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The 18 kDa Mitochondrial Translocator Protein (TSPO) Prevents Accumulation of Protoporphyrin IX. Involvement of Reactive Oxygen Species (ROS)

Autor: Yeshayahu Katz, Menashe Zaaroor, Sivan Zeno, Leo Veenman, Moshe Gavish, Julia Bode

Publikováno v: Current Molecular Medicine. 12:494-501

By exposing cells of the U118MG glioblastoma cell line to protoporphyrin IX (PPIX) in culture, we found that the 18 kDa mitochondrial translocator protein (TSPO) prevents intracellular accumulation of PPIX. In particular, TSPO knockdown by stable tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fbbdf8e5ac36d507784b6deba8f8810
https://doi.org/10.2174/1566524011207040494

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Oral cancer, cigarette smoke and mitochondrial 18kDa translocator protein (TSPO) — In vitro, in vivo, salivary analysis

Autor: Ofer Ben-Izhak, Leo Veenman, Moshe Gavish, Rafael M. Nagler, Sivan Zeno, Dana Savulescu, Ella Krayzler, Sharon Akrish, Irina Otradnov, Svetlana Leschiner

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1802:454-461

Oral cancer features high rates of mortality and morbidity, and is in dire need for new approaches. In the present study we analyzed 18 kDa translocator protein (TSPO) expression in oral (tongue) cancer tumors by immunohistochemistry. We also assayed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39444688f3389d1097678956d2b7e09
https://doi.org/10.1016/j.bbadis.2010.01.008

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Potential involvement of F0F1-ATP(synth)ase and reactive oxygen species in apoptosis induction by the antineoplastic agent erucylphosphohomocholine in glioblastoma cell lines

Autor: Wilfried Kugler, Yulia Shandalov, Sivan Zeno, Moshe Gavish, Karen Linnemannstöns, Julia von Alten, Leo Veenman, Max Lakomek

Publikováno v: Apoptosis. 15:753-768

Erucylphosphohomocholine (ErPC3, Erufosine™) was reported previously to induce apoptosis in otherwise highly apoptosis-resistant malignant glioma cell lines while sparing their non-tumorigenic counterparts. We also previously found that the mitocho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55ffb5d11daff670ca6f3e4b193ffd71
https://doi.org/10.1007/s10495-010-0460-5

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CoCl2Induces Apoptosis via the 18 kDa Translocator Protein in U118MG Human Glioblastoma Cells

Autor: Svetlana Leschiner, Leo Veenman, Sivan Zeno, Moshe Gavish, Menashe Zaaroor

Publikováno v: Biochemistry. 48:4652-4661

The 18 kDa translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor, has been reported to be closely associated with the mitochondrial permeability transition pore (MPTP). TSPO is believed to exert pro-apoptotic func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbaa0734dcacd6349a1f25ae54ffb511
https://doi.org/10.1021/bi900064t

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Effects of 18-kDa translocator protein knockdown on gene expression of glutamate receptors, transporters, and metabolism, and on cell viability affected by glutamate

Autor: Silke Kietz, Julia Bode, Michal Gaitner, Beatriz Caballero, Wilfried Kugler, Yelena Peʼer, Max Lakomek, Sivan Zeno, Moshe Gavish, Leo Veenman

Publikováno v: Pharmacogenetics and genomics. 22(8)

Objective Previously, several important roles for glutamate have been described for the biology of primary brain tumors. For example, glutamate has been suggested to promote glioma cell proliferation by the activation of the 2-amino-3-(5-methyl-3-oxo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f381abde16d4aca88dac494917bbce93
https://pubmed.ncbi.nlm.nih.gov/22732722

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