Výsledky vyhledávání - "Siw Johannesen"

Akademický článek

Direct Potential Modulation of Neurogenic Differentiation Markers by Granulocyte-Colony Stimulating Factor (G-CSF) in the Rodent Brain

Autor: Judith Kozole, Rosmarie Heydn, Eva Wirkert, Sabrina Küspert, Ludwig Aigner, Tim-Henrik Bruun, Ulrich Bogdahn, Sebastian Peters, Siw Johannesen

Publikováno v: Pharmaceutics, Vol 14, Iss 9, p 1858 (2022)

The hematopoietic granulocyte-colony stimulating growth factor (G-CSF, filgrastim) is an approved drug in hematology and oncology. Filgrastim’s potential in neurodegenerative disorders is gaining increasingly more attention, as preclinical and earl

Externí odkaz: https://doaj.org/article/48ea725e297d4d17a8c56b9b2acc7c1a

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Akademický článek

Modeling and Bioinformatics Identify Responders to G-CSF in Patients With Amyotrophic Lateral Sclerosis

Publikováno v: Frontiers in Neurology, Vol 12 (2021)

Objective: Developing an integrative approach to early treatment response classification using survival modeling and bioinformatics with various biomarkers for early assessment of filgrastim (granulocyte colony stimulating factor) treatment effects i

Externí odkaz: https://doaj.org/article/c8a0a4926f5a47ebb2565cfb2991fa69

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Akademický článek

Targeting TGF-ß in the Central Nervous System: Assessment of Cynomolgus Monkey—Toxicity and Pharmacokinetics for an LNA-Antisense Oligonucleotide

Autor: Sebastian Peters, Eva Wirkert, Sabrina Kuespert, Rosmarie Heydn, Sven Korte, Lars Mecklenburg, Ludwig Aigner, Siw Johannesen, Tim-Henrik Bruun, Ulrich Bogdahn

Publikováno v: Applied Sciences, Vol 12, Iss 3, p 973 (2022)

Increasingly antisense oligonucleotides (ASOs) are developed for potential treatment of CNS disorders, and due to the inability to cross the blood brain barrier, they require direct administration into the cerebrospinal fluid (CSF). In this regard, i

Externí odkaz: https://doaj.org/article/4027f861493a47a29d8001e8f86f1eb9

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Akademický článek

Safe and Effective Cynomolgus Monkey GLP—Tox Study with Repetitive Intrathecal Application of a TGFBR2 Targeting LNA-Gapmer Antisense Oligonucleotide as Treatment Candidate for Neurodegenerative Disorders

Autor: Sebastian Peters, Eva Wirkert, Sabrina Kuespert, Rosmarie Heydn, Siw Johannesen, Anita Friedrich, Susanne Mailänder, Sven Korte, Lars Mecklenburg, Ludwig Aigner, Tim-Henrik Bruun, Ulrich Bogdahn

Publikováno v: Pharmaceutics, Vol 14, Iss 1, p 200 (2022)

The capability of the adult central nervous system to self-repair/regenerate was demonstrated repeatedly throughout the last decades but remains in debate. Reduced neurogenic niche activity paralleled by a profound neuronal loss represents fundamenta

Externí odkaz: https://doaj.org/article/2be091cb44884b99a0ace5ee62d10f3a

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Akademický článek

Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2—A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling

Autor: Sabrina Kuespert, Rosmarie Heydn, Sebastian Peters, Eva Wirkert, Anne-Louise Meyer, Mareile Siebörger, Siw Johannesen, Ludwig Aigner, Ulrich Bogdahn, Tim-Henrik Bruun

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 6, p 1952 (2020)

Antisense Oligonucleotides (ASOs) are an emerging drug class in gene modification. In our study we developed a safe, stable, and effective ASO drug candidate in locked nucleic acid (LNA)-gapmer design, targeting TGFβ receptor II (TGFBR2) mRNA. Disco

Externí odkaz: https://doaj.org/article/7b458612d8254c0e8aebceb9b9f7159e

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Akademický článek

Biomarker Supervised G-CSF (Filgrastim) Response in ALS Patients

Autor: Siw Johannesen, Bettina Budeus, Sebastian Peters, Sabine Iberl, Anne-Louise Meyer, Tina Kammermaier, Eva Wirkert, Tim-Henrik Bruun, Verena C. Samara, Wilhelm Schulte-Mattler, Wolfgang Herr, Armin Schneider, Jochen Grassinger, Ulrich Bogdahn

Publikováno v: Frontiers in Neurology, Vol 9 (2018)

Objective: To evaluate safety, tolerability and feasibility of long-term treatment with Granulocyte-colony stimulating factor (G-CSF), a well-known hematopoietic stem cell factor, guided by assessment of mobilized bone marrow derived stem cells and c

Externí odkaz: https://doaj.org/article/b0c68c2967a24ac0b019b44d17b6b76b

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Akademický článek

Combinatory Biomarker Use of Cortical Thickness, MUNIX, and ALSFRS-R at Baseline and in Longitudinal Courses of Individual Patients With Amyotrophic Lateral Sclerosis

Autor: Anna M. Wirth, Andrei Khomenko, Dobri Baldaranov, Ines Kobor, Ohnmar Hsam, Thomas Grimm, Siw Johannesen, Tim-Henrik Bruun, Wilhelm Schulte-Mattler, Mark W. Greenlee, Ulrich Bogdahn

Publikováno v: Frontiers in Neurology, Vol 9 (2018)

Objective: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative process affecting upper and lower motor neurons as well as non-motor systems. In this study, precentral and postcentral cortical thinning detected by structural magneti

Externí odkaz: https://doaj.org/article/d35ddb4e1d6b415b896fe5390ed0dff4

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Akademický článek

The TGF-β System As a Potential Pathogenic Player in Disease Modulation of Amyotrophic Lateral Sclerosis

Autor: Sebastian Peters, Eva Zitzelsperger, Sabrina Kuespert, Sabine Iberl, Rosmarie Heydn, Siw Johannesen, Susanne Petri, Ludwig Aigner, Dietmar R. Thal, Andreas Hermann, Jochen H. Weishaupt, Tim-Henrik Bruun, Ulrich Bogdahn

Publikováno v: Frontiers in Neurology, Vol 8 (2017)

Amyotrophic lateral sclerosis (ALS) represents a fatal orphan disease with high unmet medical need, and a life time risk of approx. 1/400 persons per population. Based on increasing knowledge on pathophysiology including genetic and molecular changes

Externí odkaz: https://doaj.org/article/d058721d2002498e98efced3074ddb08

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