Zobrazeno 1 - 10 of 138 pro vyhledávání: '"Siver A, Moestue"'
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Akademický článek
Argininosuccinate lyase is a metabolic vulnerability in breast development and cancer
Autor: Sigurdur Trausti Karvelsson, Qiong Wang, Bylgja Hilmarsdottir, Arnar Sigurdsson, Siver Andreas Moestue, Gunhild Mari Mælandsmo, Skarphedinn Halldorsson, Steinn Gudmundsson, Ottar Rolfsson
Publikováno v: npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract Epithelial-to-mesenchymal transition (EMT) is fundamental to both normal tissue development and cancer progression. We hypothesized that EMT plasticity defines a range of metabolic phenotypes and that individual breast epithelial metabolic p
Externí odkaz: https://doaj.org/article/cdfa07e4bd6d4ad0a6994536dab48cac
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2
Akademický článek
Detection of phenotype‐specific therapeutic vulnerabilities in breast cells using a CRISPR loss‐of‐function screen
Autor: Anna Barkovskaya, Craig M. Goodwin, Kotryna Seip, Bylgja Hilmarsdottir, Solveig Pettersen, Clint Stalnecker, Olav Engebraaten, Eirikur Briem, Channing J. Der, Siver A. Moestue, Thorarinn Gudjonsson, Gunhild M. Mælandsmo, Lina Prasmickaite
Publikováno v: Molecular Oncology, Vol 15, Iss 8, Pp 2026-2045 (2021)
Cellular phenotype plasticity between the epithelial and mesenchymal states has been linked to metastasis and heterogeneous responses to cancer therapy, and remains a challenge for the treatment of triple‐negative breast cancer (TNBC). Here, we use
Externí odkaz: https://doaj.org/article/0cf47b80942b4dccb4f54632467c29f1
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3
Akademický článek
Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer
Autor: Maria T. Grinde, Bylgja Hilmarsdottir, Hanna Maja Tunset, Ida Marie Henriksen, Jana Kim, Mads H. Haugen, Morten Beck Rye, Gunhild M. Mælandsmo, Siver A. Moestue
Publikováno v: Breast Cancer Research, Vol 21, Iss 1, Pp 1-13 (2019)
Abstract Introduction Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 has shown promising
Externí odkaz: https://doaj.org/article/d8b0d0d0cd0e45d1b4bea9d5fd2b95b4
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4
Akademický článek
Detection of Recurrent Prostate Cancer With 18F-Fluciclovine PET/MRI
Autor: Kirsten Margrete Selnæs, Brage Krüger-Stokke, Mattijs Elschot, Håkon Johansen, Per Arvid Steen, Sverre Langørgen, Bjørg Yksnøy Aksnessæther, Gunnar Indrebø, Torill Anita Eidhammer Sjøbakk, May-Britt Tessem, Siver Andreas Moestue, Heidi Knobel, Torgrim Tandstad, Helena Bertilsson, Arne Solberg, Tone Frost Bathen
Publikováno v: Frontiers in Oncology, Vol 10 (2020)
ObjectiveSimultaneous PET/MRI combines soft-tissue contrast of MRI with high molecular sensitivity of PET in one session. The aim of this prospective study was to evaluate detection rates of recurrent prostate cancer by 18F-fluciclovine PET/MRI.Metho
Externí odkaz: https://doaj.org/article/72abee93ba91426aa8cb05864817b5aa
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5
Akademický článek
Reproducible Lipid Alterations in Patient-Derived Breast Cancer Xenograft FFPE Tissue Identified with MALDI MSI for Pre-Clinical and Clinical Application
Autor: Vanna Denti, Maria K. Andersen, Andrew Smith, Anna Mary Bofin, Anna Nordborg, Fulvio Magni, Siver Andreas Moestue, Marco Giampà
Publikováno v: Metabolites, Vol 11, Iss 9, p 577 (2021)
The association between lipid metabolism and long-term outcomes is relevant for tumor diagnosis and therapy. Archival material such as formalin-fixed and paraffin embedded (FFPE) tissues is a highly valuable resource for this aim as it is linked to l
Externí odkaz: https://doaj.org/article/e5ecc6d591bd4241866d578dd02340c9
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