Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Sivakumar, Periasamy"'
Autor:
Shixia Wang, Chang Yi Wang, Hui-Kai Kuo, Wen-Jiun Peng, Juin-Hua Huang, Be-Shen Kuo, Feng Lin, Yaw-Jen Liu, Zhi Liu, Huang-Ting Wu, Shuang Ding, Kou-Liang Hou, Jennifer Cheng, Ya-Ting Yang, Ming-Han Jiang, Min-Sheng Wang, Tony Chen, Wei Guo Xia, Ed Lin, Chung Ho Hung, Hui-Jung Chen, Zhonghao Shih, Yi Ling Lin, Valorie Ryan, Mei Mei Hu, D. Gray Heppner, Delphine C. Malherbe, Sivakumar Periasamy, Natalia Kuzmina, Chandru Subramani, Michael Hellerstein, Thomas P. Monath, Alexander Rumyantsev, Alexander Bukreyev, Farshad Guirakhoo
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 2724-2734 (2022)
The development of safe and effective vaccines to respond to COVID-19 pandemic/endemic remains a priority. We developed a novel subunit protein-peptide COVID-19 vaccine candidate (UB-612) composed of: (i) receptor binding domain of SARS-CoV-2 spike p
Externí odkaz:
https://doaj.org/article/d9e5af23b5ef47048009e734003b47bf
Autor:
Yang Liu, Xianwen Zhang, Jianying Liu, Hongjie Xia, Jing Zou, Antonio E. Muruato, Sivakumar Periasamy, Chaitanya Kurhade, Jessica A. Plante, Nathen E. Bopp, Birte Kalveram, Alexander Bukreyev, Ping Ren, Tian Wang, Vineet D. Menachery, Kenneth S. Plante, Xuping Xie, Scott C. Weaver, Pei-Yong Shi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
A live-attenuated COVID vaccine could enrich the current vaccine portfolio. Here, Liu et al. engineer a live-attenuated SARS-CoV-2 vaccine candidate by deleting four viral accessory genes and show immunogenicity and protection in mice and hamsters.
Externí odkaz:
https://doaj.org/article/cc13b11bea644900bb74ddc607f241fd
Autor:
Philipp A. Ilinykh, Sivakumar Periasamy, Kai Huang, Natalia A. Kuzmina, Palaniappan Ramanathan, Michelle N. Meyer, Chad E. Mire, Ivan V. Kuzmin, Preeti Bharaj, Jessica R. Endsley, Maria Chikina, Stuart C. Sealfon, Steven G. Widen, Mark A. Endsley, Alexander Bukreyev
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-16 (2022)
Abstract Respiratory tract vaccination has an advantage of needle-free delivery and induction of mucosal immune response in the portal of SARS-CoV-2 entry. We utilized human parainfluenza virus type 3 vector to generate constructs expressing the full
Externí odkaz:
https://doaj.org/article/f7f896e4aff94be8a7c13063d10aa8bd
Autor:
Shixia Wang, Farshad Guirakhoo, Sivakumar Periasamy, Valorie Ryan, Jonathan Wiggins, Chandru Subramani, Brett Thibodeaux, Jaya Sahni, Michael Hellerstein, Natalia A. Kuzmina, Alexander Bukreyev, Jean-Cosme Dodart, Alexander Rumyantsev
Publikováno v:
Vaccines, Vol 12, Iss 1, p 40 (2023)
Antibodies provide critical protective immunity against COVID-19, and the Fc-mediated effector functions and mucosal antibodies also contribute to the protection. To expand the characterization of humoral immunity stimulated by subunit protein–pept
Externí odkaz:
https://doaj.org/article/3bd90e0903d2463bbdf1e486c081e889
Autor:
Sindhu Vangeti, Sivakumar Periasamy, Peifang Sun, Corey A. Balinsky, Avinash S. Mahajan, Natalia A. Kuzmina, Alessandra Soares-Schanoski, Elizabeth Cooper, Charmagne Beckett, Jan Marayag, Amethyst Marrone, Edgar Nunez, Yongchao Ge, Chad K. Porter, Carl W. Goforth, Stephen E. Lizewski, Rhonda Lizewski, Vihasi Jani, Victor A. Sugiharto, Megan Schilling, Xuechen B. Yu, Nada Marjanovic, Mary Catherine George, Alexander Bukreyev, Stuart C. Sealfon, Andrew G. Letizia, Irene Ramos
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT We investigated the temporal profile of multiple components of the serological response after asymptomatic or mildly symptomatic SARS-CoV-2 infection, in a cohort of 67 previously SARS-CoV-2 naive young adults, up to 8.5 months after infecti
Externí odkaz:
https://doaj.org/article/289d08297fff42ee91c25c4674537c69
Autor:
Delphine C. Malherbe, Drishya Kurup, Christoph Wirblich, Adam J. Ronk, Chad Mire, Natalia Kuzmina, Noor Shaik, Sivakumar Periasamy, Matthew A. Hyde, Julie M. Williams, Pei-Yong Shi, Matthias J. Schnell, Alexander Bukreyev
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
Abstract The development of effective countermeasures against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for the COVID-19 pandemic, is a priority. We designed and produced ConVac, a replication-competent vesic
Externí odkaz:
https://doaj.org/article/ebf985f490e445e383c6a2b50cb40eb9
Autor:
Alessandra Soares-Schanoski, Natalie Sauerwald, Carl W. Goforth, Sivakumar Periasamy, Dawn L. Weir, Stephen Lizewski, Rhonda Lizewski, Yongchao Ge, Natalia A. Kuzmina, Venugopalan D. Nair, Sindhu Vangeti, Nada Marjanovic, Antonio Cappuccio, Wan Sze Cheng, Sagie Mofsowitz, Clare M. Miller, Xuechen B. Yu, Mary-Catherine George, Elena Zaslavsky, Alexander Bukreyev, Olga G. Troyanskaya, Stuart C. Sealfon, Andrew G. Letizia, Irene Ramos
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Young adults infected with SARS-CoV-2 are frequently asymptomatic or develop only mild disease. Because capturing representative mild and asymptomatic cases require active surveillance, they are less characterized than moderate or severe cases of COV
Externí odkaz:
https://doaj.org/article/707fabbf40d848cca1029db10b1e25b6
Autor:
Kevin J. Kramer, Nicole V. Johnson, Andrea R. Shiakolas, Naveenchandra Suryadevara, Sivakumar Periasamy, Nagarajan Raju, Jazmean K. Williams, Daniel Wrapp, Seth J. Zost, Lauren M. Walker, Steven C. Wall, Clinton M. Holt, Ching-Lin Hsieh, Rachel E. Sutton, Ariana Paulo, Rachel S. Nargi, Edgar Davidson, Benjamin J. Doranz, James E. Crowe, Jr., Alexander Bukreyev, Robert H. Carnahan, Jason S. McLellan, Ivelin S. Georgiev
Publikováno v:
Cell Reports, Vol 37, Iss 1, Pp 109784- (2021)
Summary: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages that are more transmissible and resistant to currently approved antibody therapies poses a considerable challenge to the clinical treatment of coronavirus
Externí odkaz:
https://doaj.org/article/f0d8cdf7656645d0b29756b1b1c69e65
Autor:
Yang Liu, Xianwen Zhang, Jianying Liu, Hongjie Xia, Jing Zou, Antonio E. Muruato, Sivakumar Periasamy, Chaitanya Kurhade, Jessica A. Plante, Nathen E. Bopp, Birte Kalveram, Alexander Bukreyev, Ping Ren, Tian Wang, Vineet D. Menachery, Kenneth S. Plante, Xuping Xie, Scott C. Weaver, Pei-Yong Shi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/064ecce2749f459593efdf62597fd697
Autor:
Sivakumar Periasamy, Kristen A. Porter, Maninjay K. Atianand, Hongnga T. Le, Sarah Earley, Ellen B. Duffy, Matthew C. Haller, Heather Chin, Jonathan A. Harton
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Pyrin-only proteins (POPs) are primate-specific negative regulators of inflammasome activation. Here the authors generate transgenic mice expressing POP2 under the control of the human promoter, and show that POP2 is important for balancing antibacte
Externí odkaz:
https://doaj.org/article/0563f30dbd054df89affef0a6ff7f607