Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Sitaram Gayatri"'
Autor:
Guozhen Gao, Simone Hausmann, Natasha M. Flores, Ana Morales Benitez, Jianjun Shen, Xiaojie Yang, Maria D. Person, Sitaram Gayatri, Donghang Cheng, Yue Lu, Bin Liu, Pawel K. Mazur, Mark T. Bedford
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Protein arginine methylation can contribute to tumor progression. Here the authors show that protein arginine methyltransferase, CARM1, methylates transcription factor NFIB to promote the growth of small cell lung cancers.
Externí odkaz:
https://doaj.org/article/5a5c0f39343444caa6a8bb5f6e7611a0
Autor:
Maxim I. Maron, Stephanie M. Lehman, Sitaram Gayatri, Joseph D. DeAngelo, Subray Hegde, Benjamin M. Lorton, Yan Sun, Dina L. Bai, Simone Sidoli, Varun Gupta, Matthew R. Marunde, James R. Bone, Zu-Wen Sun, Mark T. Bedford, Jeffrey Shabanowitz, Hongshan Chen, Donald F. Hunt, David Shechter
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102971- (2021)
Summary: Protein arginine methyltransferases (PRMTs) catalyze the post-translational monomethylation (Rme1), asymmetric (Rme2a), or symmetric (Rme2s) dimethylation of arginine. To determine the cellular consequences of type I (Rme2a) and II (Rme2s) P
Externí odkaz:
https://doaj.org/article/c804eaefab6848b4b721da294a0ebcd5
Autor:
Nicolas Veland, Swanand Hardikar, Yi Zhong, Sitaram Gayatri, Jiameng Dan, Brian D. Strahl, Scott B. Rothbart, Mark T. Bedford, Taiping Chen
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3390-3397 (2017)
Summary: DNA methylation plays crucial roles in chromatin structure and gene expression. Aberrant DNA methylation patterns, including global hypomethylation and regional hypermethylation, are associated with cancer and implicated in oncogenic events.
Externí odkaz:
https://doaj.org/article/7f414f8837684284866b48335ef2ff51
Autor:
Srilatha Nalluri, Sampa Ghoshal-Gupta, Ammar Kutiyanawalla, Sitaram Gayatri, Byung Rho Lee, Shahanawaz Jiwani, Amyn M Rojiani, Mumtaz V Rojiani
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137673 (2015)
Tissue inhibitors of metalloproteinases (TIMPs) are multifaceted molecules that exhibit properties beyond their classical proteinase inhibitory function. Although TIMP-1 is a known inhibitor of apoptosis in mammalian cells, the mechanisms by which it
Externí odkaz:
https://doaj.org/article/ad8bde583cfd4bc8bc3ae65c81c37157
Autor:
Shaiju K Vareed, Vadiraja B Bhat, Christopher Thompson, Vihas T Vasu, Damian Fermin, Hyungwon Choi, Chad J Creighton, Sitaram Gayatri, Ling Lan, Nagireddy Putluri, Gagan Singh Thangjam, Punit Kaur, Mohsen Shabahang, Judith G Giri, Alexey I Nesvizhskii, Alexander A A Asea, Anil G Cashikar, Arundhati Rao, James McLoughlin, Arun Sreekumar
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17177 (2011)
Pancreatic Adenocarcinoma (PDAC), the fourth highest cause of cancer related deaths in the United States, has the most aggressive presentation resulting in a very short median survival time for the affected patients. Early detection of PDAC is confou
Externí odkaz:
https://doaj.org/article/5c58f13c4990418e949ac96c90b1b6c2
Autor:
Emre Sevgen, Joshua Moller, Adrian Lange, John Parker, Sean Quigley, Jeff Mayer, Poonam Srivastava, Sitaram Gayatri, David Hosfield, Maria Korshunova, Micha Livne, Michelle Gill, Rama Ranganathan, Anthony B. Costa, Andrew L. Ferguson
The data-driven design of protein sequences with desired function is challenged by the absence of good theoretical models for the sequence-function mapping and the vast size of protein sequence space. Deep generative models have demonstrated success
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64c920f3acf3e7849a02e4f8b84b588e
https://doi.org/10.1101/2023.01.23.525232
https://doi.org/10.1101/2023.01.23.525232
Autor:
David R. Amici, Daniel J. Ansel, Kyle A. Metz, Roger S. Smith, Claire M. Phoumyvong, Sitaram Gayatri, Tomasz Chamera, Stacey L. Edwards, Brendan P. O’Hara, Shashank Srivastava, Sonia Brockway, Seesha R. Takagishi, Byoung-Kyu Cho, Young Ah Goo, Neil L. Kelleher, Issam Ben-Sahra, Daniel R. Foltz, Jian Li, Marc L. Mendillo
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(27)
All cells contain specialized signaling pathways that enable adaptation to specific molecular stressors. Yet, whether these pathways are centrally regulated in complex physiological stress states remains unclear. Using genome-scale fitness screening
Autor:
Roger S. Smith, Seesha R. Takagishi, David R. Amici, Kyle Metz, Sitaram Gayatri, Milad J. Alasady, Yaqi Wu, Sonia Brockway, Stephanie L. Taiberg, Natalia Khalatyan, Mikko Taipale, Sandro Santagata, Luke Whitesell, Susan Lindquist, Jeffrey N. Savas, Marc L. Mendillo
Publikováno v:
Science advances. 8(11)
Heat shock factor 1 (HSF1) is well known for its role in the heat shock response (HSR), where it drives a transcriptional program comprising heat shock protein (HSP) genes, and in tumorigenesis, where it drives a program comprising HSPs and many nonc
Autor:
James R. Bone, Jeffrey Shabanowitz, Dina L. Bai, Matthew R. Marunde, Emmanuel S. Burgos, Zu-Wen Sun, Varun Gupta, Maxim I. Maron, David Shechter, Sitaram Gayatri, Simone Sidoli, Stephanie M. Lehman, Mark T. Bedford, Edward Nieves, Donald F. Hunt, Hongshan Chen
Arginine methylation is essential for both cellular viability and development and is also dysregulated in cancer. PRMTs catalyze the post translational monomethylation (Rme1/MMA, catalyzed by Type I-III), asymmetric (Rme2a/ADMA, Type I enzymes)-, or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84a25ee4fee537251be8b5c8680c19f6
https://doi.org/10.1101/2020.06.23.167601
https://doi.org/10.1101/2020.06.23.167601
Autor:
Taiping Chen, Swanand Hardikar, Yi Zhong, Jiameng Dan, Nicolas Veland, Brian D. Strahl, Mark T. Bedford, Sitaram Gayatri, Scott B. Rothbart
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3390-3397 (2017)
Summary: DNA methylation plays crucial roles in chromatin structure and gene expression. Aberrant DNA methylation patterns, including global hypomethylation and regional hypermethylation, are associated with cancer and implicated in oncogenic events.