Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sivalokanathan Sarveswaran"'
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122805 (2015)
Castration-resistant prostate cancer (CRPC) is a major clinical challenge for which no cure is currently available primarily because of the lack of proper understanding about appropriate molecular target(s). Previously we observed that inhibition of
Externí odkaz:
https://doaj.org/article/96cb1b35b00841eab950142097751488
Supplementary Figure 1-chemical structures of Wedelolactone and Enzalutamide.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49dd3cce49194ec28a1c86ca173ced6f
https://doi.org/10.1158/1535-7163.22506015
https://doi.org/10.1158/1535-7163.22506015
Publikováno v:
Oncotarget
The cancer stem cell (CSC) concept suggests that neoplastic clones are maintained exclusively by a rare group of cells possessed with stem cell properties. CSCs are characterized by features that include self-renewal, pluripotency and tumorigenicity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d09e33ffe636e1173615e7721a17a1
https://doi.org/10.18632/oncotarget.13422
https://doi.org/10.18632/oncotarget.13422
The c-Myc gene encodes an oncoprotein transcription factor that is frequently upregulated in almost all cancer types and is the subject of intense investigation for management of cancer because of its pleiotropic effects controlling a spectrum of cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8213d750d817c22b2423c57016064c9
https://europepmc.org/articles/PMC5096967/
https://europepmc.org/articles/PMC5096967/
Publikováno v:
Cancer Letters. 291:167-176
MK591 is a synthetic compound which specifically inhibits the activity of 5-Lox and is currently under development for the treatment of asthma. We observed that human prostate cancer cells treated with MK591 undergo apoptosis within hours of treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad0fb022c7e6424a437eef98b886c74
https://doi.org/10.1016/j.canlet.2009.10.008
https://doi.org/10.1016/j.canlet.2009.10.008
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122805 (2015)
PLoS ONE
PLoS ONE
Castration-resistant prostate cancer (CRPC) is a major clinical challenge for which no cure is currently available primarily because of the lack of proper understanding about appropriate molecular target(s). Previously we observed that inhibition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3e50e76cdbd5767cb4bff5ec21c34a
http://europepmc.org/articles/PMC4398363?pdf=render
http://europepmc.org/articles/PMC4398363?pdf=render
Autor:
Rosalie C. Sears, Dhananjay Chitale, Jagadananda Ghosh, Sivalokanathan Sarveswaran, Debrup Chakraborty
Myc is up-regulated in almost all cancer types and is the subject of intense investigation because of its pleiotropic effects controlling a broad spectrum of cell functions. However, despite its recognition as a stand-alone molecular target, developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3e69986659bc6de1acaa8292618b7d
https://europepmc.org/articles/PMC4335236/
https://europepmc.org/articles/PMC4335236/
Publikováno v:
International Journal of Oncology
Emerging studies indicate that metabolism of arachidonic acid through the 5-lipoxygenase (5-Lox) pathway plays a critical role in the survival of prostate cancer cells raising the possibility that 5-Lox can be targeted for an effective therapy of pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039c3f026c69280db7f75dd9eef77673
https://pubmed.ncbi.nlm.nih.gov/23076676
https://pubmed.ncbi.nlm.nih.gov/23076676
Autor:
Zongxiang Zhou, Joshua Liroff, Alexander Yu. Nikitin, Jagadananda Ghosh, Sivalokanathan Sarveswaran
Publikováno v:
International Journal of Oncology. 36
Supra-nutritional selenium supplementation has emerged as an attractive new approach to intervene in a range of human cancers, in particular prostate cancer. However, scanty information is currently available on molecular mechanisms underlying seleni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f5c87de1edbd9b1f3211ef3e382d8b
https://doi.org/10.3892/ijo_00000627
https://doi.org/10.3892/ijo_00000627
Publikováno v:
Cancer Research. 74:2702-2702
Background: Prostate cancer cells continuously generate 5(S)-HETE series of metabolites from arachidonic acid via 5-lipoxygenase (5-Lox) activity, and inhibition of 5-Lox blocks production of metabolites and triggers apoptosis both in androgen-sensit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::768eae8a49c182dd4c8e7c30462ce31f
https://doi.org/10.1158/1538-7445.am2014-2702
https://doi.org/10.1158/1538-7445.am2014-2702