Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Siu Chiu Chan"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The transcription factor hepatocyte nuclear factor 1β (HNF-1β) is essential for normal development of the kidney and other epithelial organs. In the developing mouse kidney, HNF-1β is required for the differentiation and patterning of imm
Externí odkaz:
https://doaj.org/article/417169e99d534528b8335f6d090026f3
Autor:
Scott M. Dehm, Kevin A.T. Silverstein, Tae Hyun Hwang, Lucas J. Brand, Siu Chiu Chan, Yingming Li
Persistent androgen receptor (AR) transcriptional activity underlies resistance to AR-targeted therapy and progression to lethal castration-resistant prostate cancer (CRPC). Recent success in retargeting persistent AR activity with next generation an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b83ac610ae41a74afdb1dcc545e32100
https://doi.org/10.1158/0008-5472.c.6505547
https://doi.org/10.1158/0008-5472.c.6505547
Autor:
Scott M. Dehm, Kevin A.T. Silverstein, Tae Hyun Hwang, Lucas J. Brand, Siu Chiu Chan, Yingming Li
PDF file - 654K, Supplementary Figure 1: Antiandrogens achieve on-target inhibition of full-length AR in 22Rv1 cells Supplementary Figure 2: CWR-R1 cells harboring a 48kb intragenic deletion in AR intron 1 display androgen-independent growth Suppleme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51882417c38c910fc69c3d8a3d528cf6
https://doi.org/10.1158/0008-5472.22400288.v1
https://doi.org/10.1158/0008-5472.22400288.v1
Publikováno v:
J Biol Chem
Hepatocyte nuclear factor-1β (HNF-1β) is a tissue-specific transcription factor that is required for normal kidney development and renal epithelial differentiation. Mutations of HNF-1β produce congenital kidney abnormalities and inherited renal tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f0949096a3aefdf33912c67d2377e64
https://pubmed.ncbi.nlm.nih.gov/33453998
https://pubmed.ncbi.nlm.nih.gov/33453998
Autor:
Chao Xing, Dayeon Lee, Mohammed Kanchwala, Svetlana Avdulov, Peter Igarashi, Shayan Farahani, Micah D. Gearhart, Alan Mickelson, Karam Aboudehen, Vishal Patel, Siu Chiu Chan
Publikováno v:
Journal of Biological Chemistry. 293:9388-9398
Autosomal dominant polycystic kidney disease (ADPKD) is a debilitating disease that is characterized by the accumulation of numerous fluid-filled cysts in the kidney. ADPKD is primarily caused by mutations in two genes, PKD1 and PKD2. Long noncoding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42b86752ef937349305f29485c8ac0e3
https://doi.org/10.1074/jbc.ra118.001723
https://doi.org/10.1074/jbc.ra118.001723
Publikováno v:
Proc Natl Acad Sci U S A
Hepatocyte nuclear factor-1β (HNF-1β) is a tissue-specific transcription factor that is essential for normal kidney development and renal tubular function. Mutations of HNF-1β produce cystic kidney disease, a phenotype associated with deregulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71218060faf5cd4acc4c99bdf06da4c5
https://pubmed.ncbi.nlm.nih.gov/31712448
https://pubmed.ncbi.nlm.nih.gov/31712448
Autor:
Karam Aboudehen, Ying Zhang, Marco Pontoglio, Svetlana Avdulov, Peter Igarashi, Annie Shao, Jeremy Herrera, Siu Chiu Chan
Background Mutation of HNF1B , the gene encoding transcription factor HNF-1 β , is one cause of autosomal dominant tubulointerstitial kidney disease, a syndrome characterized by tubular cysts, renal fibrosis, and progressive decline in renal functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414c0dd784d94912f8d1ffac467669d8
https://europepmc.org/articles/PMC6171276/
https://europepmc.org/articles/PMC6171276/
Autor:
Karam, Aboudehen, Shayan, Farahani, Mohammed, Kanchwala, Siu Chiu, Chan, Svetlana, Avdulov, Alan, Mickelson, Dayeon, Lee, Micah D, Gearhart, Vishal, Patel, Chao, Xing, Peter, Igarashi
Publikováno v:
The Journal of biological chemistry. 293(24)
Autosomal dominant polycystic kidney disease (ADPKD) is a debilitating disease that is characterized by the accumulation of numerous fluid-filled cysts in the kidney. ADPKD is primarily caused by mutations in two genes, PKD1 and PKD2. Long noncoding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23ea875036ac57a5fe2ef7746f70d729
https://pubmed.ncbi.nlm.nih.gov/29716997
https://pubmed.ncbi.nlm.nih.gov/29716997
Autor:
Scott M. Dehm, Luke A. Selth, Michael D. Nyquist, Wayne D. Tilley, Siu Chiu Chan, Ganesh V. Raj, Lu Miao, Yingming Li, James E. Bradner
Publikováno v:
Nucleic Acids Research
Androgen receptor (AR) variants (AR-Vs) expressed in prostate cancer (PCa) lack the AR ligand binding domain (LBD) and function as constitutively active transcription factors. AR-V expression in patient tissues or circulating tumor cells is associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7502b30a45f0abcefa76bafc30400d
http://europepmc.org/articles/PMC4499120
http://europepmc.org/articles/PMC4499120
Autor:
Siu Chiu Chan1, Hajarnis, Sachin S.2, Vrba, Sophia M.1, Patel, Vishal2, Igarashi, Peter1,2 igarashi@umn.edu
Publikováno v:
Journal of Biological Chemistry. 12/18/2020, Vol. 295 Issue 51, p17560-17572. 13p.