Výsledky vyhledávání - "Sivaprasad Kasturi"

Synthesis of novel cytotoxic tetracyclic acridone derivatives and study of their molecular docking, ADMET, QSAR, bioactivity and protein binding properties

Autor: Rajesh Madhu, Yogeeswari Perumal, Krishna S. Ethiraj, Mallilkarjuna Reddy Guda, Rajkumar Veligeti, Naveen Polkam, Vijaya Kumar Reddy Avula, Sivaprasad Kasturi, Hasitha Shilpa Anantaraju, Grigory V. Zyryanov, Swetha Vallela, Visweswara Rao Pasupuleti, Jaya Shree Anireddy, Srinivas Uppalanchi

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-22 (2020)
Sci. Rep.
Scientific Reports

Acridone based synthetic and natural products with inherent anticancer activity advancing the research and generating a large number of structurally diversified compounds. In this sequence we have designed, synthesized a series of tetracyclic acridon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76c07b6705f38e40b4277f9a25eb08d
https://doi.org/10.1038/s41598-020-77590-1

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Synthesis of New Heteroaryl Substituted Morpholine Tagged Triazines and Evaluation of their Cytotoxic Activity

Autor: Shubham Dwivedi, Perumal Yogeeswari, Srinivas Uppalanchi, Jaya Shree Anireddy, Sivaprasad Kasturi, Hasitha Shilpa Anantaraju, Sujatha Surarapu, Krishna S. Ethiraj

Publikováno v: Letters in Drug Design & Discovery. 15:181-192

Background: In the present study, new triazine derivatives 3, 4, 5, 6, 8 and 10 were synthesized starting from readily available cyanuric chloride 1 via nucleophilic displacement with morpholine followed by Suzuki or Stille coupling reactions and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00f242338db751ff06dab4eb1fef4995
https://doi.org/10.2174/1570180814666170605115335

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Synthesis and α-glucosidase inhibition activity of dihydroxy pyrrolidines

Autor: Sujatha Surarapu, Dilep Kumar Sigalapalli, Shubham Dwivedi, Krishna S. Ethiraj, Yogeeswari Perumal, Hasitha Shilpa Anantaraju, Srinivas Uppalanchi, Sivaprasad Kasturi, Jaya Shree Anireddy, Bathini Nagendra Babu

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 27:2818-2823

A new series of Deacetylsarmentamide A and B derivatives, amides and sulfonamides of 3,4-dihydroxypyrrolidines as α-glucosidase inhibitors were designed and synthesized. The biological screening test against α-glucosidase showed that some of these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beef29f0ccc5c589f85dfece1d0dbf5a
https://doi.org/10.1016/j.bmcl.2017.04.078

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Synthesis, molecular modeling and biological evaluation of aza-flavanones as α-glucosidase inhibitors† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7md00162b

Autor: Dilep Kumar Sigalapalli, Yogeeswari Perumal, Shubham Dwivedi, Jaya Shree Anireddy, Krishna S. Ethiraj, Srinivas Uppalanchi, Sujatha Surarapu, Bathini Nagendra Babu, Sivaprasad Kasturi, Chandra Chary Bathoju

An efficient acid catalyzed methodology has been employed to synthesize a variety of aza-flavanones and their α-glucosidase inhibitory activity is evaluated using acarbose, miglitol and voglibose as reference standards. Molecular modeling studies we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96db4bda49a5dd49262416e727d7aa9f
https://europepmc.org/articles/PMC6072087/