Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Sivaprakash Ramalingam"'
Autor:
Shweta Verma, Sujit Dalabehera, Ranjeet Maurya, Dayanidhi Singh, Bhavana Prasher, Rajesh Pandey, Sharmila Bapat, Sivaprakash Ramalingam, Chetana Sachidanandan
Publikováno v:
Stem Cell Research, Vol 78, Iss , Pp 103456- (2024)
Rubinstein Taybi Syndrome (RSTS) is a rare genetic disorder which is caused by mutations in either CREBBP or EP300. RSTS with mutations in CREBBP is known as RSTS-1. We have generated an induced pluripotent stem cell (iPSC) line, IGIBi018-A from an I
Externí odkaz:
https://doaj.org/article/f56e9f250aee4719b19b365bc52e9f1e
Autor:
Manisha Marothia, Ankita Behl, Preeti Maurya, Monika Saini, Rumaisha Shoaib, Swati Garg, Geeta Kumari, Shreeja Biswas, Akshay Munjal, Sakshi Anand, Amandeep Kaur Kahlon, Pragya Gupta, Saurav Biswas, Bidhan Goswami, Haider Thaer Abdulhameed Almuqdadi, Ipsita Pal Bhowmick, Maxim Shevtsov, Sivaprakash Ramalingam, Anand Ranganathan, Shailja Singh
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109918- (2024)
Summary: Malaria parasite invasion to host erythrocytes is mediated by multiple interactions between merozoite ligands and erythrocyte receptors that contribute toward the development of disease pathology. Here, we report a novel antigen Plasmodium p
Externí odkaz:
https://doaj.org/article/1b9eaf038955493ba63df6fb77fbaed5
Autor:
Pragya Gupta, Sangam Giri Goswami, Geeta Kumari, Vinodh Saravanakumar, Nupur Bhargava, Akhila Balakrishna Rai, Praveen Singh, Rahul C. Bhoyar, V. R. Arvinden, Padma Gunda, Suman Jain, Vanya Kadla Narayana, Sayali C. Deolankar, T. S. Keshava Prasad, Vivek T. Natarajan, Vinod Scaria, Shailja Singh, Sivaprakash Ramalingam
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Ex vivo cellular system that accurately replicates sickle cell disease and β-thalassemia characteristics is a highly sought-after goal in the field of erythroid biology. In this study, we present the generation of erythroid progenitor lines
Externí odkaz:
https://doaj.org/article/057cee76498e45b68c0e7b95f3a332c8
Autor:
Pragya Gupta, V. R. Arvinden, Priya Thakur, Rahul C. Bhoyar, Vinodh Saravanakumar, Narendra Varma Gottumukkala, Sangam Giri Goswami, Mehwish Nafiz, Aditya Ramdas Iyer, Harie Vignesh, Rajat Soni, Nupur Bhargava, Padma Gunda, Suman Jain, Vivek Gupta, Sridhar Sivasubbu, Vinod Scaria, Sivaprakash Ramalingam
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
β-hemoglobinopathies such as β-thalassemia (BT) and Sickle cell disease (SCD) are inherited monogenic blood disorders with significant global burden. Hence, early and affordable diagnosis can alleviate morbidity and reduce mortality given the lack
Externí odkaz:
https://doaj.org/article/a6cb5d12882b4757acc144143da96ca8
Autor:
Deepa Jaganathan, Raja Rajakani, Dadakhalandar Doddamani, Divya Saravanan, Shalini Pulipati, Vivek Hari Sundar G, Gothandapani Sellamuthu, Shilpha Jayabalan, Kumkum Kumari, Pavithra Parthasarathy, Punitha S., Sivaprakash Ramalingam, Padubidri V. Shivaprasad, Gayatri Venkataraman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Plant precursor miRNAs (pre-miRNA) have conserved evolutionary footprints that correlate with mode of miRNA biogenesis. In plants, base to loop and loop to base modes of biogenesis have been reported. Conserved structural element(s) in pre-m
Externí odkaz:
https://doaj.org/article/dd11cd8706044db386d0049b95af663a
