Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sivert Bjurström"'
Autor:
Anna Nilsson, Benita Forngren, Sivert Bjurström, Richard J A Goodwin, Elisa Basmaci, Ingela Gustafsson, Anita Annas, Dennis Hellgren, Alexander Svanhagen, Per E Andrén, Johan Lindberg
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47353 (2012)
Drug toxicity observed in animal studies during drug development accounts for the discontinuation of many drug candidates, with the kidney being a major site of tissue damage. Extensive investigations are often required to reveal the mechanisms under
Externí odkaz:
https://doaj.org/article/da12f973b7de43c99eab0949895a5b4a
Autor:
Johan Bylund, Håkan Andersson, Anita Annas, Dennis Hellgren, Sivert Bjurström, Alexander Svanhagen
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 41(3)
A novel microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor induced kidney injury at exposures representing less than 4 times the anticipated efficacious exposure in man during a 7-day toxicity study in rats. The findings consisted mainly of tu
Autor:
Guy Healing, Stefan Carlsson, Inger Skånberg, David B. Stong, Ronny Fransson-Steen, Sivert Bjurström
Publikováno v:
International journal of toxicology. 31(4)
The results of 18 months mouse and 24 months rat carcinogenicity studies with the oral direct thrombin inhibitor ximelagatran are presented. In the mouse, gavage doses of ximelagatran up to 180 μmol/kg per d produced no neoplastic changes in any of
Autor:
Alexander Svanhagen, Johan Lindberg, Dennis Hellgren, Per E. Andrén, Richard J. A. Goodwin, Sivert Bjurström, Elisa Basmaci, Benita Forngren, Anna Nilsson, Anita Annas, Ingela Gustafsson
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 10, p e47353 (2012)
PLoS ONE, Vol 7, Iss 10, p e47353 (2012)
Drug toxicity observed in animal studies during drug development accounts for the discontinuation of many drug candidates, with the kidney being a major site of tissue damage. Extensive investigations are often required to reveal the mechanisms under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5396306d73a27c930b349f06dc12f42
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-186048
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-186048
Autor:
Daniel Potenta, Arthur Roth, Lewis B. Kinter, Carl L. Alden, Thomas Singer, Charles R. Mahrt, Joseph J. DeGeorge, Andrew R. Kraynak, John Evans, Bruce A. Trela, Richard Perry, Ronny Fransson-Steen, Jochen Woicke, Rabih Slim, Susan E. Turnquist, Matt Liu, David Brewster, Sandra De Jonghe, Karyn Colman, Douglas A. Keller, Vanessa Bosmans, Oliver C. Turner, Mark A. Dominick, Sivert Bjurström, M. Vijayaraj Reddy, James R. Hailey, Richard D. Storer, Frank D. Sistare, James R. Myer, Marjolein van Heerden, Keith A. Soper, Philip Sherratt, Daniel Morton, James H. Stoltz, Joel Christensen, Dirk Mariën, Jean-Guy Bienvenu
Publikováno v:
Toxicologic pathology. 39(4)
Data collected from 182 marketed and nonmarketed pharmaceuticals demonstrate that there is little value gained in conducting a rat two-year carcinogenicity study for compounds that lack: (1) histopathologic risk factors for rat neoplasia in chronic t
Autor:
Sivert Bjurström, Rolf Larsson, Håkan Björklund, Mats Spångberg, Eva Lydahl, Ingemar Kihlström
Publikováno v:
Journal of Cataract and Refractive Surgery. 16:170-177
To evaluate the long-term biocompatibility and potential side effects of heparin surface modification of a poly(methyl methacrylate) intraocular lens (IOL), a heparin surface modified IOL was implanted in the left posterior chamber of 24 cynomolgus m
Autor:
Anna Karin Gerdin, Michael Snaith, Alaa Saad, Ronny Fransson-Steen, Meint Schuelke, Elisabeth Jensen Lundgren, Vikas V. Surve, Mohammad Bohlooly-Y, Sivert Bjurström, Anne Edenro, Mikael Bjursell, Jan Törnell, Anna-Lena Berg, Marie Jönsson, Maria Björkman
Publikováno v:
Biochemical and biophysical research communications. 349(2)
Using the mouse as a model organism in pharmaceutical research presents unique advantages as its physiology in many ways resembles the human physiology, it also has a relatively short generation time, low breeding and maintenance costs, and is availa
Autor:
Anita Annas, Anna Nilsson, Alexander Svanhagen, Håkan Andersson, Dennis Hellgren, Per E. Andrén, Sivert Bjurström, Benita Forngren, Johan Lindberg
Publikováno v:
Toxicology Letters. 211:S149
Autor:
Ingrid Sjögren, Sivert Bjurström
Publikováno v:
Experimental and Toxicologic Pathology. 57:333
Publikováno v:
Pharmacology & Toxicology. 63:257-261
Pigs, crossbreeds of Swedish Landrace and Yorkshire, females and castrated males about 6 months old, were exposed to experimental stress. The pigs were either considered normal or shown to be susceptible to develop malignant hyperthermia when tested