Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Siwaporn Mitruk"'
Autor:
Chonlaphat Sukasem, Siwaporn Mitruk, Kiat Ruxrungtham, Kanokrat Rungtivasuwan, Anchalee Avihingsanon, Narukjaporn Thammajaruk, Baralee Punyawudho, David M. Burger
Publikováno v:
Pharmacogenomics, 18, 16, pp. 1481-1490
Pharmacogenomics, 18, 1481-1490
Pharmacogenomics, 18, 1481-1490
Item does not contain fulltext AIM: To develop a population pharmacokinetic model and identify sources of variability, genetic and nongenetic factors, of tenofovir. METHODS: The ABCC2 and ABCC4 polymorphisms were genotyped in 342 patients. A nonlinea
Autor:
Siwaporn Mitruk, David M. Burger, Kanokrat Rungtivasuwan, Narukjaporn Thammajaruk, Kiat Ruxrungtham, Anchalee Avihingsanon, Baralee Punyawudho, Thitima Pengsuparp
Publikováno v:
Antimicrobial Agents and Chemotherapy, 59, 6, pp. 3240-5
Antimicrobial Agents and Chemotherapy, 59, 3240-5
Antimicrobial Agents and Chemotherapy, 59, 3240-5
Tenofovir (TFV) is eliminated by renal excretion, which is mediated through multidrug-resistant protein 2 (MRP2) and MRP4, encoded by ABCC2 and ABCC4 , respectively. Genetic polymorphisms of these transporters may affect the plasma concentrations of