Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Siva Charan Devanaboyina"'
Autor:
Siva Charan Devanaboyina, Peng Li, Edward L. LaGory, Carrie Poon-Andersen, Kevin D. Cook, Marcus Soto, Zhe Wang, Khue Dang, Craig Uyeda, Ryan B. Case, Veena A. Thomas, Ronya Primack, Manuel Ponce, Mei Di, Brian Ouyang, Joelle Kaner, Sheung Kwan Lam, Mina Mostafavi
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Targeting antigens with antibodies exhibiting pH/Ca2+-dependent binding against an antigen is an attractive strategy to mitigate target-mediated disposition and antigen buffering. Studies have reported improved serum exposure of antibodies exhibiting
Externí odkaz:
https://doaj.org/article/e01cdf9351b64b009ab7296a2022f247
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
The depletion of antigen-specific, deleterious antibodies during therapy and diagnosis remains an unsolved challenge. Here the authors develop ‘Seldegs’, antigens linked to human Fc fragments with high affinity for the neonatal Fc receptor FcRn,
Externí odkaz:
https://doaj.org/article/7077cda82f6d4593beeed48ce19dff2c
Autor:
E. Sally Ward, Raimund J. Ober, Ralph P. Mason, Alan Schroit, Hong Tian, Siva Charan Devanaboyina, David Kim, Ramraj Velmurugan, Dongyoung Kim, Li Li, Srinivas Chiguru, Ran Li
In response to cellular stress, phosphatidylserine is exposed on the outer membrane leaflet of tumor blood vessels and cancer cells, motivating the development of phosphatidylserine-specific therapies. The generation of drug-conjugated phosphatidylse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92085005f8e6d9ef756fbc970e4cdd26
https://doi.org/10.1158/1535-7163.c.6537763
https://doi.org/10.1158/1535-7163.c.6537763
Autor:
E. Sally Ward, Raimund J. Ober, Ralph P. Mason, Alan Schroit, Hong Tian, Siva Charan Devanaboyina, David Kim, Ramraj Velmurugan, Dongyoung Kim, Li Li, Srinivas Chiguru, Ran Li
Document containing supplementary figures; Figure S1. Gel filtration analyses of recombinant Fc fusions; Figure S2. Exposure of PS by tumor endothelial cells; Figure S3. Subcellular trafficking analyses of bivalent and tetravalent Fc-Syt1 fusions; Fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e929a64f1b2ecb0ab1ea61b9ebb23d
https://doi.org/10.1158/1535-7163.22504528.v1
https://doi.org/10.1158/1535-7163.22504528.v1
Autor:
Samuel Hughes, Benjamin Greenberg, Siva Charan Devanaboyina, Raimund J. Ober, E. Sally Ward, Dilip K. Challa, Priyanka Khare, Ramraj Velmurugan
Myelin oligodendrocyte glycoprotein (MOG) is exposed on the outer surface of the myelin sheath, and as such, represents a possible target antigen for antibodies in multiple sclerosis (MS) and other demyelinating diseases. However, despite extensive a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305f3d1cc7ef03223753d19aebe70b68
https://eprints.soton.ac.uk/423685/
https://eprints.soton.ac.uk/423685/
Autor:
Siva Charan Devanaboyina, Srinivas Chiguru, E. Sally Ward, Alan J. Schroit, Li Li, Ran Li, Ralph P. Mason, Hong Tian, Dongyoung Kim, Ramraj Velmurugan, David G. Kim, Raimund J. Ober
In response to cellular stress, phosphatidylserine is exposed on the outer membrane leaflet of tumor blood vessels and cancer cells, motivating the development of phosphatidylserine-specific therapies. The generation of drug-conjugated phosphatidylse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e3904c5d39da0ae8be2ac0cbc83717
https://europepmc.org/articles/PMC5752623/
https://europepmc.org/articles/PMC5752623/
Autor:
Fabio Dall’Antonia, Siva Charan Devanaboyina, Andreas Nandy, S. Hagen, Kerstin Fauland, Rudolph Valenta, Sabine Flicker, Christian Lupinek, Walter Keller, Carolin Cornelius
Publikováno v:
Allergy. 69:1617-1628
Background Group 2 and 3 grass pollen allergens are major allergens with high allergenic activity and exhibit structural similarity with the C-terminal portion of major group 1 allergens. In this study, we aimed to determine the crystal structure of
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
Here we have designed a novel class of engineered antibody-based reagents (‘Seldegs') that induce the selective degradation of antigen-specific antibodies. We demonstrate the rapid and specific clearance of antibodies recognizing the autoantigen, m
Publikováno v:
Molecular immunology. 67(2 Pt)
The MHC class I-related receptor, FcRn, is a multitasking protein that transports its IgG ligand within and across cells of diverse origins. The role of this receptor as a global regulator of IgG homeostasis and transport, combined with knowledge of
Autor:
Srinath Kasturirangan, Lutz Jermutus, Shannon Breen, Raimund J. Ober, Herren Wu, Dongyoung Kim, Sripad Ram, Sandra M Lynch, Alberto Puig-Canto, Li Peng, Siva Charan Devanaboyina, Carl I. Webster, E. Sally Ward, Changshou Gao, Haihong Zhong, Susan B. Fowler
A drawback of targeting soluble antigens such as cytokines or toxins with long-lived antibodies is that such antibodies can prolong the half-life of the target antigen by a "buffering" effect. This has motivated the design of antibodies that bind to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbfcf31ffa609f01c6d41968aced5331
https://eprints.soton.ac.uk/423640/
https://eprints.soton.ac.uk/423640/