Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Sivan, Subburaju"'
Autor:
Gordana D. Vitaliano, Jae K. Kim, Marc J. Kaufman, Christopher W. Adam, Gonzalo Zeballos, Abinaya Shanmugavadivu, Sivan Subburaju, Jay P. McLaughlin, Scott E. Lukas, Franco Vitaliano
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Vitaliano et al. show in mice that engineered clathrin triskelia (CT) conjugated to BDNF (BDNF-CT) and delivered intranasally increases hippocampal BDNF concentrations 400-fold above that achieved previously with intranasal BDNF alone. They also show
Externí odkaz:
https://doaj.org/article/b5730de6c08e4529a733ee1ca929bea8
Autor:
Anass Agrud, Sivan Subburaju, Pranay Goel, Jun Ren, Ashwin Srinivasan Kumar, Barbara J. Caldarone, Wangde Dai, Jesus Chavez, Dai Fukumura, Rakesh K. Jain, Robert A. Kloner, Anju Vasudevan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Our recent studies uncovered a novel GABA signaling pathway in embryonic forebrain endothelial cells that works independently from neuronal GABA signaling and revealed that disruptions in endothelial GABAA receptor-GABA signaling from early
Externí odkaz:
https://doaj.org/article/a0dbbdf66bb540ea9f25495ef048a18d
Autor:
Jugajyoti Baruah, Yong Kee Choi, Sivan Subburaju, Abdallah Elkhal, Sarah Kaye, Sangmi Chung, Yeqi Nian, Jahan Khalili, Debkanya Datta, Anju Vasudevan
Publikováno v:
Molecular Psychiatry
Abnormalities of or reductions in GABAergic interneurons are implicated in the pathology of severe neuropsychiatric disorders, for which effective treatments are still elusive. Transplantation of human stem cell-derived interneurons is a promising ce
Publikováno v:
ACS Chem Neurosci
The dopamine D(2) receptor exists in two different states, D(2)(high) and D(2low); the former is the functional form of the D(2) receptor and associates with intracellular G-proteins. The D(2) agonist [(3)H]MCL-536 has high affinity for the D(2) rece
Variability of DNA Methylation within Schizophrenia Risk Loci across Subregions of Human Hippocampus
Publikováno v:
Genes, Vol 8, Iss 5, p 143 (2017)
Identification of 108 genomic regions significantly associated with schizophrenia risk by the Psychiatric Genomics Consortium was a milestone for the field, and much work is now focused on determining the mechanism of risk associated with each locus.
Externí odkaz:
https://doaj.org/article/cbaac6db1a3f4bc0b00cd6dbd765ad7e
Autor:
Shahin Mohammadi, Jose Davila-Velderrain, Makayla Hourihan, Sivan Subburaju, Daniel Reed Tso, Manolis Kellis, W. Brad Ruzicka
Schizophrenia is a devastating mental disorder with a high societal burden, complex pathophysiology, and diverse genetic and environmental risk factors. Its complexity, polygenicity, and small-effect-size and cell-type-specific contributors have hind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c86d75be54e247d94f6ba7b2f9040db
https://doi.org/10.1101/2020.11.06.20225342
https://doi.org/10.1101/2020.11.06.20225342
Autor:
Gordana D, Vitaliano, Jae K, Kim, Marc J, Kaufman, Christopher W, Adam, Gonzalo, Zeballos, Abinaya, Shanmugavadivu, Sivan, Subburaju, Jay P, McLaughlin, Scott E, Lukas, Franco, Vitaliano
Publikováno v:
Communications biology. 5(1)
Brain derived neurotrophic factor (BDNF) promotes the growth, differentiation, maintenance and survival of neurons. These attributes make BDNF a potentially powerful therapeutic agent. However, its charge, instability in blood, and poor blood brain b
Autor:
Dai Fukumura, Jugajyoti Baruah, Jun Ren, Ashwin S. Kumar, Anju Vasudevan, Yong Kee Choi, Rakesh K. Jain, Gábor Szabó, Debkanya Datta, Abdallah Elkhal, Sivan Subburaju, Sarah Kaye
Publikováno v:
Science Advances. 6
Intrinsic defects within blood vessels from the earliest developmental time points can directly contribute to psychiatric disease origin. Here, we show that nicotinamide adenine dinucleotide (NAD+), administered during a critical window of prenatal d
Autor:
Sivan, Subburaju, Sarah, Kaye, Yong Kee, Choi, Jugajyoti, Baruah, Debkanya, Datta, Jun, Ren, Ashwin Srinivasan, Kumar, Gabor, Szabo, Dai, Fukumura, Rakesh K, Jain, Abdallah, Elkhal, Anju, Vasudevan
Publikováno v:
Science Advances
Prenatal NAD+ treatment can rescue abnormal brain development and prevent the origin of mental illness.
Intrinsic defects within blood vessels from the earliest developmental time points can directly contribute to psychiatric disease origin. Her
Intrinsic defects within blood vessels from the earliest developmental time points can directly contribute to psychiatric disease origin. Her
Autor:
Sivan Subburaju, Francine M Benes
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33352 (2012)
Recent studies of the hippocampus have suggested that a network of genes is associated with the regulation of the GAD₆₇ (GAD1) expression and may play a role in γ-amino butyric acid (GABA) dysfunction in schizophrenia (SZ) and bipolar disorder (
Externí odkaz:
https://doaj.org/article/b974aadf32524ae996df9491481857ee