Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Sivan M. Bokobza"'
Autor:
Rekha Wadekar, Yanyan Jiang, Anderson J. Ryan, Anika M. Weber, Aoife M. Devery, Sivan M. Bokobza
Publikováno v:
International Journal of Oncology
Vascular endothelial growth factor (VEGF) is a key stimulator of physiological and pathological angiogenesis. VEGF signals primarily through VEGF receptor 2 (VEGFR2), a receptor tyrosine kinase whose expression is found predominantly on endothelial c
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 88:947-954
Purpose To evaluate the combination of radiation and an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) in preclinical models of human non-small cell lung cancer. Methods and Materials Sensitivity to an EGFR TKI (gefitinib) or
Autor:
Sivan M. Bokobza, Jinfeng Chen, Robert E. Mansel, Muhammad Moazzam, Jin Li, Lin Ye, Wen Jiang
Publikováno v:
Cancer Science. 101:2137-2144
Our recent study showed that a novel member of bone morphogenetic protein (BMP) family, BMP-10, was decreased in prostate cancer. In the present study, we investigated the implication of BMP-10 in breast cancer, particularly the relation of its expre
Publikováno v:
Journal of Cellular Physiology. 225:529-536
Bone morphogenetic proteins (BMPs) have long been implicated in the process of prostate cancer progression and bone metastasis. This current study investigates the role of GDF-9, a BMP member, in prostate cancer. GDF-9 was over-expressed in PC-3 cell
Publikováno v:
Oncotarget
Although non-small cell lung cancer (NSCLC) patients with EGFR mutation positive (EGFR M+) tumors initially respond well to EGFR tyrosine kinase inhibitor (TKI) monotherapy, the responses are usually incomplete. In this study we show that AKT inhibit
Publikováno v:
Electric Cell-Substrate Impedance Sensing and Cancer Metastasis ISBN: 9789400749269
Bone metastasis is the most common type of metastasis from the three leading cancers, i.e. prostate, breast and lung cancer. Over the last few decades, intensive studies have been carried out to understand and treat the bone metastasis. To date, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fba80dc837bbcbfafca694c5c0371b51
https://doi.org/10.1007/978-94-007-4927-6_13
https://doi.org/10.1007/978-94-007-4927-6_13
Autor:
Luiza Madia Lourenco, Fiona Cahill, Sivan M. Bokobza, Yanyan Jiang, Anika M. Weber, Nuramalina H. Mumin, Thomas M. Ashton, Aoife M. Devery, Anderson J. Ryan, Neele Drobnitzky
Publikováno v:
Molecular Cancer Therapeutics. 14:C114-C114
Lung cancer is the leading cause of cancer related death worldwide and adenocarcinoma is the most prevalent subtype. LKB1 (STK11) is the second most commonly altered tumour suppressor in adenocarcinoma and is inactivated in 17% of samples (1). LKB1 i
Autor:
Anderson J. Ryan, Sivan M. Bokobza, Fiona Cahill, Luiza Madia Lourenco, Neele Drobnitzky, Yanyan Jiang, Aoife Vaughan, Anthony Kong, Anika M. Weber, Nuramalina H. Mumin
Publikováno v:
Molecular Cancer Therapeutics. 14:B88-B88
Background: Triple negative breast cancer (TNBC), which accounts for 10-17% of all breast cancers, is challenging to treat due to its heterogeneity and the absence of identified targeted therapies. Heat shock protein 90 kDa (Hsp90) is a molecular cha
Publikováno v:
Oncology Reports. 24
The majority of advanced prostate cancers metastasise to the bone. Mediators of bone remodelling, the bone morphogenetic proteins have extensively been implicated in the progression and metastasis of prostate cancer. The present study investigated th
Publikováno v:
Molecular and cellular biochemistry. 349(1-2)
The role of bone morphogenetic proteins in the progression and metastasis of prostate cancer is a topic that has undergone extensive research. This study investigates the role of BMP member growth and differentiation factor 9 (GDF-9) in the progressi