Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Sivan Harel"'
Autor:
Matthew P. Kosloski, Emma Guttman‐Yassky, Michael J. Cork, Margitta Worm, Dong‐Ho Nahm, Xiaoping Zhu, Marcella K. Ruddy, Sivan Harel, Mohamed A. Kamal, Hélène Goulaouic, Christine R. Xu, Elena Avetisova, John D. Davis, Michael C. Nivens, Arsalan Shabbir, Allen Radin
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 8, Pp n/a-n/a (2024)
Abstract Interleukin‐33 (IL‐33) is a proinflammatory alarmin cytokine released by damaged epithelial tissue cells that initiates and amplifies both type 1 and type 2 inflammatory cascades. A role for IL‐33 in atopic dermatitis (AD; a chronic, r
Externí odkaz:
https://doaj.org/article/574d478bee6847e5989bba493bdec8fc
Autor:
Matthew P. Kosloski, George D. Kalliolias, Christine R. Xu, Sivan Harel, Ching‐Ha Lai, Wenjun Zheng, John D. Davis, Mohamed A. Kamal
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 2, Pp 384-395 (2022)
Abstract Itepekimab is a monoclonal antibody that targets interleukin (IL‐33) and has been shown to reduce airway inflammation and associated tissue damage in preclinical studies. We assessed the safety, tolerability, pharmacokinetics (PKs), and ph
Externí odkaz:
https://doaj.org/article/feb1920e777547ffb5e5c23f8ef174ce
Autor:
Sivan Harel, Edmund Y Tu, Stuart Weisberg, Manuel Esquilin, Stuart M Chambers, Becky Liu, Christian T Carson, Lorenz Studer, Boris Reizis, Mark J Tomishima
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42302 (2012)
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) offer great promise in regenerative medicine and disease modeling due to their unlimited self-renewal and broad differentiation capacity. There is evidence that the growth propert
Externí odkaz:
https://doaj.org/article/392618b4656a4f26bb7abe9144d80fa9
Autor:
John D. Davis, Mohamed A. Kamal, Sivan Harel, Ching-Ha Lai, Matthew P. Kosloski, Christine Xu, Wenjun Zheng, George D Kalliolias
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 2, Pp 384-395 (2022)
Itepekimab is a monoclonal antibody that targets interleukin (IL‐33) and has been shown to reduce airway inflammation and associated tissue damage in preclinical studies. We assessed the safety, tolerability, pharmacokinetics (PKs), and pharmacodyn
Autor:
Sally E. Wenzel, Ian D. Pavord, Neil M.H. Graham, Megan S. Rice, Thomas G. O'Riordan, Naimish Patel, Paul Rowe, Sivan Harel, Yamo Deniz, J. Mark FitzGerald, Nadia Daizadeh, William W. Busse, Thomas B. Casale
Publikováno v:
The Lancet Respiratory Medicine. 9:1165-1173
Fractional exhaled nitric oxide (FeNO) has potential as a prognostic biomarker in asthma, but its prognostic value among other recognised indicators is unclear. We assessed the added prognostic value of baseline FeNO to blood eosinophil count and pri
Autor:
Ian D, Pavord, Yamo, Deniz, Jonathan, Corren, Thomas B, Casale, J Mark, FitzGerald, Kenji, Izuhara, Nadia, Daizadeh, Benjamin, Ortiz, Robert R, Johnson, Sivan, Harel, Michel, Djandji, Ledia, Goga, Nora, Crikelair, Paul J, Rowe, William W, Busse
Publikováno v:
The Journal of Allergy and Clinical Immunology: In Practice. 11:1213-1220.e2
Fractional exhaled nitric oxide (FeNO) may have a role both as a prognostic and predictive biomarker, in combination with eosinophils, for assessing responsiveness to some biological therapies.We evaluated the value of baseline FeNO, adjusted for bas
Autor:
Mario Castro, Ariel Teper, Siddhesh Kamat, Sivan Harel, Marcella Ruddy, Thomas G. O'Riordan, Jaman Maroni, Nicola A. Hanania, Paul Rowe, Bradley E. Chipps, Megan S. Rice, Alexandre Jagerschmidt, Yufang Lu, Nikhil Amin, Ian D. Pavord, Santiago Quirce, Asif Khan, Karthinathan Thangavelu, Sally E. Wenzel, Jonathan Corren, Neil M.H. Graham, Gianluca Pirozzi
Publikováno v:
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
BACKGROUND: Dupilumab blocks the shared receptor component for IL-4 and IL-13, key drivers of type 2 inflammation, including IgE-mediated allergic inflammation in asthma. In the LIBERTY ASTHMA QUEST (NCT02414854) study, dupilumab reduced severe asthm
Autor:
Claus Bachert, Jonathan Corren, Stella E. Lee, Haixin Zhang, Sivan Harel, Danen Cunoosamy, Asif H. Khan, Juby A. Jacob‐Nara, Shahid Siddiqui, Scott Nash, Paul J. Rowe, Yamo Deniz
Publikováno v:
International forum of allergyrhinology. 12(9)
Autor:
Naimish Patel, Jennifer D. Hamilton, Marius Ardeleanu, Brian N. Swanson, Gianluca Pirozzi, Nikhil Amin, Zhen Chen, William Brian, Allen Radin, Brad Shumel, Sivan Harel, Marcella Ruddy, Megan S. Rice, Leda Mannent, Neil M.H. Graham
Publikováno v:
Clinical and Experimental Allergy
Background Type 2 inflammation is common in numerous atopic/allergic diseases and can be identified by elevated biomarker levels. Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component for interleukin‐4 and interleukin
Autor:
Marc Rothenberg, Ikuo Hirano, Evan Dellon, Margaret Collins, John Leung, Christoph Schlag, Alain Schoepfer, Qiong Zhao, Jennifer Maloney, Sivan Harel, Kiran Patel, Brad Shumel, Angela Khodzhayev, Ledia Goga, Juby Jacob-Nara, Yamo Deniz, Paul Rowe, Elizabeth Laws, Bola Akinlade, Leda Mannent, Nikhil Amin, Danen Cunoosamy, Jennifer Hamilton
Publikováno v:
Journal of Allergy and Clinical Immunology. 149:AB210