A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease.

Autor: Thomas T; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.; Centre for Human Genetics, University of Oxford, Oxford, UK.; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK., Friedrich M; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK., Rich-Griffin C; Centre for Human Genetics, University of Oxford, Oxford, UK., Pohin M; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Agarwal D; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Pakpoor J; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.; Centre for Human Genetics, University of Oxford, Oxford, UK.; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK., Lee C; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Tandon R; University College London Hospitals NHS Foundation Trust, London, UK., Rendek A; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Aschenbrenner D; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK., Jainarayanan A; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Voda A; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Siu JHY; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Sanches-Peres R; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Nee E; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Sathananthan D; University of Adelaide, Adelaide, Australia.; Lyell McEwin Hospital, Adelaide, Australia., Kotliar D; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Todd P; Centre for Human Genetics, University of Oxford, Oxford, UK., Kiourlappou M; Centre for Human Genetics, University of Oxford, Oxford, UK., Gartner L; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK., Ilott N; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Issa F; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Hester J; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Turner J; Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK., Nayar S; Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.; National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre and NIHR Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; Birmingham Tissue Analytics, Institute of Translational Medicine, University of Birmingham, Birmingham, UK., Mackerodt J; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Zhang F; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Center for Health AI, University of Colorado Anschutz, Anschutz, CO, USA., Jonsson A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Brenner M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Raychaudhuri S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Kulicke R; Celsius Therapeutics, Cambridge, MA, USA., Ramsdell D; Celsius Therapeutics, Cambridge, MA, USA., Stransky N; Celsius Therapeutics, Cambridge, MA, USA., Pagliarini R; Celsius Therapeutics, Cambridge, MA, USA., Bielecki P; Celsius Therapeutics, Cambridge, MA, USA., Spies N; Celsius Therapeutics, Cambridge, MA, USA., Marsden B; Centre for Human Genetics, University of Oxford, Oxford, UK., Taylor S; Centre for Human Genetics, University of Oxford, Oxford, UK., Wagner A; Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA, USA.; The Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA., Klenerman P; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK., Walsh A; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK., Coles M; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Jostins-Dean L; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Powrie FM; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Filer A; Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.; National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre and NIHR Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; Birmingham Tissue Analytics, Institute of Translational Medicine, University of Birmingham, Birmingham, UK., Travis S; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. simon.travis@kennedy.ox.ac.uk.; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK. simon.travis@kennedy.ox.ac.uk.; NIHR Oxford Biomedical Research Centre, Oxford, UK. simon.travis@kennedy.ox.ac.uk., Uhlig HH; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK. holm.uhlig@ndm.ox.ac.uk.; NIHR Oxford Biomedical Research Centre, Oxford, UK. holm.uhlig@ndm.ox.ac.uk.; Department of Paediatrics, University of Oxford, Oxford, UK. holm.uhlig@ndm.ox.ac.uk., Dendrou CA; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. calliope.dendrou@kennedy.ox.ac.uk.; Centre for Human Genetics, University of Oxford, Oxford, UK. calliope.dendrou@kennedy.ox.ac.uk.; NIHR Oxford Biomedical Research Centre, Oxford, UK. calliope.dendrou@kennedy.ox.ac.uk., Buckley CD; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. christopher.buckley@kennedy.ox.ac.uk.; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK. christopher.buckley@kennedy.ox.ac.uk.; Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK. christopher.buckley@kennedy.ox.ac.uk.; NIHR Oxford Biomedical Research Centre, Oxford, UK. christopher.buckley@kennedy.ox.ac.uk.

Publikováno v: Nature immunology [Nat Immunol] 2024 Nov; Vol. 25 (11), pp. 2152-2165. Date of Electronic Publication: 2024 Oct 22.

Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood.

