Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Siu Hong Chan"'
Autor:
Thiruselvam Viswanathan, Anurag Misra, Siu-Hong Chan, Shan Qi, Nan Dai, Shailee Arya, Luis Martinez-Sobrido, Yogesh K. Gupta
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
The SARS-CoV-2 nsp16/nsp10 enzyme complex methylates the 2′-OH of the first nucleotide of the viral mRNA, converting the Cap-0 to Cap-1, which helps the virus to evade immune surveillance in the host cell. Here, the authors present the crystal stru
Externí odkaz:
https://doaj.org/article/f218a0ba562445fea22bd96245c64491
Autor:
Thiruselvam Viswanathan, Shailee Arya, Siu-Hong Chan, Shan Qi, Nan Dai, Anurag Misra, Jun-Gyu Park, Fatai Oladunni, Dmytro Kovalskyy, Robert A. Hromas, Luis Martinez-Sobrido, Yogesh K. Gupta
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Specific non-structural proteins (nsp) of SARS coronaviruses are involved in methylation of virally encoded mRNAs to mimic cellular mRNAs for protection against host innate immune restriction. Here, the authors present a high resolution structure of
Externí odkaz:
https://doaj.org/article/1a2c5dcfc62842e8b013e549e88fbd22
Autor:
Shan Qi, Javier Mota, Siu-Hong Chan, Johanna Villarreal, Nan Dai, Shailee Arya, Robert A Hromas, Manjeet K Rao, Ivan R Corrêa Jr, Yogesh K Gupta
Publikováno v:
eLife, Vol 11 (2022)
Methyltransferase like-3 (METTL3) and METTL14 complex transfers a methyl group from S-adenosyl-L-methionine to N6 amino group of adenosine bases in RNA (m6A) and DNA (m6dA). Emerging evidence highlights a role of METTL3-METTL14 in the chromatin conte
Externí odkaz:
https://doaj.org/article/f4794168c2784b479a677f7a2e4a2a3c
Autor:
Shan Qi, Anurag Misra, Nan Dai, Yogesh K. Gupta, Shailee Arya, Luis Martinez-Sobrido, Thiruselvam Viswanathan, Siu-Hong Chan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
bioRxiv
article-version (status) pre
article-version (number) 1
bioRxiv
article-version (status) pre
article-version (number) 1
The SARS-CoV-2 nsp16/nsp10 enzyme complex modifies the 2′-OH of the first transcribed nucleotide of the viral mRNA by covalently attaching a methyl group to it. The 2′-O methylation of the first nucleotide converts the status of mRNA cap from Cap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2663932c8d3be16894d12aa53d262b
https://doaj.org/article/f218a0ba562445fea22bd96245c64491
https://doaj.org/article/f218a0ba562445fea22bd96245c64491
Autor:
Myung-Ju Ahn, Marvin Jonne L. Mendoza, Nick Pavlakis, Terufumi Kato, Ross A. Soo, Dong-Wan Kim, Chong Kin Liam, Te-Chun Hsia, Chee Khoon Lee, Thanyanan Reungwetwattana, Sarayut Geater, Oscar Siu Hong Chan, Naiyarat Prasongsook, Benjamin J. Solomon, Thi Thai Hoa Nguyen, Toshiyuki Kozuki, James Chih-Hsin Yang, Yi-Long Wu, Tony Shu Kam Mok, Daniel Shao-Weng Tan, Yasushi Yatabe
Publikováno v:
Clinical lung cancer. 23(8)
Non-small cell lung cancer (NSCLC) is a heterogeneous disease, with many oncogenic driver mutations, including de novo mutations in the Mesenchymal Epithelial Transition (MET) gene (specifically in Exon 14 [ex14]), that lead to tumourigenesis. Acquir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d4a230ae61118c1a1445097b3fb696b
https://pubmed.ncbi.nlm.nih.gov/36151006
https://pubmed.ncbi.nlm.nih.gov/36151006
Autor:
Javier Mota, Shan Qi, Siu-Hong Chan, Johanna Villarreal, Nan Dai, Shailee Arya, Robert A Hromas, Manjeet K Rao, Ivan R Corrêa Jr, Yogesh K Gupta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0af79273bba51048c2ff37f71031e585
https://doi.org/10.7554/elife.67150.sa2
https://doi.org/10.7554/elife.67150.sa2
Autor:
Siu-Hong Chan, Bijoyita Roy
Publikováno v:
RNA Technologies ISBN: 9783031084140
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4918aae2db8626a665e2f9e2b9ce3cf
https://doi.org/10.1007/978-3-031-08415-7_9
https://doi.org/10.1007/978-3-031-08415-7_9
Autor:
Anurag Misra, Nan Dai, Thiruselvam Viswanathan, Shan Qi, Yogesh K. Gupta, Luis Martinez-Sobrido, Siu-Hong Chan, Shailee Arya
The SARS-CoV-2 nsp16/nsp10 enzyme complex modifies the 2’-OH of the first transcribed nucleotide of the viral mRNA by covalently attaching a methyl group to it. The 2’-O methylation of the first nucleotide converts the status of mRNA cap from Cap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78176074992b4c35261eb87e3f40820d
https://doi.org/10.1101/2021.03.12.435174
https://doi.org/10.1101/2021.03.12.435174
Autor:
Shan, Qi, Javier, Mota, Siu-Hong, Chan, Johanna, Villarreal, Nan, Dai, Shailee, Arya, Robert A, Hromas, Manjeet K, Rao, Ivan R, Corrêa, Yogesh K, Gupta
Publikováno v:
eLife. 11
Methyltransferase like-3 (METTL3) and METTL14 complex transfers a methyl group from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b24bd0fec4b09536e633f5ecff7a6f84
https://pubmed.ncbi.nlm.nih.gov/35060905
https://pubmed.ncbi.nlm.nih.gov/35060905
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80967 (2013)
Restriction enzyme (REase) RM.BpuSI can be described as a Type IIS/C/G REase for its cleavage site outside of the recognition sequence (Type IIS), bifunctional polypeptide possessing both methyltransferase (MTase) and endonuclease activities (Type II
Externí odkaz:
https://doaj.org/article/41b818833a534067b4ec76d48a4dc26a