Microwave-assisted synthesis, structure, and preliminary biological evaluation of novel 6-methoxy-5,6-dihydro-5-azapurines

Autor: Siutkina, Alena I., Kalinina, Svetlana, Liu, Rongfang, Heitman, Laura H., Junker, Anna, Daniliuc, Constantin Gabriel, Kalinin, Dmitrii V.

Publikováno v: ACS Omega, 8(15), 14097-14112. American Chemical Society (ACS)

We herein disclose the microwave-assisted synthesis of previously unreported 6-methoxy-5,6-dihydro-5-azapurines, whose purine-like scaffold is promising for drug discovery. The method is simple, fast, and relies on easily accessible reagents such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbe864acc9afeabaf9f883b0d927499
https://hdl.handle.net/1887/3618918

Microwave-Assisted Synthesis, Structure, and Preliminary Biological Evaluation of Novel 6-Methoxy-5,6-dihydro-5-azapurines.

Autor: Siutkina AI; Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, 48149 Münster, Germany., Kalinina S; Institute of Food Chemistry, University of Münster, 48149 Münster, Germany., Liu R; Leiden Academic Centre for Drug Research (LACDR), Division of Drug Discovery and Safety, Leiden University, 2333 CC Leiden, The Netherlands., Heitman LH; Leiden Academic Centre for Drug Research (LACDR), Division of Drug Discovery and Safety, Leiden University, 2333 CC Leiden, The Netherlands., Junker A; European Institute for Molecular Imaging (EIMI), University of Münster, 48149 Münster, Germany., Daniliuc CG; Institute for Organic Chemistry, University of Münster, 48149 Münster, Germany., Kalinin DV; Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, 48149 Münster, Germany.

Publikováno v: ACS omega [ACS Omega] 2023 Apr 05; Vol. 8 (15), pp. 14097-14112. Date of Electronic Publication: 2023 Apr 05 (Print Publication: 2023).