Autor: Siu JHY; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK., Pitcher MJ; School of Immunology and Microbial Sciences, King's College London, Guy's Campus, London SE1 9RT, UK., Tull TJ; School of Immunology and Microbial Sciences, King's College London, Guy's Campus, London SE1 9RT, UK., Velounias RL; School of Immunology and Microbial Sciences, King's College London, Guy's Campus, London SE1 9RT, UK., Guesdon W; School of Immunology and Microbial Sciences, King's College London, Guy's Campus, London SE1 9RT, UK., Montorsi L; School of Cancer Sciences, King's College London, Guy's Campus, London, UK.; Cancer Systems Biology Laboratory, Francis Crick Institute, London, UK., Mahbubani KT; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK., Ellis R; NIHR Guy's and St Thomas' Biomedical Research Centre, Guy's and St Thomas NHS Foundation Trust, Guy's Hospital, London SE1 9RT, UK., Dhami P; NIHR Guy's and St Thomas' Biomedical Research Centre, Guy's and St Thomas NHS Foundation Trust, Guy's Hospital, London SE1 9RT, UK., Todd K; NIHR Guy's and St Thomas' Biomedical Research Centre, Guy's and St Thomas NHS Foundation Trust, Guy's Hospital, London SE1 9RT, UK., Kadolsky UD; NIHR Guy's and St Thomas' Biomedical Research Centre, Guy's and St Thomas NHS Foundation Trust, Guy's Hospital, London SE1 9RT, UK., Kleeman M; NIHR Guy's and St Thomas' Biomedical Research Centre, Guy's and St Thomas NHS Foundation Trust, Guy's Hospital, London SE1 9RT, UK., D'Cruz DP; School of Immunology and Microbial Sciences, King's College London, Guy's Campus, London SE1 9RT, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK., Bemark M; Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, SE 405 30 Gothenburg, Sweden.; Department of Clinical Immunology and Transfusion Medicine, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden., Pettigrew GJ; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK., Spencer J; School of Immunology and Microbial Sciences, King's College London, Guy's Campus, London SE1 9RT, UK.

Publikováno v: Science immunology [Sci Immunol] 2022 Mar 18; Vol. 7 (69), pp. eabm9060. Date of Electronic Publication: 2022 Mar 18.

Humoral autoimmunity after solid organ transplantation: Germinal ideas may not be natural.

Autor: Siu JHY; University of Cambridge, School of Clinical Medicine, Cambridge CB2 0QQ, UK., Motallebzadeh R; Research Department of Surgical Biotechnology, Institute of Immunity & Transplantation, and Department of Renal Medicine, University College London, London NW3 2PF, UK., Pettigrew GJ; University of Cambridge, School of Clinical Medicine, Cambridge CB2 0QQ, UK. Electronic address: gjp25@cam.ac.uk.

Publikováno v: Cellular immunology [Cell Immunol] 2020 Aug; Vol. 354, pp. 104131. Date of Electronic Publication: 2020 May 19.

Reduced CD27 ^- IgD ^- B Cells in Blood and Raised CD27 ^- IgD ^- B Cells in Gut-Associated Lymphoid Tissue in Inflammatory Bowel Disease.

Autor: Pararasa C; Peter Gorer Department of Immunobiology, King's College London, Guy's Hospital, London, United Kingdom., Zhang N; Peter Gorer Department of Immunobiology, King's College London, Guy's Hospital, London, United Kingdom.; Obstetrics and Gynecology Hospital, Institutes of Biomedical Sciences (IBS), Fudan University, Shanghai, China., Tull TJ; Peter Gorer Department of Immunobiology, King's College London, Guy's Hospital, London, United Kingdom., Chong MHA; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, United Kingdom., Siu JHY; Department of Surgery, Addenbrookes Hospital, University of Cambridge, Cambridge, United Kingdom., Guesdon W; Peter Gorer Department of Immunobiology, King's College London, Guy's Hospital, London, United Kingdom., Chavele KM; Peter Gorer Department of Immunobiology, King's College London, Guy's Hospital, London, United Kingdom., Sanderson JD; Department of Gastroenterology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom., Langmead L; Department of Gastroenterology, Royal London Hospital, Barts Health, London, United Kingdom., Kok K; Department of Gastroenterology, Royal London Hospital, Barts Health, London, United Kingdom., Spencer J; Peter Gorer Department of Immunobiology, King's College London, Guy's Hospital, London, United Kingdom., Vossenkamper A; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, United Kingdom.

Publikováno v: Frontiers in immunology [Front Immunol] 2019 Mar 05; Vol. 10, pp. 361. Date of Electronic Publication: 2019 Mar 05 (Print Publication: 2019).

T cell Allorecognition Pathways in Solid Organ Transplantation.

Autor: Siu JHY; Department of Surgery, University of Cambridge, Cambridge, United Kingdom., Surendrakumar V; Department of Surgery, University of Cambridge, Cambridge, United Kingdom., Richards JA; Department of Surgery, University of Cambridge, Cambridge, United Kingdom., Pettigrew GJ; Department of Surgery, University of Cambridge, Cambridge, United Kingdom.

Publikováno v: Frontiers in immunology [Front Immunol] 2018 Nov 05; Vol. 9, pp. 2548. Date of Electronic Publication: 2018 Nov 05 (Print Publication: 2018).