Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Siti-Faujiah Hendrayani"'
Autor:
Huda H Al-Khalaf, Dilek Colak, Maher Al-Saif, Albandary Al-Bakheet, Siti-Faujiah Hendrayani, Nujoud Al-Yousef, Namik Kaya, Khalid S Khabar, Abdelilah Aboussekhra
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21111 (2011)
BackgroundThe cyclin-D/CDK4,6/p16(INK4a)/pRB/E2F pathway, a key regulator of the critical G1 to S phase transition of the cell cycle, is universally disrupted in human cancer. However, the precise function of the different members of this pathway and
Externí odkaz:
https://doaj.org/article/d7f9ff83f9be405ab2aa0df2055b4300
Publikováno v:
BMC Cancer
Background Active fibroblasts, the predominant and the most active cells of breast cancer stroma, are responsible for tumor growth and spread. However, the molecular mediators and pathways responsible for stromal fibroblast activation, and their para
Publikováno v:
Molecular Carcinogenesis. 51:930-938
The universal cyclin-dependent kinase inhibitor p21(WAF1/Cip1) promotes cell cycle arrest and inhibits apoptosis in response to UV-induced DNA damage. Since the protein kinase ATR plays a major role in the cellular response to these carcinogenic lesi
Publikováno v:
Molecular Cancer Research. 9:311-319
The tumor suppressor p16INK4A, a phosphoprotein that exists in human cells under both phosphorylated and nonphosphorylated forms, plays crucial roles during the cellular response to UV light. However, it is still unclear how this protein is activated
Autor:
Dahish Ajarim, Asma Tulbah, Taher Al-Tweigeri, Said Dermime, Siti-Faujiah Hendrayani, Abdelilah Aboussekhra, Hazem Ghebeh, Ayodele Alaiya, Maha Al-Eid, Nahed M. Hawsawi
Publikováno v:
Cancer Research. 68:2717-2725
It has become clear that the initiation and progression of carcinomas depend not only on alterations in epithelial cells, but also on changes in their microenvironment. To identify these changes, we have undertaken cellular and molecular characteriza
Publikováno v:
Molecular carcinogenesis. 51(12)
The universal cyclin-dependent kinase inhibitor p21(WAF1/Cip1) promotes cell cycle arrest and inhibits apoptosis in response to UV-induced DNA damage. Since the protein kinase ATR plays a major role in the cellular response to these carcinogenic lesi
Autor:
Abdelilah Aboussekhra, Siti-Faujiah Hendrayani, Dilek Colak, Namik Kaya, Nujoud Al-Yousef, Maher Al-Saif, Albandary Al-Bakheet, Khalid S.A. Khabar, Huda H. Al-Khalaf
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 7, p e21111 (2011)
PLoS ONE, Vol 6, Iss 7, p e21111 (2011)
BackgroundThe cyclin-D/CDK4,6/p16(INK4a)/pRB/E2F pathway, a key regulator of the critical G1 to S phase transition of the cell cycle, is universally disrupted in human cancer. However, the precise function of the different members of this pathway and
Autor:
Maha H, Elamin, Zakia, Shinwari, Siti-Faujiah, Hendrayani, Hindi, Al-Hindi, Essam, Al-Shail, Yasser, Khafaga, Amani, Al-Kofide, Abdelilah, Aboussekhra
Publikováno v:
Molecular carcinogenesis. 49(3)
Medulloblastoma is an aggressive primary brain tumor that arises in the cerebellum of children and young adults. The Sonic Hedgehog (Shh) signaling pathway that plays important roles in the pathology of this aggressive disease is a promising therapeu
Autor:
Abdelilah Aboussekhra, Hazem Ghebeh, Cynthia Lehe, Siti-Faujiah Hendrayani, Khaldoon Al-Romaih, Asma Tulbah, Ayodele Alaiya, Monther Al-Alwan, Taher Al-Tweigeri, Pulicat S. Manogaran, Said Dermime, Eman Barhoush
Publikováno v:
Breast Cancer Research : BCR
Introduction B7-H1 (PD-L1, CD274) is a T cell inhibitory molecule expressed in many types of cancer, leading to immune escape of tumor cells. Indeed, in previous reports we have shown an association of B7-H1 expression with high-risk breast cancer pa