Autor:
Abhinav Jain, Rahul C. Bhoyar, Kavita Pandhare, Anushree Mishra, Disha Sharma, Mohamed Imran, Vigneshwar Senthivel, Mohit Kumar Divakar, Mercy Rophina, Bani Jolly, Arushi Batra, Sumit Sharma, Sanjay Siwach, Arun G. Jadhao, Nikhil V. Palande, Ganga Nath Jha, Nishat Ashrafi, Prashant Kumar Mishra, Vidhya A.K., Suman Jain, Debasis Dash, Nachimuthu Senthil Kumar, Andrew Vanlallawma, Ranjan Jyoti Sarma, Lalchhandama Chhakchhuak, Shantaraman Kalyanaraman, Radha Mahadevan, Sunitha Kandasamy, Pabitha B. M,, Raskin Erusan Rajagopal, Ezhil Ramya J., Nirmala Devi P., Anjali Bajaj, Vishu Gupta, Samatha Mathew, Sangam Goswami, Mohit Mangla, Savinitha Prakash, Kandarp Joshi, Meyakumla, Sreedevi S., Devarshi Gajjar, Ronibala Soraisham, Rohit Yadav, Yumnam Silla Devi, Aayush Gupta, Mitali Mukerji, Sivaprakash Ramalingam, Binukumar B. K., Vinod Scaria, Sridhar Sivasubbu
Publikováno v:
Journal of Genetic Engineering and Biotechnology, Vol 19, Iss 1, Pp 1-16 (2021)
Abstract Background Autoinflammatory disorders are the group of inherited inflammatory disorders caused due to the genetic defect in the genes that regulates innate immune systems. These have been clinically characterized based on the duration and oc
Externí odkaz:
https://doaj.org/article/d37b2fc25f074d15ac6770cc2899063c
Autor:
Prabhakar Arumugam, Meghna Chauhan, Thejaswitha Rajeev, Rahul Chakraborty, Kanika Bisht, Mahima Madan, Deepthi Shankaran, Sivaprakash Ramalingam, Sheetal Gandotra, Vivek Rao
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In addition to their role in cellular energy production, mitochondria are increasingly recognized as regulators of the innate immune response of phagocytes. Here, we demonstrate that altering expression levels of the mitochondria-associated enzyme, c
Externí odkaz:
https://doaj.org/article/dc779cfd563741d3b19a4d46d6a56cc5
Publikováno v:
Journal of Fungi, Vol 8, Iss 12, p 1241 (2022)
Trichophyton rubrum is the most prevalent causative agent responsible for 80–90% of all known superficial fungal infections in humans, worldwide. Limited available methods for genetic manipulations have been one of the major bottlenecks in understa
Externí odkaz:
https://doaj.org/article/3b66d1aff9f845f2b5f2901c7e28c9d2
Autor:
Priya Thakur, Pragya Gupta, Nupur Bhargava, Rajat Soni, Narendra Varma Gottumukkala, Sangam Giri Goswami, Gaurav Kharya, Vinodh Saravanakumar, Padma Gunda, Suman Jain, Jasmita Dass, Mukul Aggarwal, Sivaprakash Ramalingam
Publikováno v:
Diagnostics, Vol 12, Iss 7, p 1765 (2022)
Sickle cell disease (SCD) is the most prevalent life-threatening blood monogenic disorder. Currently, there is no cure available, apart from bone marrow transplantation. Early and efficient diagnosis of SCD is key to disease management, which would m
Externí odkaz:
https://doaj.org/article/53809a58ee74487d832c6189943ff76d
Autor:
Priya Thakur, Nupur Bhargava, Shashank Jaitly, Pragya Gupta, Saurabh Kumar Bhattacharya, G. Padma, Saroja Kondaveeti, Suman Jain, Sivaprakash Ramalingam
Publikováno v:
Stem Cell Research, Vol 50, Iss , Pp 102124- (2021)
β-thalassemia (BT) is a hereditary blood disorder caused by mutations in the β-globin (HBB) gene leading to severely reduced or no synthesis of the β-chain of adult hemoglobin. IVS1-5 (G > C) is the most common BT mutation in Indian population and
Externí odkaz:
https://doaj.org/article/795b1d055132407c8d882c92e1711f0b