Výsledky vyhledávání - "Siva Krishna Angalakurthi"

Akademický článek

A Collection of Single-Domain Antibodies that Crowd Ricin Toxin’s Active Site

Autor: Siva Krishna Angalakurthi, David J. Vance, Yinghui Rong, Chi My Thi Nguyen, Michael J. Rudolph, David Volkin, C. Russell Middaugh, David D. Weis, Nicholas J. Mantis

Publikováno v: Antibodies, Vol 7, Iss 4, p 45 (2018)

In this report, we used hydrogen exchange-mass spectrometry (HX-MS) to identify the epitopes recognized by 21 single-domain camelid antibodies (VHHs) directed against the ribosome-inactivating subunit (RTA) of ricin toxin, a biothreat agent of concer

Externí odkaz: https://doaj.org/article/08b529d18940415d831f6223da371ea8

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Investigating the dynamics and polyanion binding sites of fibroblast growth factor-1 using hydrogen-deuterium exchange mass spectrometry

Autor: Siva Krishna Angalakurthi, Connie A. Tenorio, C.R. Middaugh, Michael Blaber

Publikováno v: Protein Science. 27:1068-1082

In this study, we examined the local dynamics of acidic fibroblast growth factor (FGF-1) as well as the binding sites of various polyanions including poly-sulfates (heparin and low MW heparin) and poly-phosphates (phytic acid and ATP) using hydrogen-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30e2765d407d6dace783a0d97c09f957
https://doi.org/10.1002/pro.3423

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Using homology modeling to interrogate binding affinity in neutralization of ricin toxin by a family of single domain antibodies

Autor: Siva Krishna Angalakurthi, Nicholas J. Mantis, Ronald T. Toth, Andrea Bazzoli, C. Russell Middaugh, John Karanicolas, David B. Volkin, David D. Weis, Michael J. Rudolph, Yinghui Rong, David J. Vance

Publikováno v: Proteins: Structure, Function, and Bioinformatics

In this report we investigated, within a group of closely related single domain camelid antibodies (VHHs), the relationship between binding affinity and neutralizing activity as it pertains to ricin, a fast-acting toxin and biothreat agent. The V1C7-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1627644f7f8cf4ba35fbe6f66bd8b9
https://doi.org/10.1002/prot.25353

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Fine-Specificity Epitope Analysis Identifies Contact Points on Ricin Toxin Recognized by Protective Monoclonal Antibodies

Autor: C. Russell Middaugh, Nicholas J. Mantis, Siva Krishna Angalakurthi, Ronald T. Toth, Yuqi Shi, Dylan J. Ehrbar, David J. Vance, Greta Van Slyke, Yinghui Rong, David B. Volkin, David D. Weis

Publikováno v: ImmunoHorizons. 2(8)

Ricin is a fast-acting protein toxin classified by the Centers for Disease Control and Prevention as a biothreat agent. In this report, we describe five new mouse mAbs directed against an immunodominant region, so-called epitope cluster II, on the su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b1f7877da36543e02ba533f319b33c
https://pubmed.ncbi.nlm.nih.gov/30766971

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A Collection of Single-Domain Antibodies that Crowd Ricin Toxin’s Active Site

Autor: David B. Volkin, Siva Krishna Angalakurthi, C. Russell Middaugh, David D. Weis, Chi My Thi Nguyen, Yinghui Rong, Nicholas J. Mantis, Michael J. Rudolph, David J. Vance

Publikováno v: Antibodies
Volume 7
Issue 4
Antibodies, Vol 7, Iss 4, p 45 (2018)
Antibodies (Basel, Switzerland)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09723cf0d5a3e89993d597592ff1c76

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A Lipid Base Formulation for Intramuscular Administration of a Novel Sulfur Donor for Cyanide Antagonism

Autor: Kristof Kovacs, Prashanth Jayanna, Siva Krishna Angalakurthi, Petra Füredi, Gary A. Rockwood, Brittany Winner, Anna Duke, Peter Sipos, Jorn C. C. Yu, Ilona Petrikovics, Krisztina Ludányi, Melaeni Negrito

Publikováno v: Current Drug Delivery. 13:1351-1357

This study represents a new formulation of the novel Cyanide (CN) antidote, Dimethyl trisulfide (DMTS), for intramuscular administration. This is a naturally occurring organosulfur molecule with the capability of reacting with CN more efficiently tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eced53fc849317e635edf85a3e11f013
https://doi.org/10.2174/1567201813666160321115851

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High-Definition Mapping of Four Spatially Distinct Neutralizing Epitope Clusters on RiVax, a Candidate Ricin Toxin Subunit Vaccine

Autor: David D. Weis, Ronald T. Toth, Nicholas J. Mantis, C. Russell Middaugh, John M. Hickey, Sangeeta B. Joshi, David J. Vance, Siva Krishna Angalakurthi, David B. Volkin, Greta Van Slyke

Publikováno v: Clinical and Vaccine Immunology. 24

RiVax is a promising recombinant ricin toxin A subunit (RTA) vaccine antigen that has been shown to be safe and immunogenic in humans and effective at protecting rhesus macaques against lethal-dose aerosolized toxin exposure. We previously used a pan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd7066d8d6a0479a682ee7fd7bc80e2
https://doi.org/10.1128/cvi.00237-17

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High-Resolution Epitope Positioning of a Large Collection of Neutralizing and Nonneutralizing Single-Domain Antibodies on the Enzymatic and Binding Subunits of Ricin Toxin

Autor: David D. Weis, Charles B. Shoemaker, Nicholas J. Mantis, C. Russell Middaugh, Jacqueline M. Tremblay, Siva Krishna Angalakurthi, David J. Vance, Yinghui Rong, David B. Volkin

Publikováno v: Clinical and vaccine immunology : CVI. 24(12)

We previously produced a heavy-chain-only antibody (Ab) VH domain (V H H)-displayed phage library from two alpacas that had been immunized with ricin toxoid and nontoxic mixtures of the enzymatic ricin toxin A subunit (RTA) and binding ricin toxin B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4aa69cac5b8da74d4a64e76ec87c43
https://pubmed.ncbi.nlm.nih.gov/29021300

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Intravascular Residence Time Determination for the Cyanide Antidote Dimethyl Trisulfide in Rat by Using Liquid-Liquid Extraction Coupled with High Performance Liquid Chromatography

Autor: Ilona Petrikovics, Siva Krishna Angalakurthi, Steven B. Lee, David E. Thompson, Anna Duke, Ching-En Chou, Afshin Ebrahimpour, Deepthika De Silva

Publikováno v: Journal of Analytical Methods in Chemistry
Journal of Analytical Methods in Chemistry, Vol 2016 (2016)

These studies represent the first report on the intravascular residence time determinations for the cyanide antidote dimethyl trisulfide (DMTS) in a rat model by using high performance liquid chromatography coupled with ultraviolet absorption spectro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b821980228e493b1192a6b20240b8a
https://pubmed.ncbi.nlm.nih.gov/28053802

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Identification, solubility enhancement and in vivo testing of a cyanide antidote candidate

Autor: Ilona Petrikovics, Senan Rasheed, Assumpta Nwaneri, Madhuri Ancha, Stephen Lee, Mario Jane, Kristof Kovacs, Maelani Negrito, Siva Krishna Angalakurthi

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 49(3)

Present studies focused on the in vitro testing, the solubility enhancement and the in vivo testing of methyl propyl trisulfide (MPTS), a newly identified sulfur donor to treat cyanide (CN) intoxication. To enhance the solubility of the lipophilic MP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d2af7c0eb0391fd26b5acf7991c7b7
https://pubmed.ncbi.nlm.nih.gov/23602996

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