Výsledky vyhledávání - "Siu-Tsan Yuen"

Akademický článek

Mutational landscape of normal epithelial cells in Lynch Syndrome patients

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)

It is unclear whether somatic mutation rates are elevated in Lynch Syndrome (LS), which is the most common cause of hereditary colorectal cancer. Here, the authors use whole-genome sequencing and organoid cultures to show that normal tissues in LS pa

Externí odkaz: https://doaj.org/article/9ffe8e161f6f47b6ae292571819e0a78

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Data from Association of Inflammation-Related and microRNA Gene Expression with Cancer-Specific Mortality of Colon Adenocarcinoma

Autor: Curtis C. Harris, Suet Yi Leung, Carlo M. Croce, Jason E. Hawkes, Siu Tsan Yuen, Ewy A. Mathé, Elise D. Bowman, Giang Huong Nguyen, Aaron J. Schetter

Purpose: Inflammatory genes and microRNAs have roles in colon carcinogenesis; therefore, they may provide useful biomarkers for colon cancer. This study examines the potential clinical utility of an inflammatory gene expression signature as a prognos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe36961c93d696955659770480ca27a4
https://doi.org/10.1158/1078-0432.c.6517660

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Data from A Gene Expression Signature of Genetic Instability in Colon Cancer

Autor: Jonathan R. Pollack, Eric Bair, Young H. Kim, Siu Tsan Yuen, Xin Chen, Suet Yi Leung, Craig P. Giacomini

Genetic instability plays a central role in the development and progression of human cancer. Two major classes of genetic instability, microsatellite instability (MSI) and chromosome instability (microsatellite stable; MSS), are best understood in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623436a5e8d0e026d98f364bc3109aef
https://doi.org/10.1158/0008-5472.c.6494664

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Data from Topological and Functional Discovery in a Gene Coexpression Meta-Network of Gastric Cancer

Autor: Patrick Tan, Suet Yi Leung, Hiroyuki Aburatani, David Bowtell, Xin Chen, Alex Boussioutas, Samuel So, Kent-Man Chu, Siu Tsan Yuen, Yujin Hoshida, Dong Li Guo, Amit Aggarwal

Gastric cancer is a leading cause of global cancer mortality, but comparatively little is known about the cellular pathways regulating different aspects of the gastric cancer phenotype. To achieve a better understanding of gastric cancer at the level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a13f4c08bc610f0da098c1a837fc181
https://doi.org/10.1158/0008-5472.c.6494249.v1

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Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles

Publikováno v: Gut, 69(12), 2165-2179. BMJ Publishing Group

ObjectiveSporadic early-onset colorectal cancer (EOCRC) has bad prognosis, yet is poorly represented by cell line models. We examine the key mutational and transcriptomic alterations in an organoid biobank enriched in EOCRCs.DesignWe established pair

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f088e70976d8619feae560c7711a9e
https://doi.org/10.1136/gutjnl-2019-320019

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Escape from cell-cell and cell-matrix adhesion dependence underscores disease progression in gastric cancer organoid models

Autor: Yin Tong, Priscilla S W Cheng, Chung Sze Or, Sarah S K Yue, Hoi Cheong Siu, Siu Lun Ho, Simon Y K Law, Wai Yin Tsui, Dessy Chan, Stephanie Ma, Siu Po Lee, Annie S Y Chan, April S Chan, Shui Wa Yun, Ho Sang Hui, Siu Tsan Yuen, Suet Yi Leung, Helen H N Yan

Publikováno v: Gut. 72(2)

ObjectiveCell-cell (CC) and cell-matrix (CM) adhesions are essential for epithelial cell survival, yet dissociation-induced apoptosis is frequently circumvented in malignant cells.DesignWe explored CC and CM dependence in 58 gastric cancer (GC) organ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2f0a7f7354ec79b1de78ffc132ab71
https://pubmed.ncbi.nlm.nih.gov/35705367

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