Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sivakumar Vadivel Gnanasundram"'
Autor:
Ondrej Bonczek, Lixiao Wang, Sivakumar Vadivel Gnanasundram, Sa Chen, Lucia Haronikova, Filip Zavadil-Kokas, Borivoj Vojtesek
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9329 (2022)
DNA and RNA binding proteins (DRBPs) are a broad class of molecules that regulate numerous cellular processes across all living organisms, creating intricate dynamic multilevel networks to control nucleotide metabolism and gene expression. These inte
Externí odkaz:
https://doaj.org/article/f18246cbe08741fd9f7924c8e8c7f402
Autor:
Sivakumar Vadivel Gnanasundram, Slovénie Pyndiah, Chrysoula Daskalogianni, Kate Armfield, Karin Nylander, Joanna B. Wilson, Robin Fåhraeus
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The oncogenic activity of EBNA1 protein is unknown; it contains a glycine and alanine repeat sequence (GAr) which regulates its own translation in cis. Here the authors show that GAr stimulates PI3Kδ-mediated induction of E2F1 translation, leading t
Externí odkaz:
https://doaj.org/article/869477af35b34d6ba3566d32e1799f29
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 12, p 3757 (2018)
Ribosome and protein synthesis are major metabolic events that control cellular growth and proliferation. Impairment in ribosome biogenesis pathways and mRNA translation is associated with pathologies such as cancer and developmental disorders. Proce
Externí odkaz:
https://doaj.org/article/2dc41f87045f446ca183c13d165aaa6f
Autor:
Leila Fusée, Norman Salomao, Anand Ponnuswamy, Lixiao Wang, Ignacio López, Sa Chen, Xiaolian Gu, Stavros Polyzoidis, Sivakumar Vadivel Gnanasundram, Robin Fahraeus
Publikováno v:
Cell Death & Differentiation. 30:1072-1081
Cellular stress conditions activate p53-dependent pathways to counteract the inflicted damage. To achieve the required functional diversity, p53 is subjected to numerous post-translational modifications and the expression of isoforms. Little is yet k
Autor:
Xiaolian Gu, Lixiao Wang, Philip J Coates, Sivakumar Vadivel Gnanasundram, Nicola Sgaramella, Jonas Sörlin, Baris Erdogan, Mustafa Magan, Karin Nylander
Publikováno v:
The Journal of Pathology. 259:93-102
Oral cancer is a paradigm of Slaughter's concept of field cancerization, where tumors are thought to originate within an area of cells containing genetic alterations that predispose to cancer development. The field size is unclear but may represent a
Publikováno v:
Nucleic Acids Research
The RNA helicase Has1 is involved in the biogenesis of both small and large ribosomal subunits. How it performs these separate roles is not fully understood. Here we provide evidence that at least two molecules of Has1 are temporarily present at the
Publikováno v:
Genes, Vol 12, Iss 1446, p 1446 (2021)
Genes
Genes
Human cells are subjected to continuous challenges by different genotoxic stress attacks. DNA damage leads to erroneous mutations, which can alter the function of oncogenes or tumor suppressors, resulting in cancer development. To circumvent this, ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40012d6fc0e578bb213ec0b6b9900c9e
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-188154
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-188154
Autor:
Sa Chen, Laurence Malbert-Colas, Chrysoula Daskalogianni, Petr Müller, Robin Fåhraeus, Leïla T. S. Fusée, Norman Salomao, Sivakumar Vadivel Gnanasundram
Publikováno v:
Nucleic Acids Research
Cell growth requires a high level of protein synthesis and oncogenic pathways stimulate cell proliferation and ribosome biogenesis. Less is known about how cells respond to dysfunctional mRNA translation and how this feeds back into growth regulatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5028d9524df323b56f3d504d70a8c10
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-176089
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-176089
Autor:
Robin Fåhraeus, Slovenie Pyndiah, Chrysoula Daskalogianni, Karin Nylander, Joanna B. Wilson, Sivakumar Vadivel Gnanasundram, Kate Armfield
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications
Nature Communications
The c-myc oncogene stimulates ribosomal biogenesis and protein synthesis to promote cellular growth. However, the pathway by which cells sense and restore dysfunctional mRNA translation and how this is linked to cell proliferation and growth is not k
The RNA helicase Has1 is involved in the biogenesis of both small and large ribosomal subunits. How it performs these separate roles is not fully understood. Here we provide evidence that two molecules of Has1 are recruited and temporarily present in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d362f4195b4b48f48e829ff7dc68e2