Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Sivasish Sindiri"'
Autor:
Yong Li, Steven A Rosenberg, Paul F Robbins, Zhiya Yu, Maria Parkhurst, Billel Gasmi, Nikolaos Zacharakis, Todd D Prickett, Jared J Gartner, Sri Krishna, Stephanie L Goff, Satyajit Ray, Frank J Lowery, Sivasish Sindiri, Alakesh Bera, Noam Levin, Sanghyun P Kim, Charles A Marquardt, Nolan R Vale, Lior Levy, Tiffany Benzine, Robert V Masi, Rafiqul Islam
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 5 (2024)
Background Tumor-infiltrating lymphocytes (TILs) targeting neoantigens can effectively treat a selected set of metastatic solid cancers. However, harnessing TILs for cancer treatments remains challenging because neoantigen-reactive T cells are often
Externí odkaz:
https://doaj.org/article/f685ba7746d3429ab6dd6d6e8a83fc10
Autor:
Steven A Rosenberg, Maria Parkhurst, Paul Robbins, Nikolaos Zacharakis, Frank Lowery, Sri Krishna, Rami Yoseph, Neilesh Parikh, Sivasish Sindiri, Kyle J Hitscherich, Noam Levin, Aaron Dinerman
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/af95ef9b755540c2b0c0694eee5dfd28
Autor:
Yong Li, Steven A Rosenberg, Paul Robbins, Billel Gasmi, Todd D Prickett, Jared J Gartner, Devikala Gurusamy, Vid Leko, Victoria Hill, Bradley Sinclair White, Sivasish Sindiri, Shirley Nah
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 4 (2023)
Background Metastatic cholangiocarcinoma (CC), a form of gastrointestinal cancer that originates from the bile ducts, cannot be cured by currently available therapies, and is associated with dismal prognosis. In a previous case report, adoptive trans
Externí odkaz:
https://doaj.org/article/3b21eef43f154437b05b2bb444ccee1d
Autor:
Nitin Roper, Moises J. Velez, Alberto Chiappori, Yoo Sun Kim, Jun S. Wei, Sivasish Sindiri, Nobuyuki Takahashi, Deborah Mulford, Suresh Kumar, Kris Ylaya, Christopher Trindade, Irena Manukyan, Anna-Leigh Brown, Jane B. Trepel, Jung-Min Lee, Stephen Hewitt, Javed Khan, Anish Thomas
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Immune checkpoint blockade (ICB) benefits only a small subset of patients with small cell lung cancer (SCLC) and the mechanisms driving benefit are poorly understood. Here, the authors show that elevated Notch signaling predicts clinical benefit in I
Externí odkaz:
https://doaj.org/article/14cd7395b4e240a6a4c5e9753ff63101
Autor:
Nitin Roper, Anna-Leigh Brown, Jun S. Wei, Svetlana Pack, Christopher Trindade, Chul Kim, Olivia Restifo, Shaojian Gao, Sivasish Sindiri, Farid Mehrabadi, Rajaa El Meskini, Zoe Weaver Ohler, Tapan K. Maity, Abhilash Venugopalan, Constance M. Cultraro, Elizabeth Akoth, Emerson Padiernos, Haobin Chen, Aparna Kesarwala, DeeDee K. Smart, Naris Nilubol, Arun Rajan, Zofia Piotrowska, Liqiang Xi, Mark Raffeld, Anna R. Panchenko, Cenk Sahinalp, Stephen Hewitt, Chuong D. Hoang, Javed Khan, Udayan Guha
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 1, Pp 100007- (2020)
Summary: Clonal evolution of osimertinib-resistance mechanisms in EGFR mutant lung adenocarcinoma is poorly understood. Using multi-region whole-exome and RNA sequencing of prospectively collected pre- and post-osimertinib-resistant tumors, including
Externí odkaz:
https://doaj.org/article/bd88b4540b1e47469281d9cfc6d07cbc
Autor:
Guangyang Yu, Ying Pang, Mythili Merchant, Chimene Kesserwan, Vineela Gangalapudi, Abdalla Abdelmaksoud, Alice Ranjan, Olga Kim, Jun S. Wei, Hsien-Chao Chou, Xinyu Wen, Sivasish Sindiri, Young K. Song, Liqiang Xi, Rosandra N. Kaplan, Terri S. Armstrong, Mark R. Gilbert, Kenneth Aldape, Javed Khan, Jing Wu
Publikováno v:
Cancers, Vol 13, Iss 23, p 6092 (2021)
Background: A consistent correlation between tumor mutation burden (TMB) and tumor immune microenvironment has not been observed in gliomas as in other cancers. Methods: Driver germline and somatic mutations, TMB, neoantigen, and immune cell signatur
Externí odkaz:
https://doaj.org/article/70515b633a5848d3903c0451d07be498
Autor:
Myron S. Ignatius, Madeline N. Hayes, Riadh Lobbardi, Eleanor Y. Chen, Karin M. McCarthy, Prethish Sreenivas, Zainab Motala, Adam D. Durbin, Aleksey Molodtsov, Sophia Reeder, Alexander Jin, Sivasish Sindiri, Brian C. Beleyea, Deepak Bhere, Matthew S. Alexander, Khalid Shah, Charles Keller, Corinne M. Linardic, Petur G. Nielsen, David Malkin, Javed Khan, David M. Langenau
Publikováno v:
Cell Reports, Vol 19, Iss 11, Pp 2304-2318 (2017)
Tumor-propagating cells (TPCs) share self-renewal properties with normal stem cells and drive continued tumor growth. However, mechanisms regulating TPC self-renewal are largely unknown, especially in embryonal rhabdomyosarcoma (ERMS)—a common pedi
Externí odkaz:
https://doaj.org/article/faebeb2fcd654f42ab17377a17a33471
Autor:
Nitin Roper, Shaojian Gao, Tapan K. Maity, A. Rouf Banday, Xu Zhang, Abhilash Venugopalan, Constance M. Cultraro, Rajesh Patidar, Sivasish Sindiri, Anna-Leigh Brown, Alexander Goncearenco, Anna R. Panchenko, Romi Biswas, Anish Thomas, Arun Rajan, Corey A. Carter, David E. Kleiner, Stephen M. Hewitt, Javed Khan, Ludmila Prokunina-Olsson, Udayan Guha
Publikováno v:
Cell Reports, Vol 26, Iss 10, Pp 2651-2666.e6 (2019)
Summary: Intratumor mutational heterogeneity has been documented in primary non-small-cell lung cancer. Here, we elucidate mechanisms of tumor evolution and heterogeneity in metastatic thoracic tumors (lung adenocarcinoma and thymic carcinoma) using
Externí odkaz:
https://doaj.org/article/a89fb160e8244d76991306067b2f929e
Autor:
Rimas J. Orentas, Sivasish Sindiri, Christine Duris, Xinyu Wen, Jianbin He, Jun S. Wei, Jason Jarzembowski, Javed Khan
Publikováno v:
Frontiers in Oncology, Vol 7 (2017)
Adoptive immunotherapy with antibody-based therapy or with T cells transduced to express chimeric antigen receptors (CARs) is useful to the extent that the cell surface membrane protein being targeted is not expressed on normal tissues. The most succ
Externí odkaz:
https://doaj.org/article/75c0b7c48e17410ab00441e9a6489cb7
Autor:
Inês M Tenente, Madeline N Hayes, Myron S Ignatius, Karin McCarthy, Marielle Yohe, Sivasish Sindiri, Berkley Gryder, Mariana L Oliveira, Ashwin Ramakrishnan, Qin Tang, Eleanor Y Chen, G Petur Nielsen, Javed Khan, David M Langenau
Publikováno v:
eLife, Vol 6 (2017)
Rhabdomyosarcoma (RMS) is a pediatric malignacy of muscle with myogenic regulatory transcription factors MYOD and MYF5 being expressed in this disease. Consensus in the field has been that expression of these factors likely reflects the target cell o
Externí odkaz:
https://doaj.org/article/cdb12781b75a4561a7a9ff10ad882bb8