Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Sivanesan Dakshanamurthy"'
Autor:
Kush Savsani, Sivanesan Dakshanamurthy
Publikováno v:
Diseases, Vol 12, Iss 7, p 149 (2024)
Personalized cancer vaccines have emerged as a promising avenue for cancer treatment or prevention strategies. This approach targets the specific genetic alterations in individual patient’s tumors, offering a more personalized and effective treatme
Externí odkaz:
https://doaj.org/article/7ce6c1fa466f4f14853f809ec30dd4cd
Publikováno v:
Toxics, Vol 12, Iss 7, p 481 (2024)
Environmental chemicals, such as PFAS, exist as mixtures and are frequently encountered at varying concentrations, which can lead to serious health effects, such as cancer. Therefore, understanding the dose-dependent toxicity of chemical mixtures is
Externí odkaz:
https://doaj.org/article/8c0ff28ef2334161a50e699c37c90380
Publikováno v:
Bioengineering, Vol 11, Iss 4, p 322 (2024)
Previous epitope-based cancer vaccines have focused on analyzing a limited number of mutated epitopes and clinical variables preliminarily to experimental trials. As a result, relatively few positive clinical outcomes have been observed in epitope-ba
Externí odkaz:
https://doaj.org/article/44006f37b3a24c28860e072625a79330
Autor:
Enrico Bautista, Young Hyun Jung, Manuela Jaramillo, Harrish Ganesh, Aryaan Varma, Kush Savsani, Sivanesan Dakshanamurthy
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 419 (2024)
The current epitope selection methods for peptide vaccines often rely on epitope binding affinity predictions, prompting the need for the development of more sophisticated in silico methods to determine immunologically relevant epitopes. Here, we dev
Externí odkaz:
https://doaj.org/article/fad734d0d2ef42bb80e8dcdf735ab917
Autor:
Chen Shen, Anmada Nayak, Leif R. Neitzel, Amber A. Adams, Maya Silver-Isenstadt, Leah M. Sawyer, Hassina Benchabane, Huilan Wang, Nawat Bunnag, Bin Li, Daniel T. Wynn, Fan Yang, Marta Garcia-Contreras, Charles H. Williams, Sivanesan Dakshanamurthy, Charles C. Hong, Nagi G. Ayad, Anthony J. Capobianco, Yashi Ahmed, Ethan Lee, David J. Robbins
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Cereblon (CRBN) is an E3 ubiquitin ligase substrate receptor that is involved in cancer cell death, although its regulation is poorly understood. Here, the authors show that Wnt ligand increases CRBN-dependent protein degradation and demonstrate CRBN
Externí odkaz:
https://doaj.org/article/b0213d02bb5e42d487d2f5912805e034
Autor:
Sidharth Jain, Samantha Rego, Steven Park, Yiran Liu, Simone Parn, Kush Savsani, David S. Perlin, Sivanesan Dakshanamurthy
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 11, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/f6e9f19aee894a85827766a210d7f530
Autor:
Sarita Limbu, Sivanesan Dakshanamurthy
Publikováno v:
Toxics, Vol 11, Iss 7, p 605 (2023)
This study addresses the challenge of assessing the carcinogenic potential of hazardous chemical mixtures, such as per- and polyfluorinated substances (PFASs), which are known to contribute significantly to cancer development. Here, we propose a nove
Externí odkaz:
https://doaj.org/article/667881af9eb0410698eacd79d89eff02
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 932 (2023)
Acute myeloid leukemia (AML) is a leading blood cancer subtype that can be caused by 27 gene mutations. Previous studies have explored potential vaccine and drug treatments against AML, but many were proven immunologically insignificant. Here, we tar
Externí odkaz:
https://doaj.org/article/37f8b8728a37423692a196adb19a50d5
Autor:
Naiem T. Issa, Henri Wathieu, Eric Glasgow, Ivana Peran, Erika Parasido, Tianqi Li, Cynthia M. Simbulan-Rosenthal, Dean Rosenthal, Alexander V. Medvedev, Sergei S. Makarov, Christopher Albanese, Stephen W. Byers, Sivanesan Dakshanamurthy
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 233, Iss , Pp 113330- (2022)
Environmental chemical (EC) exposures and our interactions with them has significantly increased in the recent decades. Toxicity associated biological characterization of these chemicals is challenging and inefficient, even with available high-throug
Externí odkaz:
https://doaj.org/article/26448e49f228463b8b6d816dcd967f02
Publikováno v:
Toxics, Vol 10, Iss 11, p 706 (2022)
Humans are exposed to thousands of chemicals, including environmental chemicals. Unfortunately, little is known about their potential toxicity, as determining the toxicity remains challenging due to the substantial resources required to assess a chem
Externí odkaz:
https://doaj.org/article/4030a3a0d2f644f995c15e05eb5c2e33