Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sittinon, Tang"'
Autor:
Hua Zhang, Ting Chen, Vamsidhar Velcheti, Kwok-Kin Wong, Jared E Lopes, Heather C Losey, Elaine Shum, Han Han, Hai Hu, Yuanwang Pan, Yuan Hao, Hailin Ding, Kristen E Labbe, Kayla Guidry, Fiona Sherman, Ke Geng, Janaye Stephens, Alison Chafitz, Sittinon Tang, Hsin-Yi Huang, Chengwei Peng, Christina Almonte, Raymond J Winquist
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Small cell lung cancer (SCLC) is a deadly disease with a 5-year survival of less than 7%. The addition of immunotherapy to chemotherapy was recently approved as first-line treatment; however, the improved clinical benefit is modest, highli
Externí odkaz:
https://doaj.org/article/5f4845cac4494148a2dafe15454c9d88
Autor:
Kwok-Kin Wong, Sylvie Vincent, Rachael Brake, Victor M. Rivera, Haiquan Chen, Francois Gonzalvez, Sittinon Tang, Eleni Papadopoulos, Cassandra Thakurdin, Val Pyon, Hai Hu, Hailin Ding, Yuanwang Pan, Hua Zhang, Fei Li, Theresa E. Baker, Zhendong Gao, Jiehui Deng, David Peng, Jiansheng Wu, Johara Chouitar, Shougen Cao, Kwan Ho Tang, Chengwei Peng, Shengwu Liu, Michael Fitzgerald, Ting Chen, Shuai Li, Han Han
GSEA analysis of mobocertinib and T-DM1 treated tumors versus mobocertinib-only treated tumors Genes involved in "INTERFERON ALPHA RESPONSE", "INFLAMMATORY RESPONSE", "INTERFERON GAMMA RESPONSE", "IL2 STAT5 SIGNALING", "TNFA SIGNALING VIA NFKB" and "
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc292ba115983e2e9d41bf0078c4067
https://doi.org/10.1158/0008-5472.22490195
https://doi.org/10.1158/0008-5472.22490195
Autor:
Kwok-Kin Wong, Sylvie Vincent, Rachael Brake, Victor M. Rivera, Haiquan Chen, Francois Gonzalvez, Sittinon Tang, Eleni Papadopoulos, Cassandra Thakurdin, Val Pyon, Hai Hu, Hailin Ding, Yuanwang Pan, Hua Zhang, Fei Li, Theresa E. Baker, Zhendong Gao, Jiehui Deng, David Peng, Jiansheng Wu, Johara Chouitar, Shougen Cao, Kwan Ho Tang, Chengwei Peng, Shengwu Liu, Michael Fitzgerald, Ting Chen, Shuai Li, Han Han
No targeted treatments are currently approved for HER2 exon 20 insertion–mutant lung adenocarcinoma patients. Mobocertinib (TAK-788) is a potent irreversible tyrosine kinase inhibitor (TKI) designed to target human epidermal growth factor receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3282ae56d3b65e02abbca4ecf45fe434
https://doi.org/10.1158/0008-5472.c.6533114
https://doi.org/10.1158/0008-5472.c.6533114
Autor:
Kwok-Kin Wong, Sylvie Vincent, Rachael Brake, Victor M. Rivera, Haiquan Chen, Francois Gonzalvez, Sittinon Tang, Eleni Papadopoulos, Cassandra Thakurdin, Val Pyon, Hai Hu, Hailin Ding, Yuanwang Pan, Hua Zhang, Fei Li, Theresa E. Baker, Zhendong Gao, Jiehui Deng, David Peng, Jiansheng Wu, Johara Chouitar, Shougen Cao, Kwan Ho Tang, Chengwei Peng, Shengwu Liu, Michael Fitzgerald, Ting Chen, Shuai Li, Han Han
Figure S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b801af9cd01bb649be8ad1b6d441cd
https://doi.org/10.1158/0008-5472.22490216
https://doi.org/10.1158/0008-5472.22490216
Autor:
Hua Zhang, Christopher S. Nabel, Dezhi Li, Ruth Í. O’Connor, Caroline R. Crosby, Sarah M. Chang, Yuan Hao, Robyn Stanley, Soumyadip Sahu, Daniel S. Levin, Ting Chen, Sittinon Tang, Hsin-Yi Huang, Mary Meynardie, Janaye Stephens, Fiona Sherman, Alison Chafitz, Naoise Costelloe, Daniel A. Rodrigues, Hilda Fogarty, Miranda G. Kiernan, Fiona Cronin, Eleni Papadopoulos, Magdalena Ploszaj, Vajira Weerasekara, Jiehui Deng, Patrick Kiely, Nabeel Bardeesy, Matthew G. Vander Heiden, Triona Ni Chonghaile, Catríona M. Dowling, Kwok-Kin Wong
Publikováno v:
Journal of Thoracic Oncology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f3feaf2b2400c8509da78446b8ec3f5
https://doi.org/10.1016/j.jtho.2023.03.014
https://doi.org/10.1016/j.jtho.2023.03.014
Autor:
Hua Zhang, Haiquan Chen, Sittinon Tang, Shougen Cao, Yuanwang Pan, Victor M. Rivera, Shuai Li, Fei Li, Kwan Ho Tang, Hai Hu, Chengwei Peng, Francois Gonzalvez, Hailin Ding, Jiehui Deng, Johara Chouitar, Han Han, Sylvie Vincent, Theresa E. Baker, Michael Fitzgerald, Val Pyon, Ting Chen, Zhendong Gao, Rachael L. Brake, Eleni Papadopoulos, David H. Peng, Jiansheng Wu, Cassandra Thakurdin, Kwok-Kin Wong, Shengwu Liu
Publikováno v:
Cancer Research. 81:5311-5324
No targeted treatments are currently approved for HER2 exon 20 insertion–mutant lung adenocarcinoma patients. Mobocertinib (TAK-788) is a potent irreversible tyrosine kinase inhibitor (TKI) designed to target human epidermal growth factor receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f7997759bba1b98f3f10b2c5af242a6
https://doi.org/10.1158/0008-5472.can-21-1526
https://doi.org/10.1158/0008-5472.can-21-1526
Autor:
Yuanwang Pan, Yuan Hao, Han Han, Ting Chen, Hailin Ding, Kristen E Labbe, Elaine Shum, Kayla Guidry, Hai Hu, Fiona Sherman, Ke Geng, Janaye Stephens, Alison Chafitz, Sittinon Tang, Hsin-Yi Huang, Chengwei Peng, Christina Almonte, Jared E Lopes, Heather C Losey, Raymond J Winquist, Vamsidhar Velcheti, Hua Zhang, Kwok-Kin Wong
Publikováno v:
Journal for immunotherapy of cancer. 10(9)
BackgroundSmall cell lung cancer (SCLC) is a deadly disease with a 5-year survival of less than 7%. The addition of immunotherapy to chemotherapy was recently approved as first-line treatment; however, the improved clinical benefit is modest, highlig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d066777967055bb157d69269f541db5b
https://pubmed.ncbi.nlm.nih.gov/36472839
https://pubmed.ncbi.nlm.nih.gov/36472839
Autor:
Qingyuan Huang, Fei Li, Hai Hu, Zhaoyuan Fang, Zhendong Gao, Guozhan Xia, Wai-Lung Ng, Alireza Khodadadi-Jamayran, Ting Chen, Jiehui Deng, Hua Zhang, Christina Almonte, Kristen Labbe, Han Han, Ke Geng, Sittinon Tang, Gordon J. Freeman, Yuan Li, Haiquan Chen, Kwok-Kin Wong
Publikováno v:
Science Advances. 8
Tuberous sclerosis complex subunit 1 ( TSC1 ) and 2 ( TSC2 ) are frequently mutated in non–small cell lung cancer (NSCLC), however, their effects on antitumor immunity remained unexplored. A CRISPR screening in murine Kras G12D / Trp53 −/− (KP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3144ebe96fbc510ed58721efd72e32b3
https://doi.org/10.1126/sciadv.abi9533
https://doi.org/10.1126/sciadv.abi9533
Autor:
Qingyuan, Huang, Fei, Li, Hai, Hu, Zhaoyuan, Fang, Zhendong, Gao, Guozhan, Xia, Wai-Lung, Ng, Alireza, Khodadadi-Jamayran, Ting, Chen, Jiehui, Deng, Hua, Zhang, Christina, Almonte, Kristen, Labbe, Han, Han, Ke, Geng, Sittinon, Tang, Gordon J, Freeman, Yuan, Li, Haiquan, Chen, Kwok-Kin, Wong
Publikováno v:
Science advances. 8(5)
Tuberous sclerosis complex subunit 1 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa2b7361d4cb97a0951158043536f9f2
https://pubmed.ncbi.nlm.nih.gov/35119931
https://pubmed.ncbi.nlm.nih.gov/35119931
Autor:
Yuanwang Pan, Han Han, Hai Hu, Hua Wang, Yueqiang Song, Yuan Hao, Xinyuan Tong, Ayushi S. Patel, Selim Misirlioglu, Sittinon Tang, Hsin-Yi Huang, Ke Geng, Ting Chen, Angeliki Karatza, Fiona Sherman, Kristen E. Labbe, Fan Yang, Alison Chafitz, Chengwei Peng, Chenchen Guo, Andre L. Moreira, Vamsidhar Velcheti, Sally C.M. Lau, Pengfei Sui, Haiquan Chen, J. Alan Diehl, Anil K. Rustgi, Adam J. Bass, John T. Poirier, Xiaoyang Zhang, Hongbin Ji, Hua Zhang, Kwok-Kin Wong
Publikováno v:
Cancer Cell. 41:88-105.e8
Lung squamous cell carcinoma (LUSC) represents a major subtype of lung cancer with limited treatment options. KMT2D is one of the most frequently mutated genes in LUSC (20%), and yet its role in LUSC oncogenesis remains unknown. Here, we identify KMT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8823013bbad79cedb7de1458a121de37
https://doi.org/10.1016/j.ccell.2022.11.015
https://doi.org/10.1016/j.ccell.2022.11.015