Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Siva Rama Raju Kanumuri"'
Autor:
Erin C. Berthold, Shyam H. Kamble, Siva Rama Raju Kanumuri, Michelle A. Kuntz, Alexandria S. Senetra, Yi-Hua Chiang, Sushobhan Mukhopadhyay, Christopher R. McCurdy, Abhisheak Sharma
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 318 (2024)
Kratom and cannabidiol products are used to self-treat a variety of conditions, including anxiety and pain, and to elevate mood. Research into the individual pharmacokinetic properties of commercially available kratom and cannabidiol products has bee
Externí odkaz:
https://doaj.org/article/1896d11b881d4b36b3b8b9220d43cfab
Autor:
David A. Ostrov, Andrew P. Bluhm, Danmeng Li, Juveriya Qamar Khan, Megha Rohamare, Karthic Rajamanickam, Kalpana K. Bhanumathy, Jocelyne Lew, Darryl Falzarano, Franco J. Vizeacoumar, Joyce A. Wilson, Marco Mottinelli, Siva Rama Raju Kanumuri, Abhisheak Sharma, Christopher R. McCurdy, Michael H. Norris
Publikováno v:
Pathogens, Vol 10, Iss 11, p 1514 (2021)
(1) Background: There is a strong need for prevention and treatment strategies for COVID-19 that are not impacted by SARS-CoV-2 mutations emerging in variants of concern. After virus infection, host ER resident sigma receptors form direct interaction
Externí odkaz:
https://doaj.org/article/63add6fb9ba140d2866daea0ebf129c3
Autor:
Shyam H. Kamble, Samuel Obeng, Francisco León, Luis F. Restrepo, Tamara I. King, Erin C. Berthold, Siva Rama Raju Kanumuri, Lea R. Gamez-Jimenez, Victoria L.C. Pallares, Avi Patel, Nicholas P. Ho, Aidan Hampson, Christopher R. McCurdy, Lance R. McMahon, Jenny L. Wilkerson, Abhisheak Sharma, Takato Hiranita
Publikováno v:
J Pharmacol Exp Ther
Mitragynine, an opioidergic alkaloid present in Mitragyna speciosa (kratom), is metabolized by cytochrome P450 3A (CYP3A) to 7-hydroxymitragynine, a more potent opioid receptor agonist. The extent to which conversion to 7-hydroxymitragynine mediates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9288dd2b6b7ca7f4d59c89456a88b52
https://doi.org/10.1124/jpet.122.001525
https://doi.org/10.1124/jpet.122.001525
Autor:
Larissa C. Laforest, Michelle A. Kuntz, Siva Rama Raju Kanumuri, Sushobhan Mukhopadhyay, Abhisheak Sharma, Sarah E. O’Connor, Christopher R. McCurdy, Satya Swathi Nadakuduti
Publikováno v:
Journal of Natural Products. 86:1042-1052
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4d4428f01b07d8d5f2d5f9e00ead0f6
https://doi.org/10.1021/acs.jnatprod.3c00092
https://doi.org/10.1021/acs.jnatprod.3c00092
Autor:
Shyam H. Kamble, Erin C. Berthold, Siva Rama Raju Kanumuri, Tamara I. King, Michelle A. Kuntz, Francisco León, Marco Mottinelli, Lance R. McMahon, Christopher R. McCurdy, Abhisheak Sharma
Publikováno v:
The AAPS Journal. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccda6d4cc19c400bb1ffe6113bb47dde
https://doi.org/10.1208/s12248-022-00736-8
https://doi.org/10.1208/s12248-022-00736-8
Autor:
Surash Ramanathan, Abhisheak Sharma, Darshan Singh, Lance R. McMahon, Luis F. Restrepo, Takato Hiranita, Avi Patel, Siva Rama Raju Kanumuri, Nelson Jeng Yeou Chear, Francisco León, Grant Zwolinski, Khalil A. Abboud, Christopher R. McCurdy, Aidan J. Hampson
Publikováno v:
Journal of Natural Products. 84:1034-1043
Ten indole and oxindole alkaloids (1-10) were isolated from the freshly collected leaves of Malaysian Mitragyna speciosa (Kratom). The chemical structures of these compounds were established on the basis of extensive 1D and 2D NMR and HRMS data analy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2bd4427dece809193761e8756ae0c3f
https://doi.org/10.1021/acs.jnatprod.0c01055
https://doi.org/10.1021/acs.jnatprod.0c01055
Autor:
Abhisheak Sharma, Joyce A. Wilson, Jocelyne Lew, Franco J. Vizeacoumar, Marco Mottinelli, Christopher R. McCurdy, Michael H. Norris, Danmeng Li, Darryl Falzarano, Megha Rohamare, Karthic Rajamanickam, David A. Ostrov, Andrew P. Bluhm, Kalpana Kalyanasundaram Bhanumathy, Juveriya Q Khan, Siva Rama Raju Kanumuri
Publikováno v:
Pathogens
Volume 10
Issue 11
Pathogens, Vol 10, Iss 1514, p 1514 (2021)
Volume 10
Issue 11
Pathogens, Vol 10, Iss 1514, p 1514 (2021)
(1) Background: There is a strong need for prevention and treatment strategies for COVID-19 that are not impacted by SARS-CoV-2 mutations emerging in variants of concern. After virus infection, host ER resident sigma receptors form direct interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe3a93e191d91e2a0b39ea4d1451a31
Autor:
Siva Rama Raju Kanumuri, Jessica Mamallapalli, Robyn Nelson, Christopher R. McCurdy, Carol A. Mathews, Chengguo Xing, Abhisheak Sharma
Publikováno v:
J Ethnopharmacol
ETHNOPHARMACOLOGICAL RELEVANCE: Piper methysticum G. Forst. (Piperaceae), commonly known as kava, has been used as a traditional beverage for centuries for its relaxing properties. Kavalactones are considered to be the major constituents responsible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18b97fcba99b2926a5af7016c805b48
https://doi.org/10.1016/j.jep.2022.115514
https://doi.org/10.1016/j.jep.2022.115514
Autor:
Nelson Jeng-Yeou, Chear, Francisco, León, Abhisheak, Sharma, Siva Rama Raju, Kanumuri, Grant, Zwolinski, Khalil A, Abboud, Darshan, Singh, Luis F, Restrepo, Avi, Patel, Takato, Hiranita, Surash, Ramanathan, Aidan J, Hampson, Lance R, McMahon, Christopher R, McCurdy
Publikováno v:
J Nat Prod
Ten indole and oxindole alkaloids (1–10) were isolated from the freshly collected leaves of Malaysian Mitragyna speciosa (Kratom). The chemical structures of these compounds were established on the basis of extensive 1D and 2D NMR and HRMS data ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b0601c60011704db7786f1365a5abacb
https://pubmed.ncbi.nlm.nih.gov/33635670
https://pubmed.ncbi.nlm.nih.gov/33635670
Autor:
Siva Rama Raju Kanumuri, Christopher R. McCurdy, Lance R. McMahon, Bonnie A. Avery, Abhisheak Sharma, Julius R Herting, Raluca Popa, Francisco León, Shyam H. Kamble, Tamara I. King, Erin C. Berthold
Publikováno v:
J Nat Prod
Kratom, Mitragyna speciosa Korth., is being widely consumed in the United States for pain management and the reduction of opioid withdrawal symptoms. The central nervous system (CNS) active alkaloids of kratom, including mitragynine, 7-hydroxymitragy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48910787ea4330acf479c95b2ea22a9d
https://pubmed.ncbi.nlm.nih.gov/33620222
https://pubmed.ncbi.nlm.nih.gov/33620222