells of chronic myelogenous leukemia (CML) are unknown. The most common karyotypic change that occurs as CML evolves from chronic phase to blast crisis is the devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8161e317e9037556b792c0276768cf
https://pubmed.ncbi.nlm.nih.gov/3545323

Combining neuropsychological assessment and structural neuroimaging to identify early Alzheimer's disease in a memory clinic cohort.

Autor: Quek YE; Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Victoria, Australia., Fung YL; Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Victoria, Australia., Bourgeat P; The Australian e-Health Research Centre, CSIRO Health and Biosecurity, Herston, Queensland, Australia., Vogrin SJ; Department of Clinical Neurosciences, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia., Collins SJ; Department of Clinical Neurosciences, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.; Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia., Bowden SC; Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Victoria, Australia.; Department of Clinical Neurosciences, St. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.

Publikováno v: Brain and behavior [Brain Behav] 2024 May; Vol. 14 (5), pp. e3505.