Towards the in silico reconstruction of protein interaction networks : identification of DNA- and RNA-protein interfaces, and construction of a database of multiple interactions of proteins

Autor: Corsi, Flavia

Publikováno v: Structural Biology [q-bio.BM]. Sorbonne Université, 2019. English. ⟨NNT : 2019SORUS452⟩

This thesis focuses on the characterization and prediction of DNA- and RNA-binding sites on protein structures, with some comparisons with protein-protein ones. We compiled and manually curated a non-redundant and representative set of 187 high resol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::698f903ba8bc69ff2fb81c9dfe7462cb
https://tel.archives-ouvertes.fr/tel-02862115

Investigation of enzymes from the respiratory chain by using electrochemical and spectroscopic techniques

Autor: Sabuncu, Sinan

Le présent travail porte sur l’étude de deux protéines de la famille des oxydases à hème-fer par des techniques de spectroscopie et d’électrochimie. Le premier chapitre décrit l’étude du cytochrome bo3 oxydase issue d’E. coli. Nous no

Externí odkaz: http://www.theses.fr/2017STRAF017/document

Arabidopsis thaliana GH3.5 acyl acid amido synthetase mediates metabolic crosstalk in auxin and salicylic acid homeostasis

Autor: Romain Marcellin, Loren Ramirez, Corey S. Westfall, Evelyn Schraft, Sophie Alvarez, Joseph M. Jez, Chloe Zubieta, Ashley M. Sherp

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (48), pp.13917-13922. ⟨10.1073/pnas.1612635113⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2016, 113 (48), pp.13917-13922. ⟨10.1073/pnas.1612635113⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2016, 113 (48), pp.13917-13922
Proceedings of the National Academy of Sciences of the United States of America 48 (113), 13917-13922. (2016)

International audience; In Arabidopsis thaliana, the acyl acid amido synthetase Gretchen Hagen 3.5 (AtGH3.5) conjugates both indole-3-acetic acid (IAA) and salicylic acid (SA) to modulate auxin and pathogen response pathways. To understand the molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee047706f135fb99c3aa0c6010c4a0e
https://hal.science/hal-01515228/file/2016_Westfall_PNAS_1.pdf

Cartography of protein-protein interfaces and research of drugable cavities

Autor: Da Silva, Franck

Publikováno v: Chemo-informatique. Université de Strasbourg, 2016. Français. ⟨NNT : 2016STRAF034⟩

Protein-protein interfaces are involved in many physiological mechanisms of living cells. Their characterization at the molecular level is therefore crucial in drug discovery.We propose here new methods for the analysis protein-protein interfaces of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d720f3f2054257620c677b3762fcce82
https://tel.archives-ouvertes.fr/tel-01508554/document

Characterization of natural product biological imprints for computer-aided drug design applications

Autor: Sturm, Noé

La comparaison de site peut-elle vérifier l’hypothèse: «Les origines biosynthétiques des produits naturels leurs confèrent des activités biologiques»? Pour répondre à cette question, nous avons développé un outil modélisant les proprié

Externí odkaz: http://www.theses.fr/2015STRAF059